{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:35Z","timestamp":1790885555615,"version":"4.1.0"},"reference-count":16,"publisher":"Baishideng Publishing Group Inc.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2008]]},"DOI":"10.3748\/wjg.14.1108","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T01:21:40Z","timestamp":1203556900000},"page":"1108","source":"Crossref","is-referenced-by-count":20,"title":["Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fi brosis"],"prefix":"10.3748","volume":"14","author":[{"given":"Nuket","family":"Mas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker","family":"Tasci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilgin","family":"Comert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Ocal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Refi k","family":"Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Gressner AM. The cell biology of liver fibrogenesis-an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell Tissue Res 1998;292:447-452.","DOI":"10.1007\/s004410051073"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Bataller R, Brenner DA. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 2001;21:437-451.","DOI":"10.1055\/s-2001-17558"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Poo JL, Feldmann G, Erlinger S, Braillon A, Gaudin C, Dumont M, Lebrec D. Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat. Gastroenterology 1992;102:1752-1759.","DOI":"10.1016\/0016-5085(92)91739-Q"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Tasci I, Mas MR, Vural SA, Comert B, Alcigir G, Serdar M, Mas N, Isik AT, Ates Y. Rat liver fibrosis regresses better with pegylated interferon alpha2b and ursodeoxycholic acid treatments than spontaneous recovery. Liver Int 2006;26:261-268.","DOI":"10.1111\/j.1478-3231.2005.01210.x"},{"key":"ref5","unstructured":"Nishio A, Keeffe EB, Ishibashi H, Gershwin EM. Diagnosis and treatment of primary biliary cirrhosis. Med Sci Monit 2000;6:181-193."},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Angulo P, Batts KP, Therneau TM, Jorgensen RA, Dickson ER, Lindor KD. Long-term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis. Hepatology 1999;29:644-647.","DOI":"10.1002\/hep.510290301"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Corpechot C, Carrat F, Bonnand AM, Poupon RE, Poupon R. The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis. Hepatology 2000;32:1196-1199.","DOI":"10.1053\/jhep.2000.20240"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Koga H, Sakisaka S, Ohishi M, Sata M, Tanikawa K. Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis. Hepatology 1997;25:1077-1084.","DOI":"10.1002\/hep.510250505"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Guicciardi ME, Gores GJ. Is ursodeoxycholate an antiapoptotic drug? Hepatology 1998;28:1721-1723.","DOI":"10.1002\/hep.510280639"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Rodrigues CM, Fan G, Wong PY, Kren BT, Steer CJ. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production. Mol Med 1998;4:165-178.","DOI":"10.1007\/BF03401914"},{"key":"ref11","unstructured":"Ates Y, Mas MR, Mas N, Tasci I, Comert B, Isik AT, Yener N. Acinar cell ultrastructure after taurine treatment in rat acute necrotizing pancreatitis. Saudi Med J 2006;27:446-452."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Mas N, Isik AT, Mas MR, Comert B, Tasci I, Deveci S, Ozyurt M, Ates Y, Yamanel L, Doruk H. Hyperbaric oxygen-induced changes in bacterial translocation and acinar ultrastructure in rat acute necrotizing pancreatitis. J Gastroenterol 2005;40:980-986.","DOI":"10.1007\/s00535-005-1653-5"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Gressner AM, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med 2006;10:76-99.","DOI":"10.1111\/j.1582-4934.2006.tb00292.x"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Neuman MG, Cameron RG, Haber JA, Katz GG, Blendis LM. An electron microscopic and morphometric study of ursodeoxycholic effect in primary biliary cirrhosis. Liver 2002;22:235-244.","DOI":"10.1046\/j.0106-9543.2002.01640.x"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Rodrigues CM, Fan G, Ma X, Kren BT, Steer CJ. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Invest 1998;101:2790-2799.","DOI":"10.1172\/JCI1325"},{"key":"ref16","unstructured":"Hernandez-Munoz R, Diaz-Munoz M, Lopez V, Barrera FL, Yanez L, Vidrio S, Fraustro AA, De Sanchez VC. Balance Between Oxidative Damage and Proliferative Potential in an Experimental Rat Model of CCl4-Induced Cirrhosis: Protective Role of Adenosine Administration. Hepatology 1997;26:1100-1110."}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v14\/i7\/1108.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T05:15:57Z","timestamp":1557292557000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v14\/i7\/1108.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.14.1108","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]}}}