{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:02:29Z","timestamp":1780628549537,"version":"3.54.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peritoneal dialysis (PD) has limited power for liquid extraction (ultrafiltration), so fluid overload remains a major cause of treatment failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We present steady concentration peritonal dialysis (SCPD), which increases ultrafiltration of PD exchanges by maintaining a constant peritoneal glucose concentration. This is achieved by infusing 50% glucose solution at a constant rate (typically 40 mL\/h) during the 4-hour dwell of a 2-L 1.36% glucose exchange. We treated 21 fluid overload episodes on 6 PD patients with high or average-high peritoneal transport characteristics who refused hemodialysis as an alternative. Each treatment consisted of a single session with 1 to 4 SCPD exchanges (as needed).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ultrafiltration averaged 653 \u00b1 363 mL\/4 h \u2014 twice the ultrafiltration of the peritoneal equilibration test (PET) (300 \u00b1 251 mL\/4 h, p &lt; 0.001) and 6-fold the daily ultrafiltration (100 \u00b1 123 mL\/4 h, p &lt; 0.001). Serum and peritoneal glucose stability and dialysis efficacy were excellent (glycemia 126 \u00b1 25 mg\/dL, peritoneal glucose 1,830 \u00b1 365 mg\/dL, D\/P creatinine 0.77 \u00b1 0.08). The treatment reversed all episodes of fluid overload, avoiding transfer to hemodialysis. Ultrafiltration was proportional to fluid overload ( p &lt; 0.01) and inversely proportional to final peritoneal glucose concentration ( p &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This preliminary clinical experience confirms the potential of SCPD to safely and effectively increase ultrafiltration of PD exchanges. It also shows peritoneal transport in a new dynamic context, enhancing the influence of factors unrelated to the osmotic gradient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2016.00007","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T22:53:53Z","timestamp":1465512833000},"page":"555-561","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["A New Method to Increase Ultrafiltration in Peritoneal Dialysis: Steady Concentration Peritoneal Dialysis"],"prefix":"10.1177","volume":"36","author":[{"given":"Vicente","family":"P\u00e9rez-D\u00edaz","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Cl\u00ednico Universitario de Valladolid, Spain"},{"name":"Department of Medicine, Dermatology and Toxicology, Facultad de Medicina, Universidad de Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"P\u00e9rez-Escudero","sequence":"additional","affiliation":[{"name":"Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sanz-Ballesteros","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cl\u00ednico Universitario de Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Rodr\u00edguez-Portela","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cl\u00ednico Universitario de Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Valenciano-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cl\u00ednico Universitario de Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Palomo-Aparicio","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cl\u00ednico Universitario de Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Hern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Complejo Asistencial de Palencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Universitario Rio Hortega de Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Gordillo-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cl\u00ednico Universitario de Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortensia","family":"Marcos-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Hospital Cl\u00ednico Universitario de Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"bibr1-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp132"},{"key":"bibr2-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00233"},{"key":"bibr3-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1159\/000368972"},{"key":"bibr4-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00008"},{"key":"bibr5-pdi.2016.00007","first-page":"122","volume-title":"Peritoneal Dialysis.","author":"Pyle W.K.","year":"1985"},{"key":"bibr6-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.196"},{"key":"bibr7-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-78940-8_6"},{"key":"bibr8-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1177\/089686089701702S12"},{"key":"bibr9-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1177\/089686080902900410"},{"key":"bibr10-pdi.2016.00007","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/089686080302300407","volume":"23","author":"Freida P.","year":"2003","journal-title":"Perit Dial Int"},{"key":"bibr11-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1177\/089686080502503S26"},{"key":"bibr12-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1159\/000093625"},{"key":"bibr13-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1159\/000337854"},{"key":"bibr14-pdi.2016.00007","first-page":"127","volume":"15","author":"Kawanishi H.","year":"1999","journal-title":"Adv Perit Dial"},{"key":"bibr15-pdi.2016.00007","first-page":"62","volume":"18","author":"Kawanishi H.","year":"2002","journal-title":"Adv Perit Dial"},{"key":"bibr16-pdi.2016.00007","first-page":"125","volume":"7","author":"Jimeno A.","year":"1987","journal-title":"Nefrolog\u00eda"},{"key":"bibr17-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1159\/000184298"},{"issue":"3","key":"bibr18-pdi.2016.00007","first-page":"75","volume":"8","author":"De Alvaro F.","year":"1988","journal-title":"Nefrolog\u00eda"},{"key":"bibr19-pdi.2016.00007","unstructured":"Pelaz Salom\u00f3nA. Administraci\u00f3n intraperitoneal de nutrientes. Nuevo m\u00e9todo de nutrici\u00f3n parenteral en humanos. Tesis doctoral. Universidad de Valladolid 1991. Available from https:\/\/sites.google.com\/site\/nutricionperitoneal\/bibliografia."},{"key":"bibr20-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1177\/089686080602600419"},{"key":"bibr21-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00887.x"},{"key":"bibr22-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn176"},{"key":"bibr23-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1177\/089686080902900408"},{"key":"bibr24-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1177\/089686080902900406"},{"key":"bibr25-pdi.2016.00007","first-page":"46","volume":"9","author":"Durand P.Y.","year":"1993","journal-title":"Adv Perit Dial"},{"key":"bibr26-pdi.2016.00007","first-page":"294","volume":"10","author":"Fischbach M.","year":"1994","journal-title":"Adv Perit Dial"},{"key":"bibr27-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1177\/089686080502500409"},{"key":"bibr28-pdi.2016.00007","first-page":"392","volume-title":"Handbook of Dialysis","author":"Blake P.G.","year":"2015"},{"key":"bibr29-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1159\/000223773"},{"key":"bibr30-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)31869-4"},{"key":"bibr31-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113207"},{"key":"bibr32-pdi.2016.00007","first-page":"41","volume":"9","author":"Abensur H.","year":"1993","journal-title":"Adv Perit Dial"},{"key":"bibr33-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.430"},{"key":"bibr34-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.3109\/00365518009091957"},{"key":"bibr35-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.195"},{"key":"bibr36-pdi.2016.00007","first-page":"198","volume":"2","author":"Krediet R.T.","year":"1988","journal-title":"Nephrol Dial Transplant"},{"key":"bibr37-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1159\/000170038"},{"key":"bibr38-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1177\/089686080602600307"},{"key":"bibr39-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2015.00144"},{"issue":"1","key":"bibr40-pdi.2016.00007","first-page":"S5","volume":"5","author":"Freida P.","year":"1995","journal-title":"Le Bulletin de la dialyse p\u00e9riton\u00e9ale"},{"key":"bibr41-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00146"},{"key":"bibr42-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12350"},{"key":"bibr43-pdi.2016.00007","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00286"}],"container-title":["Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3747\/pdi.2016.00007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3747\/pdi.2016.00007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3747\/pdi.2016.00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:23:27Z","timestamp":1777613007000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3747\/pdi.2016.00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.3747\/pdi.2016.00007"],"URL":"https:\/\/doi.org\/10.3747\/pdi.2016.00007","relation":{},"ISSN":["0896-8608","1718-4304"],"issn-type":[{"value":"0896-8608","type":"print"},{"value":"1718-4304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}