{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:20:26Z","timestamp":1777890026065,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucose is the most commonly used osmotic medium in peritoneal dialysis (PD) solutions, and its use has been associated with both local and systemic adverse effects. Previous, single-center, observational cohort studies have reported conflicting findings regarding whether a relationship exists between peritoneal glucose exposure and peritoneal small solute transport rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this secondary analysis of the balANZ multi-center, multinational, randomized controlled trial of a neutral pH, ultra-low glucose degradation product (biocompatible) versus conventional PD solutions over a 2-year period, the relationship between time varying peritoneal glucose exposure and change in peritoneal solute transport rate, (measured as dialysate to plasma creatinine ratio at 4 hours [D:PCr\n                      <jats:sub>4h<\/jats:sub>\n                      ]), was evaluated using multivariable, multilevel linear regression. Baseline peritoneal glucose exposure was also assessed as either a continuous or categorical variable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 165 patients (age 58.1 \u00b1 14.2 years, 55% male, 33% diabetic). Peritoneal glucose exposure increased over time (coefficient 1.49, 95% confidence interval [CI] 1.07 \u2013 1.92 and was not significantly associated with change in D:PCr\n                      <jats:sub>4h<\/jats:sub>\n                      (coefficient 0.00004, 95% CI -0.0001 \u2013 0.0002, p = 0.68). Similar results were found when peritoneal glucose exposure was examined as a baseline continuous or categorical variable. A significant 2-way interaction was observed with PD solution type, whereby a progressive increase in D:PCr\n                      <jats:sub>4h<\/jats:sub>\n                      was seen in the patients receiving conventional PD solution, but not in those receiving biocompatible solution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increases in peritoneal solute transport rate in PD patients over time were not associated with peritoneal glucose exposure, although a strong and positive association with PD solution glucose degradation product content was identified. Peritoneal glucose exposure may be a less important consideration than peritoneal glucose degradation product exposure with respect to peritoneal membrane function over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2017.00223","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T12:24:33Z","timestamp":1533644673000},"page":"349-355","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Associations between Peritoneal Glucose Exposure, Glucose Degradation Product Exposure, and Peritoneal Membrane Transport Characteristics in Peritoneal Dialysis Patients: Secondary Analysis of the\n                    <i>bal<\/i>\n                    ANZ Trial"],"prefix":"10.1177","volume":"38","author":[{"given":"Melissa S.","family":"Nataatmadja","sequence":"first","affiliation":[{"name":"Department of Nephrology, Princess Alexandra Hospital, Brisbane, 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M.","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia"},{"name":"Australasian Kidney Trials Network, School of Medicine, University of Queensland, Brisbane, Australia"},{"name":"Translational Research Institute, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeoungjee","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia"},{"name":"Australasian Kidney Trials Network, School of Medicine, University of Queensland, Brisbane, Australia"},{"name":"Translational Research Institute, Brisbane, 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