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Fibroblasts maintain the structural integrity of connective tissue by continuously secreting growth factors and extracellular matrix precursors, which are essential for endothelial cell (EC) adhesion and spreading, thus playing a crucial role in angiogenesis. We hypothesized that FBs immobilized in alginate gels grafted with the RGD peptidic sequence could influence the recruitment of ECs to improve vascularization. In this work, the modulation of immobilized human FBs within the 3D synthetic extracellular matrix was assessed. Experiments using cocultures of ECs and FBs in indirect contact as well as angiogenic assays were performed to assess the influence of FBs immobilized in RGD\u2013alginate in ECs' viability, stabilization, sprouting, and assembly into capillary-like structures. This study demonstrates the ability of FBs immobilized within RGD\u2013alginate microspheres to modulate and support capillary-like structures' assembly. These findings indicate that the microenvironment created by these stromal cells in the scaffold modulates capillary morphogenesis, thus stimulating angiogenesis in situ and can potentially be used in regenerative medicine in clinical scenarios where vascularization is essential.<\/jats:p>","DOI":"10.3727\/096368913x670183","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T19:28:04Z","timestamp":1406921284000},"page":"945-957","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Neonatal Human Dermal Fibroblasts Immobilized in RGD\u2013Alginate Induce Angiogenesis"],"prefix":"10.1177","volume":"23","author":[{"given":"Susana G.","family":"Guerreiro","sequence":"first","affiliation":[{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Porto, Portugal"},{"name":"Universidade do Porto, Faculdade de Medicina (FMUP), Departamento de 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