{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:18:06Z","timestamp":1773285486094,"version":"3.50.1"},"reference-count":33,"publisher":"Baishideng Publishing Group Inc.","issue":"33","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2009]]},"DOI":"10.3748\/wjg.15.4105","type":"journal-article","created":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T04:54:43Z","timestamp":1251953683000},"page":"4105","source":"Crossref","is-referenced-by-count":26,"title":["What is artificial endocrine pancreas? Mechanism and history"],"prefix":"10.3748","volume":"15","author":[{"given":"Kenro","family":"Nishida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenshi","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoaki","family":"Shichiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993;329:977-986.","DOI":"10.1056\/NEJM199309303291401"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 1995;28:103-117.","DOI":"10.1016\/0168-8227(95)01064-K"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:837-853.","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Albisser AM, Leibel BS, Ewart TG, Davidovac Z, Botz CK, Zingg W, Schipper H, Gander R. Clinical control of diabetes by the artificial pancreas. Diabetes 1974;23:397-404.","DOI":"10.2337\/diab.23.5.397"},{"key":"ref5","unstructured":"Shichiri M, Kawamori R, Yamasaki Y, Inoue M, Shigeta Y, Abe H. Computer algorithm for the artificial pancreatic beta cell. Artif Organs 1978;2 suupl:247-250."},{"key":"ref6","unstructured":"Goriya Y, Kawamori R, Shichiri M, Abe H. The development of an artificial beta cell system and its validation in depancreatized dogs: the physiological restoration of blood glucose homeostasis. Med Prog Technol 1979;6:99-108."},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Pfeiffer EF, Thum C, Clemens AH. The artificial beta cell--a continuous control of blood sugar by external regulation of insulin infusion (glucose controlled insulin infusion system). Horm Metab Res 1974;6:339-342.","DOI":"10.1055\/s-0028-1093841"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Nomura M, Shichiri M, Kawamori R, Yamasaki Y, Iwama N, Abe H. A mathematical insulin-secretion model and its validation in isolated rat pancreatic islets perifusion. Comput Biomed Res 1984;17:570-579.","DOI":"10.1016\/0010-4809(84)90021-1"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Kawamori R, Shichiri M, Goriya Y, Yamasaki Y, Shigeta Y, Abe H. Importance of insulin secretion based on the rate of change in blood glucose concentration in glucose tolerance, assessed by the artificial beta cell. Acta Endocrinol (Copenh) 1978;87:339-351.","DOI":"10.1530\/acta.0.0870339"},{"key":"ref10","unstructured":"Shichiri M, Kawamori R. Optimized algorithms for closed-loop glycemia control systems. Computer systems for insulin adjustment in diabetes mellitus Hedingen: Pancsienta-Verlag; 1985;171-183."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Kawamori R, Shichiri M, Kikuchi M, Yamasaki Y, Abe H. Perfect normalization of excessive glucagon responses to intravenous arginine in human diabetes mellitus with the artificial beta-cell. Diabetes 1980;29:762-765.","DOI":"10.2337\/diab.29.9.762"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Yamasaki Y, Shichiri M, Kawamori R, Goriya Y, Sasai T, Morishima T, Nomura M, Tohdo R, Abe H. Counterregulatory system in an artificial endocrine pancreas. Glucose infusion algorithm. Artif Organs 1979;3:265-270.","DOI":"10.1111\/j.1525-1594.1979.tb01061.x"},{"key":"ref13","unstructured":"Berg G, Sailer D. Treatment of diabetic ketoacidosis with a computer-controlled bedside monitoring and infusion system. Horm Metab Res Suppl 1979;3:146-150."},{"key":"ref14","unstructured":"Pfeiffer EF, Beishcher W, Kerner W. The artificial endocrine pancreas in clinical research. Horm Metab Res 1977;Suppl 7:95-114."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Okabayashi T, Hnazaki K, Nishimori I, Sugimoto T, Maeda H, Yatabe T, Dabanaka K, Kobayashi M, Yamashita K. Continuous post-operative blood glucose monitoring and control using a closed-loop system in patients undergoing hepatic resection. Dig Dis Sci 2008;53:1405-1410.","DOI":"10.1007\/s10620-007-0010-3"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Yamashita K, Okabayashi T, Yokoyama T, Yatabe T, Maeda H, Manabe M, Hanazaki K. Accuracy and reliability of continuous blood glucose monitor in post-surgical patients. Acta Anaesthesiol Scand 2009;53:66-71.","DOI":"10.1111\/j.1399-6576.2008.01799.x"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Verpooten G, De Leeuw I, Abs R. The artificial pancreas and the management of the pregnant diabetic. Eur J Obstet Gynecol Reprod Biol 1980;10:375-379.","DOI":"10.1016\/0028-2243(80)90022-2"},{"key":"ref18","unstructured":"Slama G, Klein JC, Delage A, Rottembourg J, Marouani A, Jacobs C. The use of the artificial pancreas in uremic diabetic patients. Horm Metab Res Suppl 1979;10:178-183."