{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:57:13Z","timestamp":1770677833234,"version":"3.49.0"},"reference-count":447,"publisher":"Open Exploration Publishing","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Explor Dig Dis"],"accepted":{"date-parts":[[2026,1,18]]},"abstract":"<jats:p xml:lang=\"en\">Digestive diseases comprise a diverse range of illnesses, which are prevalent worldwide and represent an important health issue. This is particularly relevant for the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) due to its close association with the obesity pandemic, contributing to the escalation of MASLD as the most common form of chronic liver disease, and the main cause of liver cancer. Not only does MASLD reflect the deterioration of liver health, but it also has far-reaching consequences for the development of extrahepatic digestive diseases. Along with the progression of liver and digestive diseases to liver, colorectal and pancreatic cancer, the onset of inflammation in diseases of the digestive tract, drug-induced liver injury, and cholestasis, drives and contributes to the rise of these diseases in the future, which merit the attention of clinical and translational research to increase our understanding of the pathogenic mechanisms underlying these disorders in order to improve the diagnosis, management, and treatment. With this goal in mind, the current collaborative review gathers experts in a wide range of liver and digestive diseases to provide an up-to-date overview of the mechanisms of disease and identify novel strategies for the improvement of these important health issues.<\/jats:p>","DOI":"10.37349\/edd.2026.1005110","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:49:23Z","timestamp":1770616163000},"update-policy":"https:\/\/doi.org\/10.37349\/open_exploration_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding liver and digestive diseases: a paved road to improve diagnosis, management, and treatment"],"prefix":"10.37349","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-4115","authenticated-orcid":false,"given":"Ina","family":"Bergheim","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-4526","authenticated-orcid":false,"given":"Jean Francois","family":"Cadranel","sequence":"additional","affiliation":[{"name":"Department of Liver and Digestive Diseases, Groupe Hospitalier Public du Sud de l\u2019Oise, 60100 Creil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4102-8934","authenticated-orcid":false,"given":"Jianguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Qidong Liver Cancer Institute, Qidong 226200, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3167-5073","authenticated-orcid":false,"given":"Wenxing","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-7144","authenticated-orcid":false,"given":"Robert","family":"Eferl","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, Medical University of Vienna, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-6102","authenticated-orcid":false,"given":"Carmen","family":"Garcia-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Medicine, Institute of Biomedical Research of Barcelona (IIBB), CSIC, 08036 Barcelona, Spain; 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