{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:18:46Z","timestamp":1792646326472,"version":"4.5.0"},"reference-count":135,"publisher":"Baishideng Publishing Group Inc.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2004]]},"DOI":"10.3748\/wjg.v10.i12.1699","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T09:31:22Z","timestamp":1442655082000},"page":"1699","source":"Crossref","is-referenced-by-count":162,"title":["Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury"],"prefix":"10.3748","volume":"10","author":[{"given":"Cheng","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.37.195.505"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(62)90114-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.143.3613.1443"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104253241701"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00531-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11596"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2174\/1389201043489657"},{"key":"ref8","unstructured":"Herrmann W, Knapp JP. Hyperhomocysteinemia: a new risk factor for degenerative diseases. Clin Lab 2002;48:471-481."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/bf03351481"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(03)00062-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02278.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3204-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.1.45"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Finkelstein JD, Martin JJ, Harris BJ. Methionine metabolism in mammals. The methionine-sparing effect of cystine. J Biol Chem 1988;263:11750-11754.","DOI":"10.1016\/S0021-9258(18)37847-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8466"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2000.tb01862.x"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. J Biol Chem 1984;259:9508-9513.","DOI":"10.1016\/S0021-9258(17)42728-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0401rev"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.298"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2003.217"},{"key":"ref21","unstructured":"Mudd SH, Lev HL, Skovby F. Disorders of transsulfuration. In Scriver CR, Beaudet AL, Sly WS, Valle D. (eds), The Metabolic Basis of Inherited Disease New York: McGraw-Hill; 1995;1279&ndash;1327."},{"key":"ref22","unstructured":"Rosenblatt DS. Inherited disorders of folate transport and metabolism. In Scriver CR, Beaudet AL, Sly WS, Valle D. (eds), The Metabolic Basis of Inherited Disease New York: McGraw-Hill; 1995;3111&ndash;3128."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-111"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.10.2410"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.1.7"},{"key":"ref26","unstructured":"Jeng YL, Wu MH, Huang HB, Lin WY, You SL, Chu TY, Chen CJ, Sun CA. The methylenetetrahydrofolate reductase 677C&rarr;T polymorphism and lung cancer risk in a Chinese population. Anticancer Res 2003;23:5149-5152."},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2001.tb01173.x"},{"key":"ref28","unstructured":"Mudd SH, Levy HL, Skovby F. Disorders of transsulfation. The Metabolic Basis for Inherited Disease New York: McGraw-Hill; 1989;693."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-004-0097-3"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Wi lcke n DE L, Du dma n N PB. H o m o cy st inu ria a nd atherosclerosis. Mo-lecular genetics of coronary artery disease; candidate genes and process in atherosclerosis. Monograms in human genetics New York: Karger; 1992;311.","DOI":"10.1159\/000421520"},{"key":"ref31","unstructured":"Mudd SH, Levy HL, Kraus JP. Disorders of transsulfuration. The Metabolic and Molecular Bases of Inherited Disease New York: McGraw-Hill; 2001;2007-2056."},{"key":"ref32","unstructured":"Ueland PM, Refsum H. Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy. J Lab Clin Med 1989;114:473-501."},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9214"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022130217463"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.455"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-6047.2001.00252.x"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(99)00297-X"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2436385100"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212194200"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(199702)64:2&lt;196::AID-JCB3&gt;3.0.CO;2-S"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab 2001;281:E1095-E1100.","DOI":"10.1152\/ajpendo.2001.281.5.E1095"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.22.2717"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3570233"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Wang G, Siow YL, O K. Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-kappaB in THP-1 macrophages. Am J Physiol Heart Circ Physiol 2001;280:H2840-H2847.","DOI":"10.1152\/ajpheart.2001.280.6.H2840"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10373"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10588"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118776"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.5.1119"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1161\/hq1201.100456"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.2.422"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1156"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2003.222"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.3.465"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1021\/bi001088w"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/320454a0"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Heinecke JW, Rosen H, Suzuki LA, Chait A. The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. J Biol Chem 1987;262:10098-10103.","DOI":"10.1016\/S0021-9258(18)61082-8"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.27.17012"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Outinen PA, Sood SK, Liaw PC, Sarge KD, Maeda N, Hirsh J, Ribau J, Podor TJ, Weitz JI, Austin RC. Characterization of the stress-inducing effects of homocysteine. Biochem J 1998;332:213-221.","DOI":"10.1042\/bj3320213"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000041629.92741.DC"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114271"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Jakubowski H. Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J 1999;13:2277-2283.","DOI":"10.1096\/fasebj.13.15.2277"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2003.50033"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.10.1211"},{"key":"ref64","unstructured":"Welihinda AA, Tirasophon W, Kaufman RJ. The cellular response to protein misfolding in the endoplasmic reticulum. Gene Expr 1999;7:293-300."