{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:18:46Z","timestamp":1777889926967,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infections caused by ceftazidime-resistant Pseudomonas and extended-spectrum beta-lactamase (ESBL)-producing gram-negative bacteria are increasing worldwide. Meropenem and piperacillin\/tazobactam (PIP\/TZB) are recommended for the treatment of peritoneal dialysis-associated peritonitis (PDAP) caused by ceftazidime-resistant Pseudomonas and other resistant gram-negative bacteria. Patients may also receive intraperitoneal heparin to prevent occlusion of their catheters. However, the stability of meropenem or PIP\/TZB, in combination with heparin, in different types of peritoneal dialysis (PD) solutions used in clinical practice is currently unknown. Therefore, we investigated the stability of meropenem and PIP\/TZB, each in combination with heparin, in different PD solutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 15 PD bags (3 bags for each type of PD solution) containing meropenem and heparin and 24 PD bags (3 bags for each type of PD solution) containing PIP\/TZB and heparin were prepared and stored at 4\u00b0C for 168 hours. The same bags were stored at 25\u00b0C for 3 hours followed by 10 hours at 37\u00b0C. An aliquot withdrawn before storage and at defined time points was analyzed for the concentration of meropenem, PIP, TZB, and heparin using high-performance liquid chromatography. Samples were also analysed for particle content, pH and color change, and the anticoagulant activity of heparin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Meropenem and heparin retained more than 90% of their initial concentration in 4 out of 5 types of PD solutions when stored at 4\u00b0C for 168 hours, followed by storage at 25\u00b0C for 3 hours and then at 37\u00b0C for 10 hours. Piperacillin\/tazobactam and heparin were found to be stable in all 8 types of PD solutions when stored under the same conditions. Heparin retained more than 98% of its initial anticoagulant activity throughout the study period. No evidence of particle formation, color change, or pH change was observed at any time under the storage conditions employed in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides clinically important information on the stability of meropenem and PIP\/TZB, each in combination with heparin, in different PD solutions. The use of meropenem-heparin admixed in pH-neutral PD solutions for the treatment of PDAP should be avoided, given the observed sub-optimal stability of meropenem.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3747\/pdi.2017.00274","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T14:35:47Z","timestamp":1531233347000},"page":"430-440","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Stability of Meropenem and Piperacillin\/Tazobactam with Heparin in Various Peritoneal Dialysis Solutions"],"prefix":"10.1177","volume":"38","author":[{"given":"Karryl","family":"Mendes","sequence":"first","affiliation":[{"name":"Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harmanjeet","family":"Harmanjeet","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Sedeeq","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Modi","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy","family":"Wanandy","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia"},{"name":"Department of Pharmacy, Royal Hobart Hospital, Hobart, Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Tabish R.","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long C.","family":"Ming","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia"},{"name":"School of Pharmacy, KPJ Healthcare University College, Nilai, Negeri Sembilan, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald L.","family":"Castelino","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia"},{"name":"School of Nursing, Regional Dialysis Centre, Blacktown Hospital, Blacktown, New South Wales, Australia"},{"name":"Peritoneal Dialysis Unit, Regional Dialysis Centre, Blacktown Hospital, Blacktown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Sud","sequence":"additional","affiliation":[{"name":"Peritoneal Dialysis Unit, Regional Dialysis 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