{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:55:20Z","timestamp":1773269720721,"version":"3.50.1"},"reference-count":0,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Combined positron-emission tomography and computed tomography (PET-CT) reduces futile thoracotomy (FT) rates in patients with non-small-cell lung cancer (NSCLC). We sought to identify preoperative risk factors for FT in patients staged with PET-CT. Methods: We retrospectively reviewed all patients referred to the BC Cancer Agency during 2009\u20132010 who underwent PET-CT and thoracotomy for NSCLC. Patients with clinical N2 disease were excluded. An FT was defined as any of a benign lesion; an exploratory thoracotomy; pathologic N2 or N3, stage IIIB or IV, or inoperable T3 or T4 disease; and recurrence or death within 1 year of surgery. Results: Of the 108 patients who met the inclusion criteria, FT occurred in 27. The main reason for FT was recurrence within 1 year (14 patients) and pathologic N2 disease (10 patients). On multivariate analysis, an Eastern Cooperative Oncology Group performance status greater than 1, a PET-CT positive N1 status, a primary tumour larger than 3 cm, and a period of more than 16 weeks from PET-CT to surgery were associated with FT. N2 disease that had been negative on PET-CT occurred in 21% of patients with a PET-CT positive N1 status and in 20% of patients with tumours larger than 3 cm and non-biopsy mediastinal staging only. The combination of PET-CT positive N1 status and a primary larger than 3 cm had 85% specificity, and the presence of either risk factor had 100% sensitivity, for FT attributable to N2 disease. Conclusions: To reduce FT attributable to N2 disease, tissue biopsy for mediastinal staging should be considered for patients with PET-CT positive N1 status and with tumours larger than 3 cm even with a PET-CT negative mediastinum.<\/jats:p>","DOI":"10.3747\/co.21.2125","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T19:59:28Z","timestamp":1418241568000},"page":"768-774","source":"Crossref","is-referenced-by-count":10,"title":["Using pet-ct to Reduce Futile Thoracotomy Rates in Non-Small-Cell Lung Cancer: A Population-Based Review"],"prefix":"10.3390","volume":"21","author":[{"given":"M.","family":"Smoragiewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Laskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ramsden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Shaipanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,12,1]]},"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/21\/6\/2125\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T07:59:57Z","timestamp":1613721597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/21\/6\/2125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,12]]}},"alternative-id":["co.21.2125"],"URL":"https:\/\/doi.org\/10.3747\/co.21.2125","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,1]]}}}