{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:07:34Z","timestamp":1790813254290,"version":"4.1.0"},"reference-count":61,"publisher":"Xia & He Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gene expr"],"published-print":{"date-parts":[[2017,2,10]]},"abstract":"<jats:p>Hepatoblastoma is the most common pediatric liver malignancy, typically striking children within the first 3 years of their young lives. While advances in chemotherapy and newer surgical techniques have improved survival in patients with localized disease, unfortunately, for the 25% of patients with metastasis, the overall survival remains poor. These tumors, which are thought to arise from hepatic progenitors or hepatoblasts, hence the name hepatoblastoma, can be categorized by histological subtyping based on their level of cell differentiation. Genomic and histological analysis of human tumor samples has shown exon-3 deletions or missense mutations in gene coding for \u03b2-catenin, a downstream effector of the Wnt signaling pathway, in up to 90% of hepatoblastoma cases. The current article will review key aberrations in molecular pathways that are implicated in various subtypes of hepatoblastoma with an emphasis on Wnt signaling. It will also discuss cooperation among components of pathways such as \u03b2-catenin and Yes-associated protein in cancer development. Understanding the complex network of molecular signaling in oncogenesis will undoubtedly aid in the discovery of new therapeutics to help combat hepatoblastoma.<\/jats:p>","DOI":"10.3727\/105221616x693639","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T16:43:10Z","timestamp":1479314590000},"page":"141-154","source":"Crossref","is-referenced-by-count":98,"title":["Novel Advances in Understanding of Molecular Pathogenesis of Hepatoblastoma: A Wnt\/\u03b2-Catenin Perspective"],"prefix":"10.14218","volume":"17","author":[{"given":"Danielle","family":"Bell","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Pittsburgh, School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarangarajan","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satdarshan P.","family":"Monga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5334","reference":[{"issue":"3","key":"b1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/jhep.2003.50375","article-title":"Epidemiology of primary hepatic malignancies in U.S. children","volume":"38","year":"2003","journal-title":"Hepatology"},{"issue":"9","key":"b2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/aje\/kwj104","article-title":"Maternal and infant birth characteristics and hepatoblastoma","volume":"163","year":"2006","journal-title":"Am J Epidemiol."},{"key":"b3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejca.2015.09.023","article-title":"The Children\u2019s Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model","volume":"52","year":"2016","journal-title":"Eur J Cancer"},{"issue":"14","key":"b4","first-page":"3032","article-title":"Increased risk of hepatoblastoma among immature children with a lower birth weight","volume":"58","year":"1998","journal-title":"Cancer Res."},{"issue":"9","key":"b5","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/sj.bjc.6604335","article-title":"Perinatal risk factors for hepatoblastoma","volume":"98","year":"2008","journal-title":"Br J Cancer"},{"issue":"4","key":"b6","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/cncr.10282","article-title":"Surgical view of the treatment of patients with hepatoblastoma: Results from the first prospective trial of the International Society of Pediatric Oncology Liver Tumor Study Group","volume":"94","year":"2002","journal-title":"Cancer"},{"issue":"1","key":"b7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MOP.0000000000000046","article-title":"Hepatoblastoma state of the art: Pathology, genetics, risk stratification, and chemotherapy","volume":"26","year":"2014","journal-title":"Curr Opin Pediatr."},{"issue":"9","key":"b8","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.jpedsurg.2004.05.020","article-title":"Hepatoblastoma\u2014Evolution of management and outcome and significance of histology of the resected tumor. 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