{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:11:57Z","timestamp":1781604717032,"version":"3.54.5"},"reference-count":40,"publisher":"Baishideng Publishing Group Inc.","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2014]]},"DOI":"10.3748\/wjg.v20.i35.12367","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T11:04:03Z","timestamp":1411470243000},"page":"12367","source":"Crossref","is-referenced-by-count":11,"title":["Hepatitis C-associated liver carcinogenesis: Role of PML nuclear bodies"],"prefix":"10.3748","volume":"20","author":[{"given":"Kerstin","family":"Herzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1292890"},{"key":"ref2","unstructured":"Cicinnati VR, Sotiropoulos GC, Beckebaum S. Established and emerging therapies for hepatocellular carcinoma. Minerva Med 2010;101:405-418."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Moudgil V, Redhu D, Dhanda S, Singh J. A review of molecular mechanisms in the development of hepatocellular carcinoma by aflatoxin and hepatitis B and C viruses. J Environ Pathol Toxicol Oncol 2013;32:165-175.","DOI":"10.1615\/JEnvironPatholToxicolOncol.2013007166"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Teufel A, Staib F, Kanzler S, Weinmann A, Schulze-Bergkamen H, Galle PR. Genetics of hepatocellular carcinoma. World J Gastroenterol 2007;13:2271-2282.","DOI":"10.3748\/wjg.v13.i16.2271"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.05.035"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835e33bb"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2012.18.4.347"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12393"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-013-1780-x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00943.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2831"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21740"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S41127"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401313"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/3073"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Gurrieri C, Capodieci P, Bernardi R, Scaglioni PP, Nafa K, Rush LJ, Verbel DA, Cordon-Cardo C, Pandolfi PP. Loss of the tumor suppressor PML in human cancers of multiple histologic origins. J Natl Cancer Inst 2004;96:269-279.","DOI":"10.1093\/jnci\/djh043"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.11.005"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911402682"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/path.4195"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-226639"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.07.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.043232"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2430"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.01.002"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(04)63002-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v4.i12.342"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2012.01.006"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"You LR, Chen CM, Lee YH. Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha. J Virol 1999;73:1672-1681.","DOI":"10.1128\/JVI.73.2.1672-1681.1999"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.9.4372-4379.2006"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0880"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Kao CF, Chen SY, Chen JY, Wu Lee YH. Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein. Oncogene 2004;23:2472-2483.","DOI":"10.1038\/sj.onc.1207368"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Otsuka M, Kato N, Lan K, Yoshida H, Kato J, Goto T, Shiratori Y, Omata M. Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability. J Biol Chem 2000;275:34122-34130.","DOI":"10.1074\/jbc.M000578200"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Honda M, Kaneko S, Shimazaki T, Matsushita E, Kobayashi K, Ping LH, Zhang HC, Lemon SM. Hepatitis C virus core protein induces apoptosis and impairs cell-cycle regulation in stably transformed Chinese hamster ovary cells. Hepatology 2000;31:1351-1359.","DOI":"10.1053\/jhep.2000.7985"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Ray RB, Meyer K, Ray R. Suppression of apoptotic cell death by hepatitis C virus core protein. Virology 1996;226:176-182.","DOI":"10.1006\/viro.1996.0644"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Ray RB, Steele R, Meyer K, Ray R. Transcriptional repression of p53 promoter by hepatitis C virus core protein. J Biol Chem 1997;272:10983-10986.","DOI":"10.1074\/jbc.272.17.10983"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Disson O, Haouzi D, Desagher S, Loesch K, Hahne M, Kremer EJ, Jacquet C, Lemon SM, Hibner U, Lerat H. Impaired clearance of virus-infected hepatocytes in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 2004;126:859-872.","DOI":"10.1053\/j.gastro.2003.12.005"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044474"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.63"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62129"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Chan JY, Chin W, Liew CT, Chang KS, Johnson PJ. Altered expression of the growth and transformation suppressor PML gene in human hepatocellular carcinomas and in hepatitis tissues. Eur J Cancer 1998;34:1015-1022.","DOI":"10.1016\/S0959-8049(97)10138-1"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i35\/12367.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T20:36:24Z","timestamp":1598301384000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i35\/12367.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":40,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v20.i35.12367","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}