},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1038\/nrm829"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216886"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1379\/1466-1268(2002)007&lt;0222:TMERAA&gt;2.0.CO;2"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00203-4"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004454200"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112454200"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401378"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2004.01.004"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(96)10073-6"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, Li J, Weitz JI, Austin RC. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood 1999;94:959-967.","DOI":"10.1182\/blood.V94.3.959.415k20_959_967"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(00)00208-4"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312948200"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100747200"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00276-2"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50089"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2833"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002063200"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00462-X"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Wang XZ, Lawson B, Brewer JW, Zinszner H, Sanjay A, Mi LJ, Boorstein R, Kreibich G, Hendershot LM, Ron D. Signals from the stressed endoplasmic reticulum induce C\/EBP-homologous protein (CHOP\/GADD153). Mol Cell Biol 1996;16:4273-4280.","DOI":"10.1128\/MCB.16.8.4273"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Cai Y, Zhang C, Nawa T, Aso T, Tanaka M, Oshiro S, Ichijo H, Kitajima S. Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element. Blood 2000;96:2140-2148.","DOI":"10.1182\/blood.V96.6.2140"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6044"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5453.664"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.2.631"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.5.1585"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Lentz SR, Erger RA, Dayal S, Maeda N, Malinow MR, Heistad DD, Faraci FM. Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Am J Physiol Heart Circ Physiol 2000;279:H970-H975.","DOI":"10.1152\/ajpheart.2000.279.3.H970"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.7.1006"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1161\/hh1101.092180"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8342"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213036200"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.5.433"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0456fje"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.4.1058-1065.2001"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0650rev"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/36.3.189"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb04606.x"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1301\/00296640260184309"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01194-1"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.5.579"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.7.1220"},{"key":"ref104","doi-asserted-by":"crossref","unstructured":"Lu SC, Huang ZZ, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol 2000;279:G178-G185.","DOI":"10.1152\/ajpgi.2000.279.1.G178"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb00798.x"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180433"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(97)00134-1"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(96)00030-4"},{"key":"ref109","doi-asserted-by":"crossref","unstructured":"Barak AJ, Beckenhauer HC, Tuma DJ. Hepatic transmethylation and blood alcohol levels. Alcohol Alcohol 1991;26:125-128.","DOI":"10.1093\/oxfordjournals.alcalc.a045092"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(70)90101-3"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1976.tb52882.x"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230314"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112336399"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(01)00102-8"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/20.1.27"},{"key":"ref116","doi-asserted-by":"crossref","unstructured":"Rivera CA, Bradford BU, Seabra V, Thurman RG. Role of endotoxin in the hypermetabolic state after acute ethanol exposure. Am J Physiol 1998;275:G1252-G1258.","DOI":"10.1152\/ajpgi.1998.275.6.G1252"},{"key":"ref117","doi-asserted-by":"crossref","unstructured":"Rivera CA, Wheeler MD, Enomoto N, Thurman RG. A choline-rich diet improves survival in a rat model of endotoxin shock. Am J Physiol 1998;275:G862-G867.","DOI":"10.1152\/ajpgi.1998.275.4.G862"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613062"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.35536"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110203"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091016398"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0121com"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.1996.v24.ajhep0241504"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216787"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00041.2002"},{"key":"ref126","doi-asserted-by":"crossref","unstructured":"Xu Z, Jensen G, Yen TS. Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol 1997;71:7387-7392.","DOI":"10.1128\/JVI.71.10.7387-7392.1997"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.15.7453-7459.2002"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01300-X"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.6.3578-3585.2003"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.21.11644-11650.2003"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312144200"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200302000-00003"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-003-0014-x"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840360728"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200303000-00012"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v10\/i12\/1699.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T01:34:50Z","timestamp":1653183290000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v10\/i12\/1699.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":135,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v10.i12.1699","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2004]]}}}