{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:41:44Z","timestamp":1771562504620,"version":"3.50.1"},"reference-count":28,"publisher":"Baishideng Publishing Group Inc.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2008]]},"DOI":"10.3748\/wjg.14.6655","type":"journal-article","created":{"date-parts":[[2008,11,27]],"date-time":"2008-11-27T12:28:15Z","timestamp":1227788895000},"page":"6655","source":"Crossref","is-referenced-by-count":32,"title":["Innate immune reactivity of the liver in rats fed a cholinedeficient L-amino-acid-defined diet"],"prefix":"10.3748","volume":"14","author":[{"given":"Hideto","family":"Kawaratani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiro","family":"Tsujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuteru","family":"Kitade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Yoshiji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980;55:434-438.","DOI":"10.1016\/S0025-6196(24)00530-5"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Day CP, James OF. Steatohepatitis: a tale of two \"hits\"? Gastroenterology 1998;114:842-845.","DOI":"10.1016\/S0016-5085(98)70599-2"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Tomita K, Tamiya G, Ando S, Ohsumi K, Chiyo T, Mizutani A, Kitamura N, Toda K, Kaneko T, Horie Y. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. Gut 2006;55:415-424.","DOI":"10.1136\/gut.2005.071118"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Su GL. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 2002;283:G256-G265.","DOI":"10.1152\/ajpgi.00550.2001"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P, Musso A, De Paolis P, Capussotti L, Salizzoni M. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002;123:134-140.","DOI":"10.1053\/gast.2002.34168"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Sakaida I, Kubota M, Kayano K, Takenaka K, Mori K, Okita K. Prevention of fibrosis reduces enzyme-altered lesions in the rat liver. Carcinogenesis 1994;15:2201-2206.","DOI":"10.1093\/carcin\/15.10.2201"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Koteish A, Diehl AM. Animal models of steatosis. Semin Liver Dis 2001;21:89-104.","DOI":"10.1055\/s-2001-12932"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999;116:1413-1419.","DOI":"10.1016\/S0016-5085(99)70506-8"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999;94:2467-2474.","DOI":"10.1111\/j.1572-0241.1999.01377.x"},{"key":"ref10","unstructured":"Olynyk JK, Clarke SL. Isolation and primary culture of rat Kupffer cells. J Gastroenterol Hepatol 1998;13:842-845."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Seglen PO. Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp Cell Res 1973;82:391-398.","DOI":"10.1016\/0014-4827(73)90357-1"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Tsujimoto T, Kuriyama S, Yamazaki M, Nakatani Y, Okuda H, Yoshiji H, Fukui H. Augmented hepatocellular carcinoma progression and depressed Kupffer cell activity in rat cirrhotic livers. Int J Oncol 2001;18:41-47.","DOI":"10.3892\/ijo.18.1.41"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Bilzer M, Roggel F, Gerbes AL. Role of Kupffer cells in host defense and liver disease. Liver Int 2006;26:1175-1186.","DOI":"10.1111\/j.1478-3231.2006.01342.x"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Diehl AM. Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration. Am J Physiol Gastrointest Liver Physiol 2005;288:G1-G6.","DOI":"10.1152\/ajpgi.00376.2004"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Hansen J, Cherwitz DL, Allen JI. The role of tumor necrosis factor-alpha in acute endotoxin-induced hepatotoxicity in ethanol-fed rats. Hepatology 1994;20:461-474.","DOI":"10.1002\/hep.1840200228"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Aldred A, Nagy LE. Ethanol dissociates hormone-stimulated cAMP production from inhibition of TNF-alpha production in rat Kupffer cells. Am J Physiol 1999;276:G98-G106.","DOI":"10.1152\/ajpgi.1999.276.1.G98"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Crespo J, Cayon A, Fernandez-Gil P, Hernandez-Guerra M, Mayorga M, Dominguez-Diez A, Fernandez-Escalante JC, Pons-Romero F. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 2001;34:1158-1163.","DOI":"10.1053\/jhep.2001.29628"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005;11:183-190.","DOI":"10.1038\/nm1166"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000;406:782-787.","DOI":"10.1038\/35021228"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 1999;274:10689-10692.","DOI":"10.1074\/jbc.274.16.10689"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-397.","DOI":"10.1038\/41131"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Haziot A, Ferrero E, Kontgen F, Hijiya N, Yamamoto S, Silver J, Stewart CL, Goyert SM. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 1996;4:407-414.","DOI":"10.1016\/S1074-7613(00)80254-X"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999;162:3749-3752.","DOI":"10.4049\/jimmunol.162.7.3749"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 2001;34:101-108.","DOI":"10.1053\/jhep.2001.25350"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Hua J, Qiu de K, Li JQ, Li EL, Chen XY, Peng YS. Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury. J Gastroenterol Hepatol 2007;22:862-869.","DOI":"10.1111\/j.1440-1746.2007.04896.x"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol 2007;47:571-579.","DOI":"10.1016\/j.jhep.2007.04.019"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Tsujimoto T, Kawaratani H, Kitazawa T, Hirai T, Ohishi H, Kitade M, Yoshiji H, Uemura M, Fukui H. Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model. World J Gastroenterol 2008;14:6036-6043.","DOI":"10.3748\/wjg.14.6036"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Nagy LE. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med (Maywood) 2003;228:882-890.","DOI":"10.1177\/153537020322800803"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v14\/i43\/6655.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T18:23:19Z","timestamp":1738693399000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v14\/i43\/6655.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":28,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.14.6655","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]}}}