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Mesenchymal stem cells (MSCs) are currently being investigated as a treatment for several such retinal diseases based on their neuroprotective and angiogenic potentials. In this study, we evaluated the role of systemically injected human placental amniotic membrane-derived MSCs (AMSCs) on pathological neovascularization of proliferative retinopathy. We determined that AMSCs secrete higher levels of transforming growth factor-\u03b2 (TGF-\u03b21) than other MSCs, and the secreted TGF-\u03b21 directly suppresses the proliferation of endothelial cells under pathological conditions in vitro. Moreover, in a mouse model of oxygen-induced retinopathy, intraperitoneally injected AMSCs migrated into the retina and suppressed excessive neovascularization of the vasculature via expression of TGF-\u03b21, and the antineovascular effect of AMSCs was blocked by treatment with TGF-\u03b21 siRNA. These findings are the first to demonstrate that TGF-\u03b21 secreted from AMSCs is one of the key factors to suppress retinal neovascularization in proliferative retinopathy and further elucidate the therapeutic function of AMSCs for the treatment of retinal neovascular diseases.<\/jats:p>","DOI":"10.3727\/096368915x688263","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:33:24Z","timestamp":1454546004000},"page":"1145-1157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Retinal Angiogenesis Effects of TGF-\u03b21 and Paracrine Factors Secreted from Human Placental Stem Cells in Response to a Pathological Environment"],"prefix":"10.1177","volume":"25","author":[{"given":"Kyung-Sul","family":"Kim","sequence":"first","affiliation":[{"name":"College of Life Science, Department of Biotechnology, CHA University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Min","family":"Park","sequence":"additional","affiliation":[{"name":"College of Life Science, Department of Biotechnology, CHA University, Seoul, Korea"},{"name":"General Research Institute, Gangnam CHA General Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeho","family":"Kong","sequence":"additional","affiliation":[{"name":"College of Life Science, Department of Biotechnology, CHA University, Seoul, Korea"},{"name":"General Research Institute, Gangnam CHA General Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Life Science, Department of Biotechnology, CHA University, Seoul, Korea"},{"name":"General Research Institute, Gangnam CHA General Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hun","family":"Bae","sequence":"additional","affiliation":[{"name":"College of Life Science, Department of Biotechnology, CHA University, Seoul, Korea"},{"name":"General Research Institute, Gangnam CHA General Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Wool","family":"Kim","sequence":"additional","affiliation":[{"name":"General Research Institute, Gangnam CHA General Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisook","family":"Moon","sequence":"additional","affiliation":[{"name":"College of Life Science, Department of Biotechnology, CHA University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,6,1]]},"reference":[{"issue":"6","key":"bibr1-096368915X688263","first-page":"S689","volume":"7","author":"Abdulrazzak H.","year":"2010","journal-title":"J. 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