},{"key":"ref19","unstructured":"Magyar I, Tamás G Jr, Bányai Z. Experiences in the insulin requirement of diabetics. Endokrinologie 1981;77:79-86."},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Gin H, Erny P, Perissat J, Doutre LP, Aubertin J. Artificial pancreas in the diagnosis and treatment of insulinoma: a report of five cases. Br J Surg 1988;75:584-585.","DOI":"10.1002\/bjs.1800750630"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Hazama Y, Matsuhisa M, Ohtoshi K, Gorogawa S, Kato K, Kawamori D, Yoshiuchi K, Nakamura Y, Shiraiwa T, Kaneto H. Beneficial effects of nateglinide on insulin resistance in type 2 diabetes. Diabetes Res Clin Pract 2006;71:251-255.","DOI":"10.1016\/j.diabres.2005.08.004"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Yokoyama H, Mori K, Emoto M, Araki T, Teramura M, Mochizuki K, Tashiro T, Motozuka K, Inoue Y, Nishizawa Y. Non-oxidative glucose disposal is reduced in type 2 diabetes, but can be restored by aerobic exercise. Diabetes Obes Metab 2008;10:400-407.","DOI":"10.1111\/j.1463-1326.2007.00716.x"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223.","DOI":"10.1152\/ajpendo.1979.237.3.E214"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Shichiri M, Kawamori R, Yamasaki Y, Hakui N, Abe H. Wearable artificial endocrine pancrease with needle-type glucose sensor. Lancet 1982;2:1129-1131.","DOI":"10.1016\/S0140-6736(82)92788-X"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Shichiri M, Kawamori R, Goriya Y, Yamasaki Y, Nomura M, Hakui N, Abe H. Glycaemic control in pancreatectomized dogs with a wearable artificial endocrine pancreas. Diabetologia 1983;24:179-184.","DOI":"10.1007\/BF00250158"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Shichiri M, Kawamori R, Hakui N, Yamasaki Y, Abe H. Closed-loop glycemic control with a wearable artificial endocrine pancreas. Variations in daily insulin requirements to glycemic response. Diabetes 1984;33:1200-1202.","DOI":"10.2337\/diab.33.12.1200"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Hashiguchi Y, Sakakida M, Nishida K, Uemura T, Kajiwara K, Shichiri M. Development of a miniaturized glucose monitoring system by combining a needle-type glucose sensor with microdialysis sampling method. Long-term subcutaneous tissue glucose monitoring in ambulatory diabetic patients. Diabetes Care 1994;17:387-396.","DOI":"10.2337\/diacare.17.5.387"},{"key":"ref28","unstructured":"Nishida K, Sakakida M, Ichinose K, Uemura T, Uehara M, Kajiwara K, Miyata T, Shichiri M, Ishihara K, Nakabayashi N. Development of a ferrocene-mediated needle-type glucose sensor covered with newly designed biocompatible membrane, 2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate. Med Prog Technol 1995;21:91-103."},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Ichimori S, Nishida K, Shimoda S, Sekigami T, Matsuo Y, Ichinose K, Shichiri M, Sakakida M, Araki E. Development of a highly responsive needle-type glucose sensor using polyimide for a wearable artificial endocrine pancreas. J Artif Organs 2006;9:105-113.","DOI":"10.1007\/s10047-005-0326-8"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Sekigami T, Shimoda S, Nishida K, Matsuo Y, Ichimori S, Ichinose K, Shichiri M, Sakakida M, Araki E. Comparison between closed-loop portal and peripheral venous insulin delivery systems for an artificial endocrine pancreas. J Artif Organs 2004;7:91-100.","DOI":"10.1007\/s10047-004-0251-2"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Matsuo Y, Shimoda S, Sakakida M, Nishida K, Sekigami T, Ichimori S, Ichinose K, Shichiri M, Araki E. Strict glycemic control in diabetic dogs with closed-loop intraperitoneal insulin infusion algorithm designed for an artificial endocrine pancreas. J Artif Organs 2003;6:55-63.","DOI":"10.1007\/s100470300009"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Liang HL, Yang CF, Pan HB, Chen CK, Chang JM. Percutaneous transsplenic catheterization of the portal venous system. Acta Radiol 1997;38:292-295.","DOI":"10.1080\/02841859709172066"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Shishko PI, Kovalev PA, Goncharov VG, Zajarny IU. Comparison of peripheral and portal (via the umbilical vein) routes of insulin infusion in IDDM patients. Diabetes 1992;41:1042-1049.","DOI":"10.2337\/diab.41.9.1042"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v15\/i33\/4105.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T06:29:14Z","timestamp":1558506554000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v15\/i33\/4105.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":33,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.15.4105","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}