{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:16:51Z","timestamp":1777889811184,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>\u2666 Background<\/jats:title>\n                    <jats:p>Preservation of the peritoneum is required for long-term peritoneal dialysis (PD). We investigated the effect of multiple peritonitis episodes on peritoneal transport.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666 Methods<\/jats:title>\n                    <jats:p>Prospectively collected data from 479 incident PD patients treated between 1990 and 2010 were analyzed, using strict inclusion criteria: follow-up of at least 3 years with the availability of a Standard Peritoneal Permeability Analysis (SPA) in the first year after start of PD and within the third year of PD, without peritonitis preceding the first SPA. For the purpose of the study, we only included patients who remained peritonitis-free ( n = 28) or who experienced 3 or more peritonitis episodes ( n = 16).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666Results<\/jats:title>\n                    <jats:p>At baseline the groups were similar with regard to small solute and fluid transport. However, the frequent peritonitis group had lower peritoneal protein clearances compared to the no peritonitis group, resulting in lower dialysate concentrations of proteins: albumin 196.5 mg\/L vs 372.5 mg\/L, IgG 36.4 mg\/L vs 65.0 mg\/L, and \u03b1\u20132-macroglobulin (A2M) 1.9 mg\/L vs 3.6 mg\/L, p &lt;0.01. No differences in serum concentrations were present. A comparison between the transport slopes over time in both groups showed a positive time trend of mass transfer area coefficient (MTAC) creatinine ( p = 0.03) and glucose absorption ( p = 0.09) and a negative trend of transcapillary ultrafiltration ( p = 0.06), when compared to the no peritonitis group. Frequent peritonitis did not affect free water transport.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u2666 Conclusions<\/jats:title>\n                    <jats:p>Slow initial peritoneal transport rates of serum proteins result in lower dialysate concentrations, and likely a lower opsonic activity, which is a risk factor for peritonitis. Patients with frequent peritonitis show an increase in small solute transport and a concomitant decrease of ultrafiltration. In long-term peritonitis-free PD patients, small solute transport decreased, while ultra-filtration increased. This suggests that frequent peritonitis leads to an increase of the vascular peritoneal surface area without all the structural membrane alterations that may develop after long-term PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2014.00115","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T02:05:25Z","timestamp":1415930725000},"page":"33-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["The Mutual Relationship between Peritonitis and Peritoneal Transport"],"prefix":"10.1177","volume":"36","author":[{"given":"Sadie","family":"van Esch","sequence":"first","affiliation":[{"name":"Division of Nephrology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"St. Elisabeth Hospital, Nephrology Department and Internal Medicine, Tilburg, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk T.N.","family":"van Diepen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk G.","family":"Struijk","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Dianet, Amsterdam-Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond T.","family":"Krediet","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"bibr1-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.99"},{"key":"bibr2-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1981.40"},{"key":"bibr3-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1987.tb01224.x"},{"key":"bibr4-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(98)90047-6"},{"key":"bibr5-pdi.2014.00115","first-page":"686","volume":"122","author":"Zemel D.","year":"1993","journal-title":"J Lab Clin Med"},{"key":"bibr6-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1341055"},{"key":"bibr7-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80814-6"},{"key":"bibr8-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027318"},{"key":"bibr9-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1177\/089686080002000617"},{"key":"bibr10-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04420413"},{"key":"bibr11-pdi.2014.00115","author":"Van Diepen A.T.N.","year":"2014","journal-title":"Perit Dial Int"},{"key":"bibr12-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh793"},{"key":"bibr13-pdi.2014.00115","first-page":"264","volume-title":"Peritoneal Dialysis.","author":"Vas S.","year":"1981"},{"key":"bibr14-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00049"},{"key":"bibr15-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/16.6.789"},{"key":"bibr16-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.363"},{"key":"bibr17-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1177\/089686080302300507"},{"key":"bibr18-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.188"},{"key":"bibr19-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00815.x"},{"key":"bibr20-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1159\/000183652"},{"key":"bibr21-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.91"},{"key":"bibr22-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1177\/089686088900900104"},{"key":"bibr23-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1177\/089686089101100306"},{"key":"bibr24-pdi.2014.00115","first-page":"97","volume":"37","author":"Zemel D.","year":"1992","journal-title":"Clin Nephrol"},{"key":"bibr25-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.8.1480"},{"key":"bibr26-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00357.x"},{"key":"bibr27-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00326"},{"key":"bibr28-pdi.2014.00115","doi-asserted-by":"publisher","DOI":"10.1159\/000314659"},{"key":"bibr29-pdi.2014.00115","unstructured":"ZemelD., StruijkD.G., KredietR.T., KoomenG.C.M., AriszL. 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