{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:02:34Z","timestamp":1789524154543,"version":"build-2803163510"},"reference-count":23,"publisher":"Baishideng Publishing Group Inc.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2008]]},"DOI":"10.3748\/wjg.14.1389","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T08:05:02Z","timestamp":1211357102000},"page":"1389","source":"Crossref","is-referenced-by-count":99,"title":["Liver histology in ICU patients dying from sepsis: A clinico-pathological study"],"prefix":"10.3748","volume":"14","author":[{"given":"John","family":"Koskinas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias P","family":"Gomatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina G","family":"Tiniakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Memos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Boutsikou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aspasia","family":"Garatzioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Archimandritis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Betrosian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Jacobi J. Pathophysiology of sepsis. Am J Health Syst Pharm 2002;59 Suppl 1:S3-S8.","DOI":"10.1093\/ajhp\/59.suppl_1.S3"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Vermillion SE, Gregg JA, Baggenstoss AH, Bartholomew LG. Jaundice associated with bacteremia. Arch Intern Med 1969;124:611-618.","DOI":"10.1001\/archinte.1969.00300210093014"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Pastor CM, Billiar TR, Losser MR, Payen DM. Liver injury during sepsis. J Crit Care 1995;10:183-197.","DOI":"10.1016\/0883-9441(95)90010-1"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Banks JG, Foulis AK, Ledingham IM, Macsween RN. Liver function in septic shock. J Clin Pathol 1982;35:1249-1252.","DOI":"10.1136\/jcp.35.11.1249"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA. Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group. Crit Care Med 1989;17:389-393.","DOI":"10.1097\/00003246-198905000-00002"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004;32:858-873.","DOI":"10.1097\/01.CCM.0000117317.18092.E4"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-1321.","DOI":"10.1002\/hep.20701"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Sikuler E, Guetta V, Keynan A, Neumann L, Schlaeffer F. Abnormalities in bilirubin and liver enzyme levels in adult patients with bacteremia. A prospective study. Arch Intern Med 1989;149:2246-2248.","DOI":"10.1001\/archinte.1989.00390100070017"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Zimmerman HJ, Fang M, Utili R, Seeff LB, Hoofnagle J. Jaundice due to bacterial infection. Gastroenterology 1979;77:362-374.","DOI":"10.1016\/0016-5085(79)90293-2"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Vermillion SE, Gregg JA, Baggenstoss AH, Bartholomew LG. Jaundice associated with bacteremia. Arch Intern Med 1969;124:611-618.","DOI":"10.1001\/archinte.1969.00300210093014"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Lefkowitch JH. Bile ductular cholestasis: an ominous histopathologic sign related to sepsis and &ldquo;cholangitis lenta&rdquo;. Hum Pathol 1982;13:19-24.","DOI":"10.1016\/S0046-8177(82)80134-2"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Lysova NL, Gurevich LE, Trusov OA, Shchegolev AI, Mishnev OD. Immunohistochemical characteristics of the liver in patients with peritonitis (early autopsy). Bull Exp Biol Med 2001;132:1125-1129.","DOI":"10.1023\/A:1017993214196"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Vyberg M, Poulsen H. Abnormal bile duct epithelium accompanying septicaemia. Virchows Arch A Pathol Anat Histopathol 1984;402:451-458.","DOI":"10.1007\/BF00734641"},{"key":"ref14","unstructured":"Scheuer PJ, Lefkowitch JH. Liver biopsy interpretation. 7th ed Philadelphia: Elsevier Saunders; 2006;331-332."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Hirata K, Ikeda S, Honma T, Mitaka T, Furuhata T, Katsuramaki T, Hata F, Mukaiya M. Sepsis and cholestasis: basic findings in the sinusoid and bile canaliculus. J Hepatobiliary Pancreat Surg 2001;8:20-26.","DOI":"10.1007\/s005340170047"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Crawford JM, Boyer JL. Clinicopathology conferences: inflammation-induced cholestasis. Hepatology 1998;28:253-260.","DOI":"10.1002\/hep.510280133"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Lefkowitch JH. Histological assessment of cholestasis. Clin Liver Dis 2004;8:27-40.","DOI":"10.1016\/S1089-3261(03)00138-7"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Moseley RH. Sepsis-associated cholestasis. Gastroenterology 1997;112:302-306.","DOI":"10.1016\/S0016-5085(97)70250-6"},{"key":"ref19","unstructured":"Burt AD. Liver pathology associated with diseases of other organs or systems. MacSween&rsquo;s Pathology of the Liver. 5th ed London: Churchill Livingstone; 2007;881-932."},{"key":"ref20","unstructured":"Ludwig J, Batts KP. Practical liver biopsy interpretation: diagnostic algorithms. 2nd ed Chicago: ASCP Press; 1998;53-54."},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Cone LA, Woodard DR, Schlievert PM, Tomory GS. Clinical and bacteriologic observations of a toxic shock-like syndrome due to Streptococcus pyogenes. N Engl J Med 1987;317:146-149.","DOI":"10.1056\/NEJM198707163170305"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Ceydeli A, Condon MR, Siegel JH. The septic abscess wall: a cytokine-generating organ associated with portal venous cytokinemia, hepatic outflow fibrosis, sinusoidal congestion, inflammatory cell sequestration, hepatocellular lipid deposition, and focal cell death. Shock 2003;20:74-84.","DOI":"10.1097\/01.shk.0000065769.72937.2b"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"James PE, Madhani M, Roebuck W, Jackson SK, Swartz HM. Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumption. Nitric Oxide 2002;6:18-28.","DOI":"10.1006\/niox.2001.0383"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v14\/i9\/1389.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T15:06:11Z","timestamp":1557587171000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v14\/i9\/1389.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.14.1389","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]}}}