{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:12:51Z","timestamp":1783710771669,"version":"3.55.0"},"reference-count":99,"publisher":"Xia & He Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["gene expr"],"published-print":{"date-parts":[[2017,7,7]]},"abstract":"<jats:p>\n                    Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome with neuroendocrine tumorigenesis of the parathyroid glands, pituitary gland, and pancreatic islet cells. The\n                    <jats:italic>MEN1<\/jats:italic>\n                    gene codes for the canonical tumor suppressor protein, menin. Its protein structure has recently been crystallized, and it has been investigated in a multitude of other tissues. In this review, we summarize recent advancements in understanding the structure of the menin protein and its function as a scaffold protein in histone modification and epigenetic gene regulation. Furthermore, we explore its role in hepatobiliary autoimmune diseases, cancers, and metabolic diseases. In particular, we discuss how menin expression and function are regulated by extracellular signaling factors and nuclear receptor activation in various hepatic cell types. How the many signaling pathways and tissue types affect menin\u2019s diverse functions is not fully understood. We show that small-molecule inhibitors affecting menin function can shed light on menin\u2019s broad role in pathophysiology and elucidate distinct menin-dependent processes. This review reveals menin\u2019s often dichotomous function through analysis of its role in multiple disease processes and could potentially lead to novel small-molecule therapies in the treatment of cholangiocarcinoma or biliary autoimmune diseases.\n                  <\/jats:p>","DOI":"10.3727\/105221617x695744","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T05:18:38Z","timestamp":1494307118000},"page":"251-263","source":"Crossref","is-referenced-by-count":13,"title":["A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology"],"prefix":"10.14218","volume":"17","author":[{"given":"Laurent","family":"Ehrlich","sequence":"first","affiliation":[{"name":"Department of Medicine, Texas A&M Health Science Center, College of Medicine, Temple, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanyin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Lairmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Alpini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5334","reference":[{"issue":"5311","key":"b1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia-type 1","volume":"276","year":"1997","journal-title":"Science"},{"issue":"4","key":"b2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.soc.2015.06.008","article-title":"Multiple endocrine neoplasia: Genetics and clinical management","volume":"24","year":"2015","journal-title":"Surg Oncol Clin N Am."},{"issue":"2","key":"b3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5493\/wjem.v5.i2.124","article-title":"Genetic test in multiple endocrine neoplasia type 1 syndrome: An evolving story","volume":"5","year":"2015","journal-title":"World J Exp Med."},{"issue":"2","key":"b4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2265.2006.02563.x","article-title":"Multiple endocrine neoplasia type 1 (MEN 1) is associated with an increased prevalence of diabetes mellitus and impaired fasting glucose","volume":"65","year":"2006","journal-title":"Clin Endocrinol. (Oxf)"},{"issue":"1","key":"b5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/humu.20605","article-title":"Multiple endocrine neoplasia type 1 (MEN1): Analysis of 1336 mutations reported in the first decade following identification of the gene","volume":"29","year":"2008","journal-title":"Hum Mutat."},{"issue":"2","key":"b6","doi-asserted-by":"crossref","first-page":"E282","DOI":"10.1210\/jc.2011-0241","article-title":"Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: Restoration of expression and activity by CHIP siRNA","volume":"97","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"8","key":"b7","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tibs.2013.05.005","article-title":"Menin: A scaffold protein that controls gene expression and cell signaling","volume":"38","year":"2013","journal-title":"Trends Biochem 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Dis."},{"issue":"2","key":"b48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbrc.2015.02.074","article-title":"1,25-(OH)(2)-vitamin D(3) prevents activation of hepatic stellate cells in vitro and ameliorates inflammatory liver damage but not fibrosis in the Abcb4(-\/-) model","volume":"459","year":"2015","journal-title":"Biochem Biophys Res Commun."},{"issue":"5","key":"b49","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.2337\/db15-1331","article-title":"Inhibition of TGF-beta signaling promotes human pancreatic beta-cell replication","volume":"65","year":"2016","journal-title":"Diabetes"},{"issue":"5","key":"b50","first-page":"531","article-title":"Roles of Smad3 and Smad7 in rat pancreatic stellate cells activated by transforming growth factor-beta 1","volume":"9","year":"2010","journal-title":"Hepatobiliary Pancreat Dis Int."},{"key":"b51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1476-4598-10-67","article-title":"Differential 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