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Ann Intern Med 1985;102:762-765."},{"key":"ref6","unstructured":"Aoki S, Tada Y, Ohta A, Koarada S, Ushiyama O, Suzuki N, Nagasawa K. [Autoimmune hepatitis associated with mixed connective tissue disease: report of a case and a review of the literature]. Nihon Rinsho Meneki Gakkai Kaishi 2001;24:75-80."},{"key":"ref7","unstructured":"Giner Galvan V, Oltra MR, Rueda D, Esteban MJ, Redon J. Severe acute hepatitis related to hydroxychloroquine in a woman with mixed connective tissue disease. Clin Rheumatol 2007;26:971-972."},{"key":"ref8","unstructured":"Kumar M, Jain S, Sharma BC, Sarin SK. Differentiating acute hepatitis B from the first episode of symptomatic exacerbation of chronic hepatitis B. Dig Dis Sci 2006;51:594-599."},{"key":"ref9","unstructured":"Miller DJ. Seroepidemiology of viral hepatitis: correlation with clinical findings. Postgrad Med 1980;68:137-141, 144-148."},{"key":"ref10","unstructured":"Okada K, Kamiyama I, Inomata M, Imai M, Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med 1976;294:746-749."},{"key":"ref11","unstructured":"Beasley RP, Trepo C, Stevens CE, Szmuness W. The e antigen and vertical transmission of hepatitis B surface antigen. Am J Epidemiol 1977;105:94-98."},{"key":"ref12","unstructured":"Hwang LY, Roggendorf M, Beasley RP, Deinhardt F. Perinatal transmission of hepatitis B virus: role of maternal HBeAg and anti-HBc IgM. J Med Virol 1985;15:265-269."},{"key":"ref13","unstructured":"Alter HJ, Seeff LB, Kaplan PM, McAuliffe VJ, Wright EC, Gerin JL, Purcell RH, Holland PV, Zimmerman HJ. Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure. N Engl J Med 1976;295:909-913."},{"key":"ref14","unstructured":"Krugman S, Overby LR, Mushahwar IK, Ling CM, Frosner GG, Deinhardt F. Viral hepatitis, type B. Studies on natural history and prevention re-examined. N Engl J Med 1979;300:101-106."},{"key":"ref15","unstructured":"Chang MH, Hwang LY, Hsu HC, Lee CY, Beasley RP. Prospective study of asymptomatic HBsAg carrier children infected in the perinatal period: clinical and liver histologic studies. Hepatology 1988;8:374-377."},{"key":"ref16","unstructured":"Lok AS, Lai CL. A longitudinal follow-up of asymptomatic hepatitis B surface antigen-positive Chinese children. Hepatology 1988;8:1130-1133."},{"key":"ref17","unstructured":"Hoofnagle JH, Dusheiko GM, Seeff LB, Jones EA, Waggoner JG, Bales ZB. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Ann Intern Med 1981;94:744-748."},{"key":"ref18","unstructured":"Maruyama T, Schodel F, Iino S, Koike K, Yasuda K, Peterson D, Milich DR. Distinguishing between acute and symptomatic chronic hepatitis B virus infection. Gastroenterology 1994;106:1006-1015."},{"key":"ref19","unstructured":"Rodella A, Galli C, Terlenghi L, Perandin F, Bonfanti C, Manca N. Quantitative analysis of HBsAg, IgM anti-HBc and anti-HBc avidity in acute and chronic hepatitis B. J Clin Virol 2006;37:206-212."},{"key":"ref20","unstructured":"Frosner GG, Schomerus H, Wiedmann KH, Zachoval R, Bayerl B, Backer U, Gathof GA, Sugg U. Diagnostic significance of quantitative determination of hepatitis B surface antigen in acute and chronic hepatitis B infection. Eur J Clin Microbiol 1982;1:52-58."},{"key":"ref21","unstructured":"Webster GJ, Reignat S, Maini MK, Whalley SA, Ogg GS, King A, Brown D, Amlot PL, Williams R, Vergani D. Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 2000;32:1117-1124."},{"key":"ref22","unstructured":"Gayno S, Marcellin P, Loriot MA, Martinot-Peignoux M, Levy P, Erlinger S, Benhamou JP. Detection of serum HBV-DNA by polymerase chain reaction (PCR) in patients before reactivation of chronic hepatitis B. J Hepatol 1992;14:357-360."},{"key":"ref23","unstructured":"Bortolotti F, Cadrobbi P, Crivellaro C, Guido M, Rugge M, Noventa F, Calzia R, Realdi G. Long-term outcome of chronic type B hepatitis in patients who acquire hepatitis B virus infection in childhood. Gastroenterology 1990;99:805-810."},{"key":"ref24","unstructured":"Lok AS, Lai CL, Wu PC, Lau JY, Leung EK, Wong LS. Treatment of chronic hepatitis B with interferon: experience in Asian patients. 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