{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:59:10Z","timestamp":1784807950595,"version":"3.55.0"},"reference-count":82,"publisher":"Baishideng Publishing Group Inc.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2014]]},"DOI":"10.3748\/wjg.v20.i43.16037","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T11:17:23Z","timestamp":1457781443000},"page":"16037","source":"Crossref","is-referenced-by-count":29,"title":["Potent antiviral therapy improves survival in acute on chronic liver failure due to hepatitis B virus reactivation"],"prefix":"10.3748","volume":"20","author":[{"given":"Cyriac Abby","family":"Philips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","unstructured":"Ohnishi H, Sugihara J, Moriwaki H, Muto Y. [Acute-on-chronic liver failure]. Ryoikibetsu Shokogun Shirizu 1995;217-219."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9106-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24622"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e328344b446"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20236"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.017"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.06.013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05243.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02842.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.10.019"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07451.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/00365540701522975"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1590"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Zhu CL, Yan WM, Zhu F, Zhu YF, Xi D, Tian DY, Levy G, Luo XP, Ning Q. Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B. World J Gastroenterol 2005;11:6936-6940.","DOI":"10.3748\/wjg.v11.i44.6936"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2011.08.029"},{"key":"ref16","unstructured":"Inoue T, Fuke H, Yamamoto N, Ito K, Yutaka KY, Yamanaka K. Lamivudine for treatment of spontaneous exacerbation and reactivation after immunosuppressive therapy in patients with hepatitis B virus infection. Hepatogastroenterology 2007;54:889-891."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22106"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/cc10424"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1086\/376988"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1630"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20661"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Liaw YF, Yang SS, Chen TJ, Chu CM. Acute exacerbation in hepatitis B e antigen positive chronic type B hepatitis. A clinicopathological study. J Hepatol 1985;1:227-233.","DOI":"10.1016\/S0168-8278(85)80050-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-1-43"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Lok AS, Lai CL. Acute exacerbations in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology. J Hepatol 1990;10:29-34.","DOI":"10.1016\/0168-8278(90)90069-4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05924.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i24.7644"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Brunetto MR, Giarin MM, Oliveri F, Chiaberge E, Baldi M, Alfarano A, Serra A, Saracco G, Verme G, Will H. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci USA 1991;88:4186-4190.","DOI":"10.1073\/pnas.88.10.4186"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1007-3418.2012.07.009"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Milich DR, Jones JE, Hughes JL, Price J, Raney AK, McLachlan A. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc Natl Acad Sci USA 1990;87:6599-6603.","DOI":"10.1073\/pnas.87.17.6599"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Chu CM, Liaw YF, Pao CC, Huang MJ. The etiology of acute hepatitis superimposed upon previously unrecognized asymptomatic HBsAg carriers. Hepatology 1989;9:452-456.","DOI":"10.1002\/hep.1840090319"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Inoue K, Yoshiba M, Sekiyama K, Okamoto H, Mayumi M. Clinical and molecular virological differences between fulminant hepatic failures following acute and chronic infection with hepatitis B virus. J Med Virol 1998;55:35-41.","DOI":"10.1002\/(SICI)1096-9071(199805)55:1<35::AID-JMV7>3.0.CO;2-P"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115590"},{"key":"ref33","unstructured":"Yang PM, Su IJ, Lai MY, Huang GT, Hsu HC, Chen DS, Sung JL. Immunohistochemical studies on intrahepatic lymphocyte infiltrates in chronic type B hepatitis, with special emphasis on the activation status of the lymphocytes. Am J Gastroenterol 1988;83:948-953."},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Lok AS, Lai CL, Wu PC, Leung EK, Lam TS. Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infection. Gastroenterology 1987;92:1839-1843.","DOI":"10.1016\/0016-5085(87)90613-5"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-10-201205150-00013"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Maruyama T, Iino S, Koike K, Yasuda K, Milich DR. Serology of acute exacerbation in chronic hepatitis B virus infection. Gastroenterology 1993;105:1141-1151.","DOI":"10.1016\/0016-5085(93)90960-K"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Gerlich WH, Uy A, Lambrecht F, Thomssen R. Cutoff levels of immunoglobulin M antibody against viral core antigen for differentiation of acute, chronic, and past hepatitis B virus infections. J Clin Microbiol 1986;24:288-293.","DOI":"10.1128\/JCM.24.2.288-293.1986"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-3175-2"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05391.x"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2002.00385.x"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.02.023"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05484.x"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2010.01295.x"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i29.3448"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2004.03534.x"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20055"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Wong VW, Wong GL, Tsang SW, Hui AY, Chim AM, Yiu KK, Chan HY, Chan FK, Sung JJ, Chan HL. Long-term follow-up of lamivudine treatment in patients with severe acute exacerbation of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B. Antivir Ther 2008;13:571-579.","DOI":"10.1177\/135965350801300407"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-011-0160-7"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00419-1"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06089.x"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Thabut D, Ratziu V, Bernard-Chabert B, Poynard T, Benhamou Y, Thibault V. Unsuccessful rescue therapy with adefovir dipivoxil for lamivudine resistant HBV in a patient with liver failure. Gut 2003;52:614.","DOI":"10.1136\/gut.52.4.614-a"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-812683"},{"key":"ref53","unstructured":"Chen J, Han JH, Liu C, Yu RH, Li FZ, Li QF, Gong GZ. Short-term entecavir therapy of chronic severe hepatitis B. Hepatobiliary Pancreat Dis Int 2009;8:261-266."},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(13)60025-9"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.850"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.043"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23346"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1257-7"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-349"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.02.013"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.03.004"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24109"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054773"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Yu S, Jianqin H, Wei W, Jianrong H, Yida Y, Jifang S, Liang Y, Zhi C, Hongyu J. The efficacy and safety of nucleos(t)ide analogues in the treatment of HBV-related acute-on-chronic liver failure: a meta-analysis. Ann Hepatol 2013;12:364-372.","DOI":"10.1016\/S1665-2681(19)30998-6"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i36.5078"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.6415"},{"key":"ref67","unstructured":"He WP, Hu JH, Zhao J, Tong JJ, Ding JB, Lin F, Wang HF. Comparison of four prognostic models and a new Logistic regression model to predict short-term prognosis of acute-on-chronic hepatitis B liver failure. Chin Med J (Engl) 2012;125:2272-2278."},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.08.006"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22317"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.11.027"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i7.1104"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00740.x"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-009-9148-8"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31822e6eda"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.5754\/hge10148"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23401"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23678"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.03.008"},{"key":"ref79","unstructured":"Yang H, Wang Y, Jiang N. Baraclude for treatment of 55 patients with chronic severe hepatitis B. J Practical Medical Technology 2008;15:1100-1101."},{"key":"ref80","unstructured":"Qiu S, Li W, Peng Q Short-term observation of telbivudine in treatment of chronic severe hepatitis B. Chin J Clini Hepatol 2009;25:190-191."},{"key":"ref81","unstructured":"Qin R, Zhu S, Wang G, Den J. Analysis of therapeutic effect of telbivudine on severe chronic hepatitis B. Modern Hospital 2012;12:55-57."},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12454"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i43\/16037.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T01:28:03Z","timestamp":1655256483000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i43\/16037.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":82,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v20.i43.16037","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}