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Over this period, the paws were sensitive to both stimuli at 1-2 weeks and returned toward normal at 3 weeks. Immunohistology showed no evidence of axonal regeneration into the spinal cord in a control group of rats with avulsion only, implying that adjacent dorsal roots and their corresponding dermatomes were involved in the recovery. In a further group of rats, a mixture of bulbar olfactory ensheathing cells and olfactory nerve fibroblasts were transplanted into the gap between the avulsed roots and the spinal cord at the time of avulsion. These rats showed no evidence of either loss of sensation or exaggerated responses to stimuli at any of the time points from 1 to 3 weeks. Immunohistology showed that the transplanted cells formed a complete bridge, and the central branches of the dorsal root fibers had regenerated into the dorsal horn of the spinal cord. These regenerating axons, including Tuj1 and CGRP immunoreactive fibers, were ensheathed by the olfactory ensheathing cells. This confirms our previous demonstration of central regeneration by these transplants and suggests that such transplants may provide a useful means to prevent the development of abnormal sensations such as allodynia after spinal root lesions.<\/jats:p>","DOI":"10.3727\/096368917x695353","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T07:18:00Z","timestamp":1490339880000},"page":"913-924","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Transplantation of Cultured Olfactory Bulb Cells Prevents Abnormal Sensory Responses during Recovery from Dorsal Root Avulsion in the Rat"],"prefix":"10.1177","volume":"26","author":[{"given":"Andrew","family":"Collins","sequence":"first","affiliation":[{"name":"Spinal Repair Unit, Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, Queen Square, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Li","sequence":"additional","affiliation":[{"name":"Spinal Repair Unit, Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, Queen Square, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Mcmahon","sequence":"additional","affiliation":[{"name":"The Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London Guy's Campus, London Bridge, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Raisman","sequence":"additional","affiliation":[{"name":"Spinal Repair Unit, Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, Queen Square, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Spinal Repair Unit, Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, Queen Square, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20832"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2008-00438"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2011.01176.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/863062"},{"issue":"3","key":"e_1_3_2_6_2","first-page":"483","article-title":"Rehabilitation of brachial plexus injuries in adults and children.","volume":"48","author":"Smania S.","year":"2012","unstructured":"SmaniaS. 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