{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:38:19Z","timestamp":1791905899854,"version":"4.3.4"},"reference-count":29,"publisher":"Baishideng Publishing Group Inc.","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2014]]},"DOI":"10.3748\/wjg.v20.i29.10158","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:33:34Z","timestamp":1407717214000},"page":"10158","source":"Crossref","is-referenced-by-count":72,"title":["Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats"],"prefix":"10.3748","volume":"20","author":[{"given":"Sami","family":"Akbulut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/987508"},{"key":"ref2","unstructured":"Soliman ME. Evaluation of the possible protective role of folic acid on the liver toxicity \u0131nduced experimentally by methotrexate in adult male albino rats. Egypt J Histol 2009;32:118-128."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/0960327112468178"},{"key":"ref4","unstructured":"Cetin A, Kaynar L, Eser B, Karada C, Saraymen B, &Ouml;zt&uuml;rk A. Beneficial effects of propolis on methotrexate-induced liver \u0131njury in rats. Acta Oncologica Turcica 2011;44:18-23."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310367806"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.99426"},{"key":"ref7","unstructured":"Cetinkaya A, Bulbuloglu E, Kurutas EB, Kantarceken B. N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Med Sci Monit 2006;12:BR274-BR278."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5152\/balkanmedj.2012.078"},{"key":"ref9","unstructured":"Stankiewicz A, Skrzydlewska E. Amifostine antioxidant effect on serum of rats treated with cyclophosphodamide. Polish J Environ Studies 2005;14:341-346."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2009.00400.x"},{"key":"ref11","unstructured":"Ray S, Roy K, Sengupta C. Exploring the protective effect of ascorbic acid and aqueous extract of spirulina platensis on methotrexate-induced lipid peroxidation. Iran J Pharm Sci 2007;3:217-228."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2298\/ABS0802169D"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043455567"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Tunali-Akbay T, Sehirli O, Ercan F, Sener G. Resveratrol protects against methotrexate-induced hepatic injury in rats. J Pharm Pharm Sci 2010;13:303-310.","DOI":"10.18433\/J30K5Q"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Babiak RM, Campello AP, Carnieri EG, Oliveira MB. Methotrexate: pentose cycle and oxidative stress. Cell Biochem Funct 1998;16:283-293.","DOI":"10.1002\/(SICI)1099-0844(1998120)16:4<283::AID-CBF801>3.0.CO;2-E"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410003605"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"ref19","unstructured":"Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-169."},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988;34:497-500.","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000052796"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.10.014"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"ref24","unstructured":"Hemeida RA, Mohafez OM. Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats. J Egypt Natl Canc Inst 2008;20:141-148."},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1071"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1080\/08860220500244823"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9949-3"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1830-4"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.883591"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i29\/10158.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T02:34:22Z","timestamp":1598150062000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i29\/10158.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":29,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v20.i29.10158","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}