{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:58:46Z","timestamp":1777510726410,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Graft-versus-host-disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is associated with high morbimortality and decreased patients' physical capacity. We evaluated the effects of an 11-week moderate-intensity exercise (treadmill) training program performed after allo-HSCT in a murine acute (aGVHD) and chronic GVHD model (cGVHD). Female mice (aged 8\u201312 weeks) were randomly assigned to the exercise or the control group. They completed a maximal treadmill test before allo-HSCT (with donor bone marrow cells and splenocytes) and after the 11-week period, during which we evaluated clinical severity scores and survival (Kaplan\u2013Meier method). Before allo-HSCT and at days +21, +52 and +83 (upon sacrifice), we collected blood samples for immune cell reconstitution and cytokine analysis. The main results were that (i) in aGVHD, exercise improved maximal physical capacity over the 11-week period compared with pre-allo-HSCT conditions ( p &lt; 0.001 for the between-group comparison) and benefited total clinical score evolution ( p = 0.05 for the group\u00d7time interaction effect), without altering immune reconstitution; (ii) in cGVHD, exercise training resulted in a lesser deterioration of physical capacity after 11 weeks ( p = 0.023). Our results highlight the potential beneficial effects of exercise as coadjuvant intervention against GVHD, especially in the acute form of the disease.<\/jats:p>","DOI":"10.3727\/096368912x658746","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T10:48:16Z","timestamp":1365504496000},"page":"2409-2420","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of Exercise Interventions in Graft-Versus-Host Disease Models"],"prefix":"10.1177","volume":"22","author":[{"given":"Carmen","family":"Fiuza-Luces","sequence":"first","affiliation":[{"name":"Universidad Europea and Instituto de Investigaci\u00f3n (i+12), Madrid, Spain"}]},{"given":"\u00c1frica","family":"Gonz\u00e1lez-Murillo","sequence":"additional","affiliation":[{"name":"Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}]},{"given":"Luisa","family":"Soares-Miranda","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal"}]},{"given":"Jes\u00fas Mart\u00ednez","family":"Palacio","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT), Madrid, Spain"}]},{"given":"Isabel","family":"Colmenero","sequence":"additional","affiliation":[{"name":"Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}]},{"given":"Fernando","family":"Casco","sequence":"additional","affiliation":[{"name":"Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}]},{"given":"Gustavo","family":"Mel\u00e9n","sequence":"additional","affiliation":[{"name":"Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}]},{"given":"Mar\u00eda","family":"Mor\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratorio de Enfermedades Raras: Mitocondriales y Neuromusculares, Instituto de Investigaci\u00f3n Hospital Universitario, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), U723, Valencia, Spain"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[{"name":"Universidad Europea and Instituto de Investigaci\u00f3n (i+12), Madrid, Spain"}]},{"given":"Manuel","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}]}],"member":"179","published-online":{"date-parts":[[2013,12,1]]},"reference":[{"key":"bibr1-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01795-8"},{"key":"bibr2-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0945"},{"key":"bibr3-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181c4dac1"},{"key":"bibr4-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3239"},{"key":"bibr5-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4285"},{"key":"bibr6-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3230.bloodjournal8883230"},{"key":"bibr7-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60237-3"},{"key":"bibr8-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.09.004"},{"key":"bibr9-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.08.073"},{"key":"bibr10-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.491"},{"key":"bibr11-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.10.21"},{"key":"bibr12-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3180616b27"},{"key":"bibr13-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200301000-00002"},{"key":"bibr14-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e3281eacef1"},{"key":"bibr15-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2006.00668.x"},{"key":"bibr16-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.144709"},{"key":"bibr17-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000243644.20993.54"},{"key":"bibr18-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.3.373"},{"key":"bibr19-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200112000-00012"},{"key":"bibr20-096368912X658746","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/427863"},{"key":"bibr21-096368912X658746","first-page":"221","volume":"43","author":"Lucia A.","year":"2009","journal-title":"J. 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