{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:09:57Z","timestamp":1788516597689,"version":"build-2803163510"},"reference-count":34,"publisher":"Baishideng Publishing Group Inc.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2004]]},"DOI":"10.3748\/wjg.v10.i7.950","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T05:32:18Z","timestamp":1509341538000},"page":"950","source":"Crossref","is-referenced-by-count":5,"title":["Effect of O-4-ethoxyl-butyl-berbamine in combination with pegylated liposomal doxorubicin on advanced hepatoma in mice"],"prefix":"10.3748","volume":"10","author":[{"given":"Bai-Jun","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Ming","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert -C-H","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","unstructured":"Zhang JH, Geng ZH, Duan JY, Chen JT, He H, Huang JY. Calmodulin antagonist-effect of berbamine and its derivatives on the cytotoxicity of normal cells. Xibao Shengwuxue Zazhi 1997;19:76-79."},{"key":"ref2","unstructured":"Liu J, Qi S, Zhu H, Zhang J, Li Z, Wang T. The effect of calmodulin antagonist berbaminederivative-EBB on hepatoma in vitro and in vivo. Chin Med J (Engl) 2002;115:759-762."},{"key":"ref3","unstructured":"Zhang JH, Mao QL, Xu NH, Du XM, Shan T, Chen JT. Effect of calmodulin antagonist on calmodulin content in organs of mice bearing tumor. Nankai Daxue Xuebao 1998;31:72-77."},{"key":"ref4","unstructured":"Zhang JH, Mao QL, Xu NH, Chen JT. Effect of berbamine de-rivative (EBB) on anticancer and immune function of tumor-bear-ing mice. Zhongcaoyao 1998;29:243-246."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200202000-00021"},{"key":"ref6","unstructured":"Forrest GL, Gonzalez B, Tseng W, Li X, Mann J. Human carbonyl reductase overexpression in the heart advances the development of doxorubicin-induced cardiotoxicity in transgenic mice. Cancer Res 2000;60:5158-5164."},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Working PK, Newman MS, Sullivan T, Yarrington J. Reduction of the cardiotoxicity of doxorubicin in rabbits and dogs by encapsulation in long-circulating, pegylated liposomes. J Pharmacol Exp Ther 1999;289:1128-1133.","DOI":"10.1016\/S0022-3565(24)38244-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.3.862"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Lim HJ, Masin D, McIntosh NL, Madden TD, Bally MB. Role of drug release and liposome-mediated drug delivery in governing the therapeutic activity of liposomal mitoxantrone used to treat human A431 and LS180 solid tumors. J Pharmacol Exp Ther 2000;292:337-345.","DOI":"10.1016\/S0022-3565(24)35297-8"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Weinstein DM, Mihm MJ, Bauer JA. Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice. J Pharmacol Exp Ther 2000;294:396-401.","DOI":"10.1016\/S0022-3565(24)39082-2"},{"key":"ref11","unstructured":"Cabanes A, Even-Chen S, Zimberoff J, Barenholz Y, Kedar E, Gabizon A. Enhancement of antitumor activity of polyethylene glycol-coated liposomal doxorubicin with soluble and liposomal interleukin 2. Clin Cancer Res 1999;5:687-693."},{"key":"ref12","unstructured":"Lyass O, Hubert A, Gabizon AA. Phase I study of doxil-cisplatin combination chemotherapy in patients with advanced malignancies. Clin Cancer Res 2001;7:3040-3046."},{"key":"ref13","unstructured":"Gabizon AA. Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet. Clin Cancer Res 2001;7:223-225."},{"key":"ref14","unstructured":"Marina NM, Cochrane D, Harney E, Zomorodi K, Blaney S, Winick N, Bernstein M, Link MP. Dose escalation and pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in children with solid tumors: a pediatric oncology group study. Clin Cancer Res 2002;8:413-418."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Wang GW, Kang YJ. Inhibition of doxorubicin toxicity in cultured neonatal mouse cardiomyocytes with elevated metallothionein levels. J Pharmacol Exp Ther 1999;288:938-944.","DOI":"10.1016\/S0022-3565(24)38044-9"},{"key":"ref16","unstructured":"Wang L, Hou BG, Hou XP, Yu ML, Yang JS. [Effects of different phospholipids on the stabilities of doxorubicin liposomes in vitro and in vivo]. Yao Xue Xue Bao 2001;36:444-447."},{"key":"ref17","unstructured":"Hong RL, Huang CJ, Tseng YL, Pang VF, Chen ST, Liu JJ, Chang FH. Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial? Clin Cancer Res 1999;5:3645-3652."},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Laverman P, Carstens MG, Boerman OC, Dams ET, Oyen WJ, van Rooijen N, Corstens FH, Storm G. Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection. J Pharmacol Exp Ther 2001;298:607-612.","DOI":"10.1016\/S0022-3565(24)29419-2"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Laverman P, Brouwers AH, Dams ET, Oyen WJ, Storm G, van Rooijen N, Corstens FH, Boerman OC. Preclinical and clinical evidence for disappearance of long-circulating characteristics of polyethylene glycol liposomes at low lipid dose. J Pharmacol Exp Ther 2000;293:996-1001.","DOI":"10.1016\/S0022-3565(24)39325-5"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Dams ET, Laverman P, Oyen WJ, Storm G, Scherphof GL, van Der Meer JW, Corstens FH, Boerman OC. Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes. J Pharmacol Exp Ther 2000;292:1071-1079.","DOI":"10.1016\/S0022-3565(24)35391-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6217"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Wang J, Zhou Y, Wen H, Levitan IB. Simultaneous binding of two protein kinases to a calcium-dependent potassium channel. J Neurosci 1999;19:RC4.","DOI":"10.1523\/JNEUROSCI.19-10-j0005.1999"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1042\/bj20020429"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00257.2001"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010238200"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/35078091"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/20200"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-3-31"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109535200"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104315200"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Wu BW, Wu Y, Wang JL, Lin JS, Yuan SY, Li A, Cui WR. Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells. World J Gastroenterol 2003;9:271-275.","DOI":"10.3748\/wjg.v9.i2.271"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70010139.x"},{"key":"ref33","unstructured":"Liu J, Sun L, Wang Q, Zheng H, Wong L. [Effects of 17 beta-estradiol on intracellular free calcium, inositol-1,4,5-trisphophate and calmodulin in human osteoblast-like osteosarcoma cell line TE85]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1999;21:105-110."},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009465200"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v10\/i7\/950.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T19:54:26Z","timestamp":1750967666000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v10\/i7\/950.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v10.i7.950","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2004]]}}}