{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:16:36Z","timestamp":1777889796218,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>\u2666Background<\/jats:title>\n                    <jats:p>The leptin\/adiponectin (L\/A) ratio has been suggested to be an atherosclerotic index for diabetic patients and a useful marker of insulin resistance in patients with and without diabetes. Even though end-stage renal disease (ESRD) patients on peritoneal dialysis (PD) are well characterized by abnormal adipocytokine metabolism, the significance of alterations in the L\/A ratio is largely unexplored in these patients. In this prospective study, we investigated the associations of leptin, adiponectin, and the L\/A ratio with clinical outcomes in nondiabetic PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666Methods<\/jats:title>\n                    <jats:p>The study included 131 stable nondiabetic ESRD patients who had been on PD for more than 3 months. Serum leptin and adiponectin levels were determined at baseline. Mortality was evaluated over a 5-year follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666Results<\/jats:title>\n                    <jats:p>During the follow-up period, 22 patients died (16.8%), including 10 (45.5%) as a result of cardiovascular disease. The L\/A ratio showed a significant positive correlation with body mass index [BMI ( r = 0.47, p &lt; 0.001)], high-sensitivity C-reactive protein ( r = 0.32, p &lt; 0.001), and triglycerides ( r = 0.43, p &lt; 0.001). In addition, we observed significant inverse correlations between the L\/A ratio and percentage lean body mass ( r = \u20130.30, p = 0.001) and high-density lipoprotein cholesterol ( r = \u20130.31, p = 0.001). In contrast to individual leptin and adiponectin levels, the L\/A ratio was found to be independently associated with an increased mortality risk (relative risk: 1.15; 95% confidence interval: 1.05 to 1.27; p = 0.003) even after adjustments for age and BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666Conclusions<\/jats:title>\n                    <jats:p>The L\/A ratio might be better related to patient outcomes than adipocytokines are individually in nondiabetic patients undergoing PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2011.00066","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T20:18:44Z","timestamp":1343852324000},"page":"67-74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Leptin\/Adiponectin Ratio is an Independent Predictor of Mortality in Nondiabetic Peritoneal Dialysis Patients"],"prefix":"10.1177","volume":"33","author":[{"given":"Jung Tak","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Hyun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jwa-Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Jung","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Eun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hyeok","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Suk","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Severance Biomedical Science Institute, Yonsei University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"bibr1-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000232875.27846.7e"},{"key":"bibr2-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00353-6"},{"key":"bibr3-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1177\/089686089801800603"},{"key":"bibr4-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002611"},{"key":"bibr5-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.02.088"},{"key":"bibr6-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.27.9935"},{"key":"bibr7-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.14.1730"},{"key":"bibr8-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12255-6"},{"key":"bibr9-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.485540"},{"key":"bibr10-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.10.2488"},{"key":"bibr11-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.5414\/CNP72087"},{"key":"bibr12-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.191"},{"key":"bibr13-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02207.x"},{"key":"bibr14-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/19891"},{"key":"bibr15-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.03.006"},{"key":"bibr16-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-199207000-00004"},{"key":"bibr17-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V291430"},{"key":"bibr18-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V471475"},{"key":"bibr19-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1159\/000221147"},{"key":"bibr20-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V131134"},{"key":"bibr21-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006040331"},{"key":"bibr22-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1177\/089686089801800204"},{"key":"bibr23-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624777"},{"key":"bibr24-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1177\/089686080702702s51"},{"key":"bibr25-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.042"},{"key":"bibr26-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1177\/089686080502500406"},{"key":"bibr27-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2004.09.034"},{"key":"bibr28-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1177\/089686080302300112"},{"key":"bibr29-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1171303"},{"key":"bibr30-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2009.00228"},{"key":"bibr31-pdi.2011.00066","doi-asserted-by":"publisher","DOI":"10.1373\/49.4.650"}],"container-title":["Peritoneal 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