{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:32:12Z","timestamp":1783463532938,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>\u2666 Background<\/jats:title>\n                    <jats:p>Peritoneal dialysis (PD) patients develop progressive and cumulative peritoneal injury with longer time spent on PD. The present study aimed to a) describe the trend of peritoneal injury biomarkers, matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1), in incident PD patients, b) to explore the capacity of dialysate MMP-2 to predict peritoneal solute transport rate (PSTR) and peritonitis, and c) to evaluate the influence of neutral pH, low glucose degradation product (GDP) PD solution on these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666 Methods<\/jats:title>\n                    <jats:p>The study included 178 participants from the balANZ trial who had at least 1 stored dialysate sample. Changes in PSTR and peritonitis were primary outcome measures, and the utility of MMP-2 in predicting these outcomes was analyzed using multilevel linear regression and multilevel Poisson regression, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666Results<\/jats:title>\n                    <jats:p>Significant linear increases in dialysate MMP-2 and TIMP-1 concentrations were observed ( p &lt; 0.001), but neither was affected by the type of PD solutions received (MMP-2: p = 0.07; TIMP-1: p = 0.63). An increase in PSTR from baseline was associated with higher levels of MMP-2 ( p = 0.02), and the use of standard solutions over longer PD duration ( p = 0.001). The risk of peritonitis was independently predicted by higher dialysate MMP-2 levels (incidence rate ratio [IRR] per ng\/mL 1.01, 95% confidence interval [CI] 1.005 \u2013 1.02, p = 0.002) and use of standard solutions (Biocompatible solution: IRR 0.45, 95% CI 0.24 \u2013 0.85, p = 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666 Conclusion<\/jats:title>\n                    <jats:p>Dialysate MMP-2 and TIMP-1 concentrations increased with longer PD duration. Higher MMP-2 levels were associated with faster PSTR and future peritonitis risk. Administration of biocompatible solutions exerted no significant effect on dialysate levels of MMP-2 or TIMP-1, but did counteract the increase in PSTR and the risk of peritonitis associated with the use of standard PD solutions. This is the first longitudinal study to examine the clinical utility of MMP-2 as a predictor of patient-level outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2013.00274","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:28:11Z","timestamp":1412728091000},"page":"16-25","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Higher Dialysate Matrix Metalloproteinase-2 Levels are Associated with Peritoneal Membrane Dysfunction"],"prefix":"10.1177","volume":"36","author":[{"given":"Yeoungjee","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Renal Medicine, Princess Alexandra Hospital, Brisbane, Australia"},{"name":"School of medicine, University of Queensland, Brisbane, Australia"},{"name":"Translational Research Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Princess Alexandra Hospital, Brisbane, Australia"},{"name":"School of medicine, University of Queensland, Brisbane, Australia"},{"name":"Translational Research Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Vesey","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Princess Alexandra Hospital, Brisbane, Australia"},{"name":"School of medicine, University of Queensland, Brisbane, Australia"},{"name":"Translational Research Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel M.","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Princess Alexandra Hospital, Brisbane, Australia"},{"name":"School of medicine, University of Queensland, Brisbane, Australia"},{"name":"Translational Research Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M.","family":"Pascoe","sequence":"additional","affiliation":[{"name":"School of medicine, University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Clarke","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Topley","sequence":"additional","affiliation":[{"name":"Institute of Translation, Innovation, Methodology and Engagement, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"bibr1-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.4.962"},{"key":"bibr2-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1177\/089686089701700401"},{"key":"bibr3-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005050566"},{"key":"bibr4-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V971285"},{"key":"bibr5-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.5.1242"},{"key":"bibr6-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V132470"},{"key":"bibr7-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.16"},{"key":"bibr8-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01260209"},{"key":"bibr9-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl566"},{"key":"bibr10-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh262"},{"key":"bibr11-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1177\/089686080002000507"},{"key":"bibr12-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq593"},{"key":"bibr13-pdi.2013.00274","first-page":"6","volume":"27","author":"Ertilav M.","year":"2011","journal-title":"Adv Perit Dial"},{"key":"bibr14-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-004-0310-2"},{"key":"bibr15-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011121201"},{"key":"bibr16-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-11-25"},{"key":"bibr17-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs314"},{"key":"bibr18-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00052"},{"key":"bibr19-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.11.010"},{"key":"bibr20-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001920"},{"key":"bibr21-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.01063"},{"key":"bibr22-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00234"},{"key":"bibr23-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200010150-00002"},{"key":"bibr24-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.5772\/24227"},{"key":"bibr25-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/484167"},{"key":"bibr26-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1159\/000045882"},{"key":"bibr27-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013030314"},{"key":"bibr28-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp670"},{"key":"bibr29-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp767"},{"key":"bibr30-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.022"},{"key":"bibr31-pdi.2013.00274","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-8"}],"container-title":["Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3747\/pdi.2013.00274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3747\/pdi.2013.00274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3747\/pdi.2013.00274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:21:44Z","timestamp":1777612904000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3747\/pdi.2013.00274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.3747\/pdi.2013.00274"],"URL":"https:\/\/doi.org\/10.3747\/pdi.2013.00274","relation":{},"ISSN":["0896-8608","1718-4304"],"issn-type":[{"value":"0896-8608","type":"print"},{"value":"1718-4304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}