{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:39:48Z","timestamp":1785555588005,"version":"3.56.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The use of pH-neutral peritoneal dialysis (PD) fluids low in glucose degradation products (GDP) may better preserve the peritoneal membrane and have fewer systemic effects. The effects of conversion from conventional to neutral-pH, low-GDP PD fluids in prevalent patients are unclear. Few studies on the role of neutral-pH, low-GDP PD have studied residual renal function, ultrafiltration, peritonitis incidence and technique failure, transport characteristics, and local and systemic markers of inflammation in prevalent PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a multi-center open-label randomized clinical trial (RCT), we randomly assigned 40 of 78 stable continuous ambulatory PD (CAPD) and automated PD (APD) patients to treatment with bicarbonate\/lactate, neutral-pH, low-GDP PD fluid (Physioneal; Baxter Healthcare Corporation, Deerfield, IL, USA) and compared them with 38 patients continuing their current standard lactate-buffered PD fluid (PDF) (Dianeal; Baxter Healthcare Corporation, Deerfield, IL, USA) during 2 years. Primary outcome was residual renal function (RRF) and ultrafiltration (UF) during peritoneal equilibration test (PET); peritonitis incidence was a secondary outcome. Furthermore, clinical parameters as well as several biomarkers in effluents and serum were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow-up, RRF did not differ between the groups. In the Physioneal group ultrafiltration (UF) during PET remained more or less stable (-20 mL [confidence interval (CI): -163.5 \u2013 123.5 mL]; p = 0.7 over 24 months), whereas it declined in the Dianeal group (-243 mL [CI: -376.6 to -109.4 mL]; p &lt; 0.0001 over 24 months), resulting in a difference of 233.7 mL [95% CI 41.0 \u2013 425.5 mL]; p = 0.017 between the groups at 24 months. The peritonitis rate was lower in the Physioneal group: adjusted odds ratio (OR) 0.38 (0.15 \u2013 0.97) p = 0.043. No differences were observed between the 2 groups in peritoneal adequacy or transport characteristics nor effluent markers of local inflammation (cancer antigen [CA]125, hyaluronan [HA], vascular endothelial growth factor [VEGF], macrophage chemo-attractant protein [MCP]-1, HA and transforming growth factor [TGF]\u03b2\u20131).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In prevalent PD patients, our study did not find a difference in RRF after conversion from conventional to neutral-pH, low-GDP PD fluids, although there is a possibility that the study was underpowered to detect a difference. Decline in UF during standardized PET was lower after 2 years in the Physioneal group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2015.00031","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T21:00:41Z","timestamp":1490648441000},"page":"273-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Conversion to a Bicarbonate\/Lactate-Buffered, Neutral-PH, LOW-GDP PD Regimen in Prevalent PD: A 2-Year Randomized Clinical Trial"],"prefix":"10.1177","volume":"37","author":[{"given":"Karima","family":"Farhat","sequence":"first","affiliation":[{"name":"VU University Medical Center, Department of Internal Medicine, Hoofddorp, The Netherlands"},{"name":"Department of Molecular Cell Biology and Immunology, Amsterdam, The Netherlands; and Spaarnegasthuis, Department of Internal Medicine, Hoofddorp, The 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.J.","family":"Beelen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Amsterdam, The Netherlands; VU University Medical Center, Department of Internal Medicine, Hoofddorp, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans J.","family":"van Ittersum","sequence":"additional","affiliation":[{"name":"VU University Medical Center, Department of Internal Medicine, Hoofddorp, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"bibr1-pdi.2015.00031","doi-asserted-by":"publisher","DOI":"10.1159\/000223803"},{"key":"bibr2-pdi.2015.00031","first-page":"S28","volume":"56","author":"Lameire N.","year":"1996","journal-title":"Kidney Int 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