{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:10:44Z","timestamp":1790359844868,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is limited available evidence regarding the role of monitoring serum gentamicin concentrations in peritoneal dialysis (PD) patients receiving this antimicrobial agent in gram-negative PD-associated peritonitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data collected in all patients receiving PD at a single center who experienced a gram-negative peritonitis episode between 1 January 2005 and 31 December 2011, we investigated the relationship between measured serum gentamicin levels on day 2 following initial empiric antibiotic therapy and subsequent clinical outcomes of confirmed gram-negative peritonitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum gentamicin levels were performed on day 2 in 51 (77%) of 66 first gram-negative peritonitis episodes. Average serum gentamicin levels on day 2 were 1.83 \u00b1 0.84 mg\/L with levels exceeding 2 mg\/L in 22 (43%) cases. The overall cure rate was 64%. No cases of ototoxicity were observed. Day-2 gentamicin levels were not significantly different between patients who did and did not have a complication or cure. Using multivariable logistic regression analysis, failure to cure peritonitis was not associated with either day-2 gentamicin level (adjusted odds ratio (OR) 0.96, 95% confidence interval (CI) 0.25 \u2013 3.73) or continuation of gentamicin therapy beyond day 2 (OR 0.28, 0.02 \u2013 3.56). The only exception was polymicrobial peritonitis, where day-2 gentamicin levels were significantly higher in episodes that were cured (2.06 \u00b1 0.41 vs 1.29 \u00b1 0.71, p = 0.01). In 17 (26%) patients receiving extended gentamicin therapy, day-5 gentamicin levels were not significantly related to peritonitis cure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Day-2 gentamicin levels did not predict gentamicin-related harm or efficacy during short-course gentamicin therapy for gram-negative PD-related peritonitis, except in cases of polymicrobial peritonitis, where higher levels were associated with cure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2012.00318","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T22:17:03Z","timestamp":1388701023000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Monitoring Gentamicin Levels in Patients with Gram-Negative Peritoneal Dialysis-Associated Peritonitis"],"prefix":"10.1177","volume":"34","author":[{"given":"Wen","family":"Tang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Peking University Third Hospital, Beijing, China"},{"name":"Department of Nephrology, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeoungjee","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel M.","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil V.","family":"Badve","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"bibr1-pdi.2012.00318","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00131"},{"key":"bibr2-pdi.2012.00318","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.06.032"},{"key":"bibr3-pdi.2012.00318","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01390.x"},{"key":"bibr4-pdi.2012.00318","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.149"},{"key":"bibr5-pdi.2012.00318","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00010109"},{"key":"bibr6-pdi.2012.00318","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00049"},{"key":"bibr7-pdi.2012.00318","doi-asserted-by":"publisher","DOI":"10.1177\/089686080502500203"},{"key":"bibr8-pdi.2012.00318","doi-asserted-by":"publisher","DOI":"10.1177\/089686080302300610"},{"key":"bibr9-pdi.2012.00318","first-page":"597","volume":"39","author":"Begg 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