{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:44:19Z","timestamp":1770479059632,"version":"3.49.0"},"reference-count":30,"publisher":"Baishideng Publishing Group Inc.","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2008]]},"DOI":"10.3748\/wjg.14.2566","type":"journal-article","created":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T00:46:48Z","timestamp":1211244408000},"page":"2566","source":"Crossref","is-referenced-by-count":57,"title":["Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies"],"prefix":"10.3748","volume":"14","author":[{"given":"Mohammed","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Nane","family":"Khaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjum","family":"Aara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleem Ahmed","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Aejaz","family":"Habeeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalavarthy Prameela","family":"Devi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mangamoori Lakshmi","family":"Narasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitoor Mohammed","family":"Habibullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Fernandez-Checa JC, Hirano T, Tsukamoto H, Kaplowitz N. Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol 1993;10:469-475.","DOI":"10.1016\/0741-8329(93)90067-X"},{"key":"ref2","unstructured":"Schuppan D, Atkinson J, Ruehl M, Riecken EO. Alcohol and liver fibrosis--pathobiochemistry and treatment. Z Gastroenterol 1995;33:546-550."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Wang XD. Chronic alcohol intake interferes with retinoid metabolism and signaling. Nutr Rev 1999;57:51-59.","DOI":"10.1111\/j.1753-4887.1999.tb01778.x"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Wu D, Cederbaum AI. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcohol Clin Exp Res 1999;23:67-76.","DOI":"10.1111\/j.1530-0277.1999.tb04025.x"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Svensson S, Some M, Lundsjo A, Helander A, Cronholm T, Hoog JO. Activities of human alcohol dehydrogenases in the metabolic pathways of ethanol and serotonin. Eur J Biochem 1999;262:324-329.","DOI":"10.1046\/j.1432-1327.1999.00351.x"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Lieber CS. Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases. Adv Pharmacol 1997;38:601-628.","DOI":"10.1016\/S1054-3589(08)61001-7"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Torres-Duran PV, Miranda-Zamora R, Paredes-Carbajal MC, Mascher D, Ble-Castillo J, Diaz-Zagoya JC, Juarez-Oropeza MA. Studies on the preventive effect of Spirulina maxima on fatty liver development induced by carbon tetrachloride, in the rat. J Ethnopharmacol 1999;64:141-147.","DOI":"10.1016\/S0378-8741(98)00120-2"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Saxena AK, Singh B, Anand KK. Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol 1993;40:155-161.","DOI":"10.1016\/0378-8741(93)90063-B"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Lin CC, Yen MH, Lo TS, Lin JM. Evaluation of the hepatoprotective and antioxidant activity of Boehmeria nivea var. nivea and B. nivea var. tenacissima. J Ethnopharmacol 1998;60:9-17.","DOI":"10.1016\/S0378-8741(97)00122-0"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Zafar R, Mujahid Ali S. Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. J Ethnopharmacol 1998;63:227-231.","DOI":"10.1016\/S0378-8741(98)00087-7"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Saraswat B, Visen PK, Patnaik GK, Dhawan BN. <italic>Ex vivo<\/italic> and <italic>in vivo<\/italic> investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats. J Ethnopharmacol 1999;66:263-269.","DOI":"10.1016\/S0378-8741(99)00007-0"},{"key":"ref12","unstructured":"Doreswamy R, Sharma D. Plants drugs for liver disorders management. Indian drugs 1995;32:139-144."},{"key":"ref13","unstructured":"Evans DA, Subramoniam A, Rajashekaran S, Pushpangadan P. Effect of tricopuss eylanicus Gaertn, leaf extract on the energy metabolism in mice during excersize and at rest. Indian J Pharm 2002;34:32-37."},{"key":"ref14","unstructured":"Pandey G. XDravyaguna Vijanana; v I Varanasi: Krishnadas Academy; 1998;191-196."},{"key":"ref15","unstructured":"Kirtikar KR, Basu BD. Indian Medicinal Plants; v I. Allahabad India: BLM Basu Publ; 1991;633-642."},{"key":"ref16","unstructured":"The Useful Plants of India. Publication and Information Directorate. New Delhi: IR. 1986;547-553."},{"key":"ref17","unstructured":"Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants; v 2 New Delhi: CDRI Publication; 1999;609-610."},{"key":"ref18","unstructured":"Dwivedi AK, Chaudhary M, Sarine JPS. Standardisation of a new spermicidal agent sapindus saponin and its estimation in its formulation. Indian J Pharm Sci 1990;52:165-167."},{"key":"ref19","unstructured":"Castleman M. The Healing Herbs: The Ultimate guide to the curative powers of nature&rsquo;s medicine Emmaus PA: Rodale Press; 1991;305-307."},{"key":"ref20","unstructured":"Peirce A. The American Pharmaceutical Association practical guide to natural medicines New York: William Morrow and Company Inc; 1999;12."},{"key":"ref21","unstructured":"Borgia M, Sepe N, Borgia R, Ori-Bellometti M. Pharmacological activity of an herbal extract: controlled clinical study. Curr Ther Res 1981;29:525-536."},{"key":"ref22","unstructured":"Duke JA. Green Pharmacy Emmaus PA: Rodale Books; 1997;507."},{"key":"ref23","unstructured":"Wang X, Lous Z, Mikage M, Namba T. Pharmacognostical studies on the Chinese crude drug da-huang rhubarb II. Botanical origin of three unofficial da-huang. Shoyakugaku Zasshi 1988;42:302-309."},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Vogel G. New natural products and Plant drugs with Pharma-cological, Biological and Therapeutical Activity Springer Verlag: Berlin; 1977;249-265.","DOI":"10.1007\/978-3-642-66682-7_11"},{"key":"ref25","unstructured":"Kumar V, Cotran RS, Robbins SL. Cell injury and adaptation; 5th ed. Bangalore India: Prime Books Publ; 1992;3-24."},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Lee MK, Yeo H, Kim J, Kim YC. Protection of rat hepatocytes exposed to CCl4 in-vitro by cynandione A, a biacetophenone from Cynanchum wilfordii. J Pharm Pharmacol 2000;52:341-345.","DOI":"10.1211\/0022357001773896"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Kiso Y, Tohkin M, Hikino H. Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes. Planta Med 1983;49:222-225.","DOI":"10.1055\/s-2007-969855"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Johnston DE, Kroening C. Mechanism of early carbon tetrachloride toxicity in cultured rat hepatocytes. Pharmacol Toxicol 1998;83:231-239.","DOI":"10.1111\/j.1600-0773.1998.tb01475.x"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Yasuda H, Izumi N, Shimada O, Kobayakawa T, Nakanishi M. The protective effect of tinoridine against carbon tetrachloride hepatotoxicity. Toxicol Appl Pharmacol 1980;52:407-413.","DOI":"10.1016\/0041-008X(80)90335-X"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Slater TF. Free-radical mechanisms in tissue injury. Biochem J 1984;222:1-15.","DOI":"10.1042\/bj2220001"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v14\/i16\/2566.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T13:54:01Z","timestamp":1557582841000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v14\/i16\/2566.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":30,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.14.2566","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]}}}