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However, long-term PD can lead to morphological and functional changes in the peritoneum; in particular, peritoneal fibrosis has become one of the most common complications that ultimately results in ultrafiltration failure (UFF) and discontinuation of PD. Several factors and mechanisms such as inflammation and overproduction of transforming growth factor-\u03b21 have been implicated in the development of peritoneal fibrosis, but there is no effective therapy to prevent or delay this process. Recent studies have shown that activation of multiple receptor tyrosine kinases (RTKs) is associated with the development and progression of tissue fibrosis in various organs, and there are also reports indicating the involvement of some RTKs in peritoneal fibrosis. This review will describe the role and mechanisms of RTKs in peritoneal fibrosis and discuss the possibility of using them as therapeutic targets for prevention and treatment of this complication.<\/jats:p>","DOI":"10.3747\/pdi.2014.00171","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T14:10:57Z","timestamp":1444313457000},"page":"497-505","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Tyrosine Kinase Receptors in Peritoneal Fibrosis"],"prefix":"10.1177","volume":"35","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital, Tongji University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shougang","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital, Tongji University, Shanghai, 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