{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T18:28:46Z","timestamp":1786472926485,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic exposure to conventional peritoneal dialysis (PD) solutions has been related to peritoneal function alterations in PD patients, and associated with mesothelial cell loss, submesothelial fibrosis, vasculopathy, and angiogenesis. In vitro and ex vivo analyses, as well as studies with animal models, have demonstrated that biocompatible PD solutions attenuate these morphological alterations. Our aim was to confirm the morphological benefits of biocompatible solutions in PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed biopsies from 23 patients treated with biocompatible solutions (study group, SG), and compared them with a control group ( n = 23) treated with conventional solutions (CG), matched for time on PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 56.5% of SG patients showed total or partial preservation of mesothelial cells monolayer, in contrast with 26.1% of patients in CG ( p = 0.036). Peritoneal fibrosis was not significantly less frequent in SG patients (47.8% SG vs 69.6% CG; p = 0.13). In patients without previous peritonitis, a significantly lower prevalence of fibrosis was present in SG patients (41.7% SG vs 77.8% CG; p = 0.04). Hyalinizing vasculopathy (HV) was significantly lower in SG (4.3% SG vs 30.4% CG; p = 0.02). Cytokeratin-positive fibroblast-like cells were detected in 10 patients (22%), but the prevalence was not significantly lower in SG. In the univariate regression analysis, the use of biocompatible solutions was associated with mesothelial monolayer integrity ( p = 0.04) and an absence of vasculopathy ( p = 0.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study demonstrates in vivo in human biopsies that biocompatible solutions are better tolerated by the peritoneum in the medium and long term than conventional solutions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2014.00038","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T23:22:40Z","timestamp":1445037760000},"page":"129-134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Biocompatible Dialysis Solutions Preserve Peritoneal Mesothelial Cell and Vessel Wall Integrity. A Case-Control Study on Human Biopsies"],"prefix":"10.1177","volume":"36","author":[{"given":"Gloria","family":"del Peso","sequence":"first","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Instituto de Investigaci\u00f3n (IdiPAZ), Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Jim\u00e9nez-Heffernan","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Instituto de Investigaci\u00f3n Sanitaria (IIS-IP), Hospital Universitario La Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Selgas","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Instituto de Investigaci\u00f3n (IdiPAZ), Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Rem\u00f3n","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda Hospital Puerto Real, C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ossorio","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Instituto de Investigaci\u00f3n (IdiPAZ), Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fern\u00e1ndez-Perp\u00e9n","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Instituto de Investigaci\u00f3n Sanitaria (IIS-IP), Hospital Universitario La Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"S\u00e1nchez-Tomero","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Instituto de Investigaci\u00f3n Sanitaria (IIS-IP), Hospital Universitario La Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cirugeda","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Hospital Infanta Sof\u00eda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Instituto de Investigaci\u00f3n (IdiPAZ), Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Instituto de Investigaci\u00f3n (IdiPAZ), Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"L\u00f3pez-Cabrera","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Auxiliadora","family":"Bajo","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Instituto de Investigaci\u00f3n (IdiPAZ), Hospital Universitario La Paz, Madrid, 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