{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:00:40Z","timestamp":1784786440739,"version":"3.55.0"},"reference-count":65,"publisher":"Open Exploration Publishing","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Explor Target Antitumor Ther"],"accepted":{"date-parts":[[2026,5,25]]},"abstract":"<jats:p xml:lang=\"en\">Aim: This study aims to investigate the expression and function of antisense long non-coding RNA (lncRNA) STEAP3-AS1 in breast cancer (BC). Additionally, it explores STEAP3\u2019s regulatory relationship with STEAP3-AS1 and potential signaling pathways to provide a theoretical foundation for identifying novel therapeutic targets. Methods: Database prediction and collection of tissue samples were employed alongside a cell proliferation assay and Transwell migration and invasion assay to examine STEAP3-AS1 expression levels in BC tissues and cell lines, as well as its impact on cellular functions. Statistical analyses were performed, including two-tailed Student\u2019s t-test, Mann-Whitney U test and analysis of variance (ANOVA). Results: Both database and 9 paired clinical tissue sample results demonstrate that STEAP3-AS1 expression was significantly downregulated in BC compared with normal breast tissues (P &lt; 0.05). Compared with the estrogen receptor\/progesterone receptor (ERPR)-negative (\u2013)\/human epidermal growth factor receptor-2 (Her2)-positive (+) subtype, the ERPR(+)\/Her2(\u2212) and ERPR(\u2212)\/Her2(\u2212) subtypes exhibited a significantly lower expression level of STEAP3-AS1 (P &lt; 0.05). Overexpression of STEAP3-AS1 markedly suppressed the proliferation, migration, and invasion capabilities of MDA-MB-231 and MCF-7 cells compared with negative controls (P &lt; 0.05). Furthermore, STEAP3-AS1 exhibited a positive synergistic effect with its sense strand STEAP3, inhibiting BC cell migration and invasion. Conclusions: This study is the first to demonstrate the tumor-suppressive role of STEAP3-AS1 in BC. These findings provide novel insights into the mechanisms underlying BC progression and offer critical theoretical support for the development of new therapeutic strategies.<\/jats:p>","DOI":"10.37349\/etat.2026.1002380","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:02:14Z","timestamp":1784782934000},"update-policy":"https:\/\/doi.org\/10.37349\/open_exploration_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic study of antisense long non-coding RNA STEAP3-AS1 in breast cancer"],"prefix":"10.37349","volume":"7","author":[{"given":"Jinquan","family":"Sun","sequence":"first","affiliation":[{"name":"Graduate School of Qinghai University, Qinghai University, Xining 810016, Qinghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayong","family":"Cui","sequence":"additional","affiliation":[{"name":"Graduate School of Qinghai University, Qinghai University, Xining 810016, Qinghai, 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