{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:05:39Z","timestamp":1773803139148,"version":"3.50.1"},"reference-count":50,"publisher":"Baishideng Publishing Group Inc.","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2005]]},"DOI":"10.3748\/wjg.v11.i44.6910","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T13:25:02Z","timestamp":1445001902000},"page":"6910","source":"Crossref","is-referenced-by-count":28,"title":["Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model"],"prefix":"10.3748","volume":"11","author":[{"given":"Florian","family":"Graepler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb00854.x"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Austin EA, Huber BE. A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing, and expression of Escherichia coli cytosine deaminase. Mol Pharmacol 1993;43:380-387.","DOI":"10.1016\/S0026-895X(25)13624-9"},{"key":"ref3","unstructured":"Kanai F, Lan KH, Shiratori Y, Tanaka T, Ohashi M, Okudaira T, Yoshida Y, Wakimoto H, Hamada H, Nakabayashi H. In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. Cancer Res 1997;57:461-465."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1996.7.13-1567"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1995.6.7-881"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1089\/10430340050016175"},{"key":"ref7","unstructured":"Miller CR, Williams CR, Buchsbaum DJ, Gillespie GY. Intratumoral 5-fluorouracil produced by cytosine deaminase\/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. Cancer Res 2002;62:773-780."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1998.9.6-855"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1995.6.8-1055"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Huber BE, Austin EA, Richards CA, Davis ST, Good SS. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Natl Acad Sci USA 1994;91:8302-8306 DOI : 10.1073\/pnas.91.17.8302.","DOI":"10.1073\/pnas.91.17.8302"},{"key":"ref11","unstructured":"Trinh QT, Austin EA, Murray DM, Knick VC, Huber BE. Enzyme\/prodrug gene therapy: comparison of cytosine deaminase\/5-fluorocytosine versus thymidine kinase\/ganciclovir enzyme\/prodrug systems in a human colorectal carcinoma cell line. Cancer Res 1995;55:4808-4812."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1998.tb13205.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s002700010045"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(90)90026-N"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Wybranietz WA, Lauer U. Distinct combination of purification methods dramatically improves cohesive-end subcloning of PCR products. Biotechniques 1998;24:578-580.","DOI":"10.2144\/98244bm13"},{"key":"ref16","unstructured":"Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques 1989;7:980-982, 980-982, 980-982."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.33"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-2254(199907\/08)1:4<265::AID-JGM48>3.0.CO;2-D"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1997.8.1-73"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.13.1107"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/BF00391826"},{"key":"ref22","unstructured":"Erbs P, Regulier E, Kintz J, Leroy P, Poitevin Y, Exinger F, Jund R, Mehtali M. In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase\/uracil phosphoribosyltransferase fusion gene. Cancer Res 2000;60:3813-3822."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2001.0417"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700345"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.33"},{"key":"ref26","unstructured":"Kievit E, Nyati MK, Ng E, Stegman LD, Parsels J, Ross BD, Rehemtulla A, Lawrence TS. Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts. Cancer Res 2000;60:6649-6655."},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.14.6.903"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Roncarolo MG, Levings MK, Mangia P, Bordignon C, Marktel S, Bonini C, Traversar C. Characterization and modulation of the undesirable T cell-mediated responses to transgenes. Mol Ther 2002;S399.","DOI":"10.1016\/S1525-0016(16)44058-X"},{"key":"ref29","unstructured":"Kanyama H, Tomita N, Yamano T, Aihara T, Miyoshi Y, Ohue M, Sekimoto M, Sakita I, Tamaki Y, Kaneda Y. Usefulness of repeated direct intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy. Cancer Res 2001;61:14-18."},{"key":"ref30","unstructured":"Kievit E, Bershad E, Ng E, Sethna P, Dev I, Lawrence TS, Rehemtulla A. Superiority of yeast over bacterial cytosine deaminase for enzyme\/prodrug gene therapy in colon cancer xenografts. Cancer Res 1999;59:1417-1421."},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301557"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950017356"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700131"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301564"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.164"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301383"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601246"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301355"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/79463"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60807-6"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301312"},{"key":"ref42","unstructured":"Shayakhmetov DM, Li ZY, Ni S, Lieber A. Targeting of adenovirus vectors to tumor cells does not enable efficient transduction of breast cancer metastases. Cancer Res 2002;62:1063-1068."},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Gerolami R, Uch R, Faivre J, Garcia S, Hardwigsen J, Cardoso J, Mathieu S, Bagnis C, Brechot C, Mannoni P. Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV-1-derived lentiviral vectors. J Hepatol 2004;40:291-297 DOI : 10.1016\/j.jhep.2003.10.019.","DOI":"10.1016\/j.jhep.2003.10.019"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4573"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1089\/10430340050016166"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-40543"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1038\/89901"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012616"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/35038533"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2001.0491"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v11\/i44\/6910.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T01:51:53Z","timestamp":1748656313000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v11\/i44\/6910.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":50,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v11.i44.6910","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2005]]}}}