{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:26:25Z","timestamp":1768472785077,"version":"3.49.0"},"reference-count":56,"publisher":"Baishideng Publishing Group Inc.","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2014]]},"DOI":"10.3748\/wjg.v20.i29.10038","type":"journal-article","created":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T20:33:34Z","timestamp":1407702814000},"page":"10038","source":"Crossref","is-referenced-by-count":12,"title":["Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells"],"prefix":"10.3748","volume":"20","author":[{"given":"Matilde","family":"Spampatti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-12-0024"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2012.11.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1230"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0290-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.204453"},{"key":"ref6","unstructured":"Grozinsky-Glasberg S, Gross DJ. New drugs in the therapy of neuroendocrine tumors. J Endocrinol Invest 2012;35:930-936."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000336089"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2330-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8892"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/235040"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.05.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.2056"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Ugurlucan M, Caglar IM, Caglar FN, Ziyade S, Karatepe O, Yildiz Y, Zencirci E, Ugurlucan FG, Arslan AH, Korkmaz S. Aspirin: from a historical perspective. Recent Pat Cardiovasc Drug Discov 2012;7:71-76.","DOI":"10.2174\/157489012799362377"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-30331-9_3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2012.10.001"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.02.050"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.203000"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70112-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61720-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds113"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200609"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2123"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Zitzmann K, De Toni EN, Brand S, G&ouml;ke B, Meinecke J, Sp&ouml;ttl G, Meyer HH, Auernhammer CJ. The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells. Neuroendocrinology 2007;85:54-60.","DOI":"10.1159\/000100057"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Grozinsky-Glasberg S, Franchi G, Teng M, Leontiou CA, Ribeiro de Oliveira A, Dalino P, Salahuddin N, Korbonits M, Grossman AB. Octreotide and the mTOR inhibitor RAD001 (everolimus) block proliferation and interact with the Akt-mTOR-p70S6K pathway in a neuro-endocrine tumour cell Line. Neuroendocrinology 2008;87:168-181.","DOI":"10.1159\/000111501"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009290"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61742-X"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Evers BM, Townsend CM, Upp JR, Allen E, Hurlbut SC, Kim SW, Rajaraman S, Singh P, Reubi JC, Thompson JC. Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth. Gastroenterology 1991;101:303-311.","DOI":"10.1016\/0016-5085(91)90004-5"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"K&ouml;lby L, Bernhardt P, Ahlman H, W&auml;ngberg B, Johanson V, Wigander A, Forssell-Aronsson E, Karlsson S, Ahr&eacute;n B, Stenman G. A transplantable human carcinoid as model for somatostatin receptor-mediated and amine transporter-mediated radionuclide uptake. Am J Pathol 2001;158:745-755.","DOI":"10.1016\/S0002-9440(10)64017-5"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60243-9"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207756"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-12-0074"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32835c034f"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3797\/scipharm.1206-12"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Cerletti C, Dell&rsquo;Elba G, Manarini S, Pecce R, Di Castelnuovo A, Scorpiglione N, Feliziani V, de Gaetano G. Pharmacokinetic and pharmacodynamic differences between two low dosages of aspirin may affect therapeutic outcomes. Clin Pharmacokinet 2003;42:1059-1070.","DOI":"10.2165\/00003088-200342120-00004"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Kershaw RA, Mays DC, Bianchine JR, Gerber N. Disposition of aspirin and its metabolites in the semen of man. J Clin Pharmacol 1987;27:304-309.","DOI":"10.1002\/j.1552-4604.1987.tb03019.x"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2011.4.2222"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Ju&aacute;rez Olgu&iacute;n H, Flores P&eacute;rez J, Lares Asseff I, Loredo Abdal&aacute; A, Carbajal Rodr&iacute;guez L. Comparative pharmacokinetics of acetyl salicylic acid and its metabolites in children suffering from autoimmune diseases. Biopharm Drug Dispos 2004;25:1-7.","DOI":"10.1002\/bdd.379"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004;18:1926-1945.","DOI":"10.1101\/gad.1212704"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase\/akt pathway. Mol Cell 2002;10:151-162.","DOI":"10.1016\/S1097-2765(02)00568-3"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Nobukini T, Thomas G. The mTOR\/S6K signalling pathway: the role of the TSC1\/2 tumour suppressor complex and the proto-oncogene Rheb. Novartis Found Symp 2004;262:148-54; discussion 154-159, 265-268.","DOI":"10.1002\/0470869976.ch9"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080281"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.02.016"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26011"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.02.018"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0718"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2008.03.008"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Puri N, Salgia R. Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer. J Carcinog 2008;7:9.","DOI":"10.4103\/1477-3163.44372"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3898"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0262"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048208"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1159\/000335136"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Woodgett JR. Judging a protein by more than its name: GSK-3. Sci STKE 2001;2001:re12.","DOI":"10.1126\/scisignal.1002001re12"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2008.00085.x"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Shakoori A, Mai W, Miyashita K, Yasumoto K, Takahashi Y, Ooi A, Kawakami K, Minamoto T. Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents. Cancer Sci 2007;98:1388-1393.","DOI":"10.1111\/j.1349-7006.2007.00545.x"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol 2003;13:65-70.","DOI":"10.1016\/S0962-8924(02)00043-0"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2011.713"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i29\/10038.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T15:11:32Z","timestamp":1565709092000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i29\/10038.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":56,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v20.i29.10038","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}