{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:55:12Z","timestamp":1773212112804,"version":"3.50.1"},"reference-count":32,"publisher":"Baishideng Publishing Group Inc.","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2009]]},"DOI":"10.3748\/wjg.15.4799","type":"journal-article","created":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T02:06:01Z","timestamp":1255399561000},"page":"4799","source":"Crossref","is-referenced-by-count":49,"title":["Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity"],"prefix":"10.3748","volume":"15","author":[{"given":"Sae-Kwang","family":"Ku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu-Il","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Ha","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyu-Yeol","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Bae","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeung-Sik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Soo","family":"Roh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Lan W, Zhaojun Z, Zesheng Z. Characterization of antioxidant activity of extracts from Flos Lonicerae. Drug Dev Ind Pharm 2007;33:841-847.","DOI":"10.1080\/03639040701378019"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Choi CW, Jung HA, Kang SS, Choi JS. Antioxidant constituents and a new triterpenoid glycoside from Flos Lonicerae. Arch Pharm Res 2007;30:1-7.","DOI":"10.1007\/BF02977770"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Liu JH, Ho SC, Lai TH, Liu TH, Chi PY, Wu RY. Protective effects of Chinese herbs on D-galactose-induced oxidative damage. Methods Find Exp Clin Pharmacol 2003;25:447-452.","DOI":"10.1358\/mf.2003.25.6.769650"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Tang D, Li HJ, Chen J, Guo CW, Li P. Rapid and simple method for screening of natural antioxidants from Chinese herb Flos Lonicerae Japonicae by DPPH-HPLC-DAD-TOF\/MS. J Sep Sci 2008;31:3519-3526.","DOI":"10.1002\/jssc.200800173"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Nasi A, de Moraes-Filho JP, Zilberstein B, Cecconello I, Gama-Rodrigues J. [Gastroesophageal reflux disease: comparison between patients with and without esophagitis, concerning age, gender and symptoms]. Arq Gastroenterol 2001;38:109-115.","DOI":"10.1590\/S0004-28032001000200006"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Malfertheiner P, Hallerbäck B. Clinical manifestations and complications of gastroesophageal reflux disease (GERD). Int J Clin Pract 2005;59:346-355.","DOI":"10.1111\/j.1742-1241.2005.00370.x"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Gouvea A, Costa MS, Aldighieri FC, Oliveira MA, Pereira JC, Duarte PS. [Evaluation of the usefulness of assessing pulmonary aspiration in a gastroesophageal reflux scintigraphy study]. Rev Assoc Med Bras 2007;53:257-260.","DOI":"10.1590\/S0104-42302007000300025"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Oh TY, Lee JS, Ahn BO, Cho H, Kim WB, Kim YB, Surh YJ, Cho SW, Hahm KB. Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxidants in its treatment. Free Radic Biol Med 2001;30:905-915.","DOI":"10.1016\/S0891-5849(01)00472-5"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Li Y, Wo JM, Ellis S, Ray MB, Jones W, Martin RC. A novel external esophageal perfusion model for reflux esophageal injury. Dig Dis Sci 2006;51:527-532.","DOI":"10.1007\/s10620-006-3165-4"},{"key":"ref10","unstructured":"Sun Y, Wang Y, Guan X, Feng Y, Zhao Y. [Antimicrobial properties of Flos Lonicerae against oral pathogens]. Zhongguo Zhongyao Zazhi 1996;21:242-243 inside backcover."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Nagahama K, Yamato M, Kato S, Takeuchi K. Protective effect of lafutidine, a novel H2-receptor antagonist, on reflux esophagitis in rats through capsaicin-sensitive afferent neurons. J Pharmacol Sci 2003;93:55-61.","DOI":"10.1254\/jphs.93.55"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978;52:302-310.","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"ref13","unstructured":"Beutler E. Glutathione in red blood cell metabolism. A Manual of Biochemical Methods New York: Grune & Stratton; 1975;112-114."},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Minami M, Yoshikawa H. A simplified assay method of superoxide dismutase activity for clinical use. Clin Chim Acta 1979;92:337-342.","DOI":"10.1016\/0009-8981(79)90211-0"},{"key":"ref15","unstructured":"Evans RC, Diplock AT, Laboratory techniques in biochemistry and molecular biology. In: Burtin RH, Knippenberg PH, eds. Techniques in free radical research The Netherlands, Amsterdam: Elsevier; 1991;199-201."