{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:23:40Z","timestamp":1777893820983,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Adipose tissue-derived stem cells (ADSCs) have two essential characteristics with regard to regenerative medicine: the convenient and efficient generation of large numbers of multipotent cells and in vitro proliferation without a loss of stemness. The implementation of clinical trials has prompted widespread concern regarding safety issues and has shifted research toward the therapeutic efficacy of stem cells in dealing with neural degeneration in cases such as stroke, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, cavernous nerve injury, and traumatic brain injury. Most existing studies have reported that cell therapies may be able to replenish lost cells and promote neuronal regeneration, protect neuronal survival, and play a role in overcoming permanent paralysis and loss of sensation and the recovery of neurological function. The mechanisms involved in determining therapeutic capacity remain largely unknown; however, this concept can still be classified in a methodical manner by citing current evidence. Possible mechanisms include the following: 1) the promotion of angiogenesis, 2) the induction of neuronal differentiation and neurogenesis, 3) reductions in reactive gliosis, 4) the inhibition of apoptosis, 5) the expression of neurotrophic factors, 6) immunomodulatory function, and 7) facilitating neuronal integration. In this study, several human clinical trials using ADSCs for neuronal disorders were investigated. It is suggested that ADSCs are one of the choices among various stem cells for translating into clinical application in the near future.<\/jats:p>","DOI":"10.3727\/096368915x686940","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T19:53:48Z","timestamp":1428522828000},"page":"487-492","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Adipose Tissue-Derived Stem Cells in Neural Regenerative Medicine"],"prefix":"10.1177","volume":"24","author":[{"given":"Da-Chuan","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, China Medical University Beigan Hospital, Yunlin, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Min","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, China Medical University Beigan Hospital, Yunlin, Taiwan"},{"name":"Department of Medical Education and Research, China Medical University-An-Nan Hospital, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horng-Jyh","family":"Harn","sequence":"additional","affiliation":[{"name":"Department of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Pathology, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzyy-Wen","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Shui","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation, China Medical University Beigang Hospital, Yunlin, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zung-Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery, China Medical University Beigan Hospital, Yunlin, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinn-Zong","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Immunology, China Medical University, Taichung, Taiwan"},{"name":"Department of Neurosurgery, China Medical University Beigan Hospital, Yunlin, Taiwan"},{"name":"Department of Neurosurgery, Tainan Municipal An-Nan Hospital-China Medical University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01875.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.08.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070648"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X678409"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X678292"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2012.00382.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds524"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2741\/2097"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.02.035"},{"issue":"11","key":"e_1_3_2_11_2","first-page":"998","article-title":"[The effects of adipose-derived stem cell transplantation on the expression of IL-10 and TNF-alpha after cerebral ischaemia in rats].","volume":"25","author":"Du H. W.","year":"2009","unstructured":"DuH. W. LiuN. WangJ. H. ZhangY. X. ChenR. H. XiaoY. C. [The effects of adipose-derived stem cell transplantation on the expression of IL-10 and TNF-alpha after cerebral ischaemia in rats]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25(11): 998\u20131001; 2009.","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-010-0113-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.152"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.2.137"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4161\/org.24279"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31824ecae6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-411512-5.00012-9"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.02.057"},{"issue":"86","key":"e_1_3_2_19_2","first-page":"37","article-title":"Adipose tissue-derived stem cells in stroke treatment: From bench to bedside.","volume":"16","author":"Gutierrez-Fernandez M.","year":"2013","unstructured":"Gutierrez-FernandezM. Rodriguez-FrutosB. Otero-OrtegaL. Ramos-CejudoJ. FuentesB. Diez-TejedorE. Adipose tissue-derived stem cells in stroke treatment: From bench to bedside. Discov. Med. 16(86): 37\u201343; 2013.","journal-title":"Discov. Med."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2010.549122"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059438"},{"key":"e_1_3_2_22_2","first-page":"RRN1183","article-title":"Transplantation of patient-derived adipose stem cells in YAC128 Huntington's disease transgenic mice.","volume":"2","author":"Im W.","year":"2010","unstructured":"ImW. LeeS. T. ParkJ. E. OhH. J. ShimJ. LimJ. ChuK. KimM. Transplantation of patient-derived adipose stem cells in YAC128 Huntington's disease transgenic mice. PLoS Curr. 2: RRN1183; 2010.","journal-title":"PLoS Curr."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1341"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23746"},{"issue":"64","key":"e_1_3_2_25_2","first-page":"1152","article-title":"[Pathogenic mechanisms of neurodegenerative diseases: Amyotrophic lateral sclerosis].","volume":"2","author":"Kato A. C.","year":"2006","unstructured":"KatoA. C. VingerhoetsF. J. MagistrisM. R. KuntzerT. BurkhardP. R. [Pathogenic mechanisms of neurodegenerative diseases: Amyotrophic lateral sclerosis]. Rev. Med. Suisse 2(64): 1152\u20131154, 1156\u20131157; 2006.","journal-title":"Rev. Med. Suisse"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368913X673450"},{"issue":"9","key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"e45757","DOI":"10.1371\/journal.pone.0045757","article-title":"The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice.","volume":"7","author":"Kim S.","year":"2012","unstructured":"KimS. ChangK. A. KimJ. ParkH. G. RaJ. C. KimH. S. SuhY. H. The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice. PLoS One 7(9): e45757; 2012.","journal-title":"PLoS One"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.06.029"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07761"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X627516"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.12.076"},{"issue":"1","key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.3727\/096368913X672181","article-title":"Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice.","volume":"22","author":"Ma T.","year":"2013","unstructured":"MaT. GongK. AoQ. YanY. SongB. HuangH. ZhangX. GongY. Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice. Cell Transplant. 22(Suppl 1): S113\u2013S126; 2013.","journal-title":"Cell Transplant."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.05.034"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24432"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-13-21"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1056784"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368908786576516"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-102070"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-181"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0466"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X661382"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2221"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-40"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00469-2"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-012-9637-4"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2011-0593"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000254463.24655.14"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142616.07367.66"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720508786898451"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2425-13.2014"},{"issue":"1","key":"e_1_3_2_51_2","first-page":"S5","article-title":"A brief history of Alzheimer's disease gene discovery.","volume":"33","author":"Tanzi R. E.","year":"2013","unstructured":"TanziR. E. A brief history of Alzheimer's disease gene discovery. J. Alzheimers Dis. 33(Suppl 1): S5\u2013S13; 2013.","journal-title":"J. Alzheimers Dis."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/01376517-200804000-00002"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)53012-8"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.08.001"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12636"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.02.035"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720211794520215"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22567"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2007.0181"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02128.x"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.01.007"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-07-0589"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368915X686940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3727\/096368915X686940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3727\/096368915X686940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:39:48Z","timestamp":1777390788000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3727\/096368915X686940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.3727\/096368915X686940"],"URL":"https:\/\/doi.org\/10.3727\/096368915x686940","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}