{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:18:16Z","timestamp":1787030296325,"version":"build-2736575974"},"reference-count":65,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perit Dial Int"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Peritoneal protein loss (PPL) through peritoneal effluent has been a well-recognized detrimental result of peritoneal dialysis (PD) treatment since its inception. Investigation has focused mainly on PPL quantitative and qualitative determinations and evaluation of its prognostic value.<\/jats:p>\n                  <jats:p>A comprehensive review of the pathophysiology of PPL (3-pore model revisited), methods of quantification, dialysate protein composition, and impact on clinical outcomes is presented herein. The author summarizes a brief analysis of associated cardiovascular disease and nutritional consequences, exploring the controversial cause-effect on mortality and technique failure.<\/jats:p>\n                  <jats:p>Therapeutic modalities aiming to reduce PPL (angiotensin-converting enzyme inhibitors [ACEI]s and vitamin D therapies) were explored, although it is unclear whether PPL represents a valid therapeutic target or, on the other hand, is solely a manifestation of endothelial dysfunction.<\/jats:p>","DOI":"10.3747\/pdi.2018.00138","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T19:35:18Z","timestamp":1557862518000},"page":"201-209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Peritoneal Protein Loss, Leakage or Clearance in Peritoneal Dialysis, Where do we Stand?"],"prefix":"10.1177","volume":"39","author":[{"given":"Anabela Malho","family":"Guedes","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Nefrologia, Centro Hospitalar Universit\u00e1rio do Algarve, Faro, Portugal; Algarve Biomedical Center, Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"bibr1-pdi.2018.00138","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(08)04"},{"key":"bibr2-pdi.2018.00138","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1981.57"},{"key":"bibr3-pdi.2018.00138","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/97272"},{"key":"bibr4-pdi.2018.00138","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.167"},{"issue":"1","key":"bibr5-pdi.2018.00138","first-page":"27","volume":"2","author":"Dombros N.","year":"1982","journal-title":"Perit Dial 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