{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:02:14Z","timestamp":1791090134620,"version":"4.1.0"},"reference-count":51,"publisher":"Baishideng Publishing Group Inc.","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2004]]},"DOI":"10.3748\/wjg.v10.i17.2529","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T11:24:14Z","timestamp":1442575454000},"page":"2529","source":"Crossref","is-referenced-by-count":32,"title":["Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1"],"prefix":"10.3748","volume":"10","author":[{"given":"Inma","family":"Castilla-Cort\u00e1zar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","unstructured":"Van Thiel DH. Endocrine function In The liver: biology and pathobiology. Raven Press; 1982;717-912."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310308"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Van Thiel DH, Gavaler JS, Slone FL, Cobb CF, Smith WI, Bron KM, Lester R. Is feminization in alcoholic men due in part to portal hypertension: a rat model. Gastroenterology 1980;78:81-91.","DOI":"10.1016\/0016-5085(80)90196-1"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"BENNETT HS, BAGGENSTOSS AH, BUTT HR. The testis, breast and prostate of men who die of cirrhosis of the liver. Am J Clin Pathol 1950;20:814-828.","DOI":"10.1093\/ajcp\/20.9.814"},{"key":"ref5","unstructured":"Van Steenbergen W. [Alcohol, liver cirrhosis and disorders in sex hormone metabolism]. Acta Clin Belg 1993;48:269-283."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060126"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Guechot J, Vaubourdolle M, Ballet F, Giboudeau J, Darnis F, Poupon R. Hepatic uptake of sex steroids in men with alcoholic cirrhosis. Gastroenterology 1987;92:203-207.","DOI":"10.1016\/0016-5085(87)90860-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6556.1191"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1994.tb01259.x"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Sara VR, Hall K. Insulin-like growth factors and their binding proteins. Physiol Rev 1990;70:591-614.","DOI":"10.1152\/physrev.1990.70.3.591"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0860355"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(92)90071-H"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230521"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80211-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346823"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(97)80026-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322513"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Castilla-Cortázar I, Picardi A, Tosar A, Ainzúa J, Urdaneta E, García M, Pascual M, Quiroga J, Prieto J. Effect of insulin-like growth factor I on in vivo intestinal absorption of D-galactose in cirrhotic rats. Am J Physiol 1999;276:G37-G42.","DOI":"10.1152\/ajpgi.1999.276.1.G37"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Pascual M, Castilla-Cortazar I, Urdaneta E, Quiroga J, Garcia M, Picardi A, Prieto J. Altered intestinal transport of amino acids in cirrhotic rats: the effect of insulin-like growth factor-I. Am J Physiol Gastrointest Liver Physiol 2000;279:G319-G324.","DOI":"10.1152\/ajpgi.2000.279.2.G319"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80211-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/BF03179904"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352873"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Muguerza B, Castilla-Cortázar I, García M, Quiroga J, Santidrián S, Prieto J. Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats. Biochim Biophys Acta 2001;1536:185-195.","DOI":"10.1016\/S0925-4439(01)00045-X"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Castilla-Cortázar I, Aliaga-Montilla MA, Salvador J, García M, Delgado G, González-Barón S, Quiroga J, Prieto J. Insulin-like growth factor-I restores the reduced somatostatinergic tone controlling growth hormone secretion in cirrhotic rats. Liver 2001;21:405-409.","DOI":"10.1034\/j.1600-0676.2001.210607.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1995.tb00928.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1370081"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Zhou J, Bondy C. Anatomy of the insulin-like growth factor system in the human testis. Fertil Steril 1993;60:897-904.","DOI":"10.1016\/S0015-0282(16)56294-3"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402670217"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1380107"},{"key":"ref30","unstructured":"Grizard G. [IGF (s) and testicular functions. Secretion and action of IGF-1 on Leydig cells]. Contracept Fertil Sex 1994;22:551-555."},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Lin T, Wang D, Nagpal ML, Shimasaki S, Ling N. Expression and regulation of insulin-like growth factor-binding protein-1, -2, -3, and -4 messenger ribonucleic acids in purified rat Leydig cells and their biological effects. Endocrinology 1993;132:1898-1904.","DOI":"10.1210\/endo.132.5.7682935"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod52.2.419"},{"key":"ref33","unstructured":"The Guiding Principles for Research Involving Animals. National Academy of Sciences and published by the National Institute of Health -NIH-, revised in 1991. ."},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90346-1"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1995.tb00929.x"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1042\/bj2180313"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2795(199807)50:3<273::AID-MRD3>3.0.CO;2-G"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Gutteridge JM. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 1995;41:1819-1828.","DOI":"10.1093\/clinchem\/41.12.1819"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280603"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(91)90040-3"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Mezey E. Liver disease and nutrition. Gastroenterology 1978;74:770-783.","DOI":"10.1016\/0016-5085(78)90259-7"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1230389"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3109\/01485019408987821"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod54.2.446"},{"key":"ref45","unstructured":"Prati M, Palmero S, De Marco P, Trucchi P, Fugassa E. [Effect of insulin-like growth factor I (IGF-I) on Sertoli cell metabolism in the pubescent rat]. Boll Soc Ital Biol Sper 1992;68:121-128."},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Waites GM, Gladwell RT. Physiological significance of fluid secretion in the testis and blood-testis barrier. Physiol Rev 1982;62:624-671.","DOI":"10.1152\/physrev.1982.62.2.624"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1991.tb05204.x"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1989.tb00414.x"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1660247"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.3.899"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1440073"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v10\/i17\/2529.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T12:48:27Z","timestamp":1599569307000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v10\/i17\/2529.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":51,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v10.i17.2529","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2004]]}}}