},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982;78:206-209.","DOI":"10.1111\/1523-1747.ep12506462"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"López-De León A, Rojkind M. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 1985;33:737-743.","DOI":"10.1177\/33.8.2410480"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Wu L. Effect of chlorogenic acid on antioxidant activity of Flos Lonicerae extracts. J Zhejiang Univ Sci B 2007;8:673-679.","DOI":"10.1631\/jzus.2007.B0673"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Suzuki Y, Ishihara M, Segami T, Ito M. Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats. Jpn J Pharmacol 1998;78:435-441.","DOI":"10.1254\/jjp.78.435"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Rao CV, Vijayakumar M. Effect of quercetin, flavonoids and alpha-tocopherol, an antioxidant vitamin, on experimental reflux oesophagitis in rats. Eur J Pharmacol 2008;589:233-238.","DOI":"10.1016\/j.ejphar.2008.04.062"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Farhadi A, Fields J, Banan A, Keshavarzian A. Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer? Am J Gastroenterol 2002;97:22-26.","DOI":"10.1111\/j.1572-0241.2002.05444.x"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Das D, Banerjee RK. Effect of stress on the antioxidant enzymes and gastric ulceration. Mol Cell Biochem 1993;125:115-125.","DOI":"10.1007\/BF00936440"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 1996;313:17-29.","DOI":"10.1042\/bj3130017"},{"key":"ref24","unstructured":"Ross D. Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free-radical induced toxicity and glutathione-dependent protection. Pharmacol Ther 1988;37:231-249."},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Maity S, Vedasiromoni JR, Ganguly DK. Role of glutathione in the antiulcer effect of hot water extract of black tea (Camellia sinensis). Jpn J Pharmacol 1998;78:285-292.","DOI":"10.1254\/jjp.78.285"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Ichikawa H, Naito Y, Takagi T, Tomatsuri N, Yoshida N, Yoshikawa T. A specific peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand, pioglitazone, ameliorates gastric mucosal damage induced by ischemia and reperfusion in rats. Redox Rep 2002;7:343-346.","DOI":"10.1179\/135100002125000956"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Jiménez MD, Martín MJ, Alarcón de la Lastra C, Bruseghini L, Esteras A, Herrerías JM, Motilva V. Role of L-arginine in ibuprofen-induced oxidative stress and neutrophil infiltration in gastric mucosa. Free Radic Res 2004;38:903-911.","DOI":"10.1080\/10715760410001705168"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Sener G, Paskaloglu K, Kapucu C, Cetinel S, Contuk G, Ayano\u011flu-Dülger G. Octreotide ameliorates alendronate-induced gastric injury. Peptides 2004;25:115-121.","DOI":"10.1016\/j.peptides.2003.11.017"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Zimmerman BJ, Grisham MB, Granger DN. Role of oxidants in ischemia\/reperfusion-induced granulocyte infiltration. Am J Physiol 1990;258:G185-G190.","DOI":"10.1152\/ajpgi.1990.258.2.G185"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Sullivan GW, Sarembock IJ, Linden J. The role of inflammation in vascular diseases. J Leukoc Biol 2000;67:591-602.","DOI":"10.1002\/jlb.67.5.591"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"I\u015feri SO, Sener G, Yüksel M, Contuk G, Cetinel S, Gedik N, Yegen BC. Ghrelin against alendronate-induced gastric damage in rats. J Endocrinol 2005;187:399-406.","DOI":"10.1677\/joe.1.06432"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Hendel L. Hydroxyproline in the oesophageal mucosa of patients with progressive systemic sclerosis during omeprazole-induced healing of reflux oesophagitis. Aliment Pharmacol Ther 1991;5:471-480.","DOI":"10.1111\/j.1365-2036.1991.tb00516.x"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v15\/i38\/4799.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T04:02:37Z","timestamp":1558584157000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v15\/i38\/4799.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":32,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.15.4799","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}