{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:22:14Z","timestamp":1791037334591,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec>\n                    <jats:title>\u2666 Background<\/jats:title>\n                    <jats:p>Inflammation and oxidative stress (OS) are cardiovascular risk factors in patients with chronic kidney disease. N-acetylcysteine (NAC) is a thiol-containing antioxidant with anti-inflammatory properties and has been shown to reduce the number of cardiovascular events in hemodialysis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666 Methods<\/jats:title>\n                    <jats:p>The current study aimed to determine the effect of oral NAC (2 \u00d7 600 mg\/daily) on plasma levels of inflammatory and OS markers in peritoneal dialysis (PD) patients. We performed a placebo-controlled study over 8 weeks in 30 patients (40% males, age 52 \u00b1 13 years) on regular PD. Before the study was started, the patients were divided into 2 groups of 15 patients matched for age and gender. 22 patients completed the study (12 on NAC, 10 on placebo). Proinflammatory cytokines [high-sensitivity C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-alpha, and pentraxin 3] and markers of OS (pentosidine, advanced oxidation protein products, homocysteine, glutathione, asymmetric dimethylarginine, and free sulfhydryls) were measured before and after treatment with NAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666 Results<\/jats:title>\n                    <jats:p>Treatment with NAC for 8 weeks increased mean baseline plasma NAC levels from 2.6 to 24.8 \u03bcmol\/L ( p = 0.007). This intervention, which caused no side effects, significantly diminished IL-6 levels, from 9.4 (4.5 \u2013 31) to 7.6 (4.9 \u2013 13.5) pg\/mL ( p = 0.006), whereas no such changes were observed in the placebo group. NAC treatment did not significantly affect the other inflammatory and OS markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666 Conclusions<\/jats:title>\n                    <jats:p>Short-term oral NAC treatment resulted in reduction of circulating IL-6, suggesting that such treatment could be a useful strategy in blunting the inflammatory response in PD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2009.00073","type":"journal-article","created":{"date-parts":[[2010,2,26]],"date-time":"2010-02-26T20:54:41Z","timestamp":1267217681000},"page":"336-342","source":"Crossref","is-referenced-by-count":89,"title":["Effect of Oral N-Acetylcysteine Treatment on Plasma Inflammatory and Oxidative Stress Markers in Peritoneal Dialysis Patients: A Placebo-Controlled Study"],"prefix":"10.1177","volume":"30","author":[{"given":"Marcelo M.","family":"Nascimento","sequence":"first","affiliation":[{"name":"Faculdade Evang\u00e9lica de Medicina do Paran\u00e1\u2013Brasil, Curitiba, Brazil"},{"name":"Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed E.","family":"Suliman","sequence":"additional","affiliation":[{"name":"Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"},{"name":"King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica de Medicina do Paran\u00e1\u2013Brasil, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Chinaglia","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica de Medicina do Paran\u00e1\u2013Brasil, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Marchioro","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica de Medicina do Paran\u00e1\u2013Brasil, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley Y.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel C.","family":"Riella","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica de Medicina do Paran\u00e1\u2013Brasil, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Anderstam","sequence":"additional","affiliation":[{"name":"Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital, Stockholm, 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