{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:35:25Z","timestamp":1790728525506,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are few reports on the role of peritoneal dialysis in critically ill patients requiring continuous renal replacement therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with acute kidney injury and multi-organ involvement were randomly allotted to continuous venovenous hemodiafiltration(CVVHDF, group A) or to continuous peritoneal dialysis (CPD, group B). Cause and severity of renal failure were assessed at the time of initiating dialysis. Primary outcome was the composite correction of uremia, acidosis, fluid overload, and hyperkalemia. Secondary outcomes were improvement of sensorium and hemodynamic instability, survival, and cost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Groups A and B comprised 25 patients each with mean ages of 45.32 \u00b1 17.53 and 48.44 \u00b1 17.64 respectively. They received 21.68 \u00b1 13.46 hours and 66.02 \u00b1 69.77 hours of dialysis respectively ( p = 0.01). Composite correction was achieved in 12 patients of group A (48%) and in 14 patients of group B (56%). Urea and creatinine clearances were significantly higher in group A (21.72 \u00b1 10.41 mL\/min and 9.36 \u00b1 4.93 mL\/min respectively vs. 22.13 \u00b1 9.61 mL\/min and 10.5 \u00b1 6.07 mL\/min, p &lt; 0.001). Acidosis was present in 21 patients of group A (84%) and in 16 of group B (64%); correction was better in group B ( p &lt; 0.001). Correction of fluid overload was faster and the amount of ultrafiltrate was significantly higher in group A (20.31 \u00b1 21.86 L vs. 5.31 \u00b1 5.75 L, p &lt; 0.001). No significant differences were seen in correction of hyperkalemia, altered sensorium, or hemodynamic disturbance. Mortality was 84% in group A and 72% in group B. Factors that influenced outcome were the APACHE (Acute Physiology and Chronic Health Evaluation) II score ( p = 0.02) and need for ventilatory support ( p &lt; 0.01). Cost of disposables was higher in group A than in group B [INR7184 \u00b1 1436 vs. INR3009 \u00b1 1643, p &lt; 0.001 (US$1 = INR47)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on this pilot study, CPD may be a cost-conscious alternative to CVVHDF; differences in metabolic and clinical outcomes are minimal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2009.00231","type":"journal-article","created":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T16:09:31Z","timestamp":1298995771000},"page":"422-429","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":102,"title":["Comparing Continuous Venovenous Hemodiafiltration and Peritoneal Dialysis in Critically Ill Patients with Acute Kidney Injury: A Pilot Study"],"prefix":"10.1177","volume":"31","author":[{"given":"Jacob","family":"George","sequence":"first","affiliation":[{"name":"Department of Nephrology, Medical College Hospital, Thiruvananthapuram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical College Hospital, Thiruvananthapuram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical College Hospital, Thiruvananthapuram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical College Hospital, Thiruvananthapuram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreepa","family":"Gopi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical College Hospital, Thiruvananthapuram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramdas","family":"Pisharody","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical College Hospital, Thiruvananthapuram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,7,1]]},"reference":[{"key":"bibr1-pdi.2009.00231","doi-asserted-by":"publisher","DOI":"10.3109\/08860229309069409"},{"key":"bibr2-pdi.2009.00231","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020074"},{"key":"bibr3-pdi.2009.00231","doi-asserted-by":"publisher","DOI":"10.1159\/000046671"},{"key":"bibr4-pdi.2009.00231","first-page":"1118","volume":"1","author":"Cameron 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