{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:39:42Z","timestamp":1784813982887,"version":"3.55.0"},"reference-count":35,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2006]]},"DOI":"10.3748\/wjg.v12.i2.259","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T05:21:20Z","timestamp":1458019280000},"page":"259","source":"Crossref","is-referenced-by-count":82,"title":["Antioxidative effect of melatonin, ascorbic acid and<i>N<\/i>-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats"],"prefix":"10.3748","volume":"12","author":[{"given":"Mukaddes","family":"E\u015frefo\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burhan","family":"Ate\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"Bat\u00e7\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukadder Ay\u015fe","family":"Selimo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199201000-00007"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Ding SP, Li JC, Jin C. A mouse model of severe acute pancreatitis induced with caerulein and lipopolysaccharide. World J Gastroenterol 2003;9:584-589.","DOI":"10.3748\/wjg.v9.i3.584"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Niederau C, Niederau M, L&uuml;then R, Strohmeyer G, Ferrell LD, Grendell JH. Pancreatic exocrine secretion in acute experimental pancreatitis. Gastroenterology 1990;99:1120-1127.","DOI":"10.1016\/0016-5085(90)90633-C"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Watanabe O, Baccino FM, Steer ML, Meldolesi J. Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis. Am J Physiol 1984;246:G457-G467.","DOI":"10.1152\/ajpgi.1984.246.4.G457"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.11.1516"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Saluja A, Saito I, Saluja M, Houlihan MJ, Powers RE, Meldolesi J, Steer M. In vivo rat pancreatic acinar cell function during supramaximal stimulation with caerulein. Am J Physiol 1985;249:G702-G710.","DOI":"10.1152\/ajpgi.1985.249.6.G702"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Steer ML, Saluja AK. Etiology and pathophysiology of acute pancreatitits. The Pancreas: Biology, Patholophysiology and Disease New York: Raven Press; 1993;593-611.","DOI":"10.1007\/978-3-642-77437-9_2"},{"key":"ref8","unstructured":"Schoenberg MH, B&uuml;chler M, Beger HG. Oxygen radicals in experimental acute pancreatitis. Hepatogastroenterology 1994;41:313-319."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198410000-00003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200003000-00008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198505000-00013"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(97)00240-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404283301706"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1998.5539"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(02)00134-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2002.6474"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Uru\u00f1uela A, Sevillano S, de la Mano AM, Manso MA, Orfao A, de Dios I. Time-course of oxygen free radical production in acinar cells during acute pancreatitis induced by pancreatic duct obstruction. Biochim Biophys Acta 2002;1588:159-164.","DOI":"10.1016\/S0925-4439(02)00160-6"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Park BK, Chung JB, Lee JH, Suh JH, Park SW, Song SY, Kim H, Kim KH, Kang JK. Role of oxygen free radicals in patients with acute pancreatitis. World J Gastroenterol 2003;9:2266-2269.","DOI":"10.3748\/wjg.v9.i10.2266"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2004.00168.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2003.02937.x"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"G&oacute;mez-Cambronero L, Camps B, de La Asunci&oacute;n JG, Cerd&aacute; M, Pell&iacute;n A, Pallard&oacute; FV, Calvete J, Sweiry JH, Mann GE, Vi\u00f1a J. Pentoxifylline ameliorates cerulein-induced pancreatitis in rats: role of glutathione and nitric oxide. J Pharmacol Exp Ther 2000;293:670-676.","DOI":"10.1016\/S0022-3565(24)39283-3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026656720868"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"ref24","unstructured":"Luck H. Methods of enzymatic analysis. 2nd ed Verlag Chemie: Academic Press; 1963;885-888."},{"key":"ref25","unstructured":"Gruji\u0107 M, Rizvanbegovi\u0107 B, Perinovi\u0107 M, Perinovi\u0107 ID. [Glurenorm a new peroral antidiabetic agent belonging to the group of sulfonylurea compounds]. Med Arh 1976;30:119-121."},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00421-5"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(85)90192-0"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809090199"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Jungermann J, Lerch MM, Weidenbach H, Lutz MP, Kr&uuml;ger B, Adler G. Disassembly of rat pancreatic acinar cell cytoskeleton during supramaximal secretagogue stimulation. Am J Physiol 1995;268:G328-G338.","DOI":"10.1152\/ajpgi.1995.268.2.G328"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199207000-00011"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/BF02253360"},{"key":"ref33","unstructured":"Reiter RJ, Tan DX, Allegra M. Melatonin: reducing molecular pathology and dysfunction due to free radicals and associated reactants. Neuro Endocrinol Lett 2002;23 Suppl 1:3-8."},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1159\/000014635"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4709-9_48"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v12\/i2\/259.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T19:53:14Z","timestamp":1748807594000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v12\/i2\/259.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v12.i2.259","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]}}}