{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:39:59Z","timestamp":1768477199974,"version":"3.49.0"},"reference-count":72,"publisher":"Baishideng Publishing Group Inc.","issue":"48","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2014]]},"DOI":"10.3748\/wjg.v20.i48.18121","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T03:18:25Z","timestamp":1420427905000},"page":"18121","source":"Crossref","is-referenced-by-count":102,"title":["Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes"],"prefix":"10.3748","volume":"20","author":[{"given":"Giovanni","family":"Tomasello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Hajj Hussein IA, Tohme R, Barada K, Mostafa MH, Freund JN, Jurjus RA, Karam W, Jurjus A. Inflammatory bowel disease in rats: bacterial and chemical interaction. World J Gastroenterol 2008;14:4028-4039.","DOI":"10.3748\/wjg.14.4028"},{"key":"ref2","unstructured":"Margiotta G, Sanfilippo A, Accardo FM, Damiani P, Geraci A, Tomasello G. Chronic Inflammatory Bowel Disease in patients with orthopedic manifestation. Comparison with the data reported in international literauture. Euromediterranean Biomedical J 2012;7:33-38."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X12473674"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020447"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-013-0346-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MRM.0b013e328353f49c"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Bettelheim KA, Breadon A, Faiers MC, O&rsquo;Farrell SM, Shooter RA. The origin of O serotypes of Escherichia coli in babies after normal delivery. J Hyg (Lond) 1974;72:67-70.","DOI":"10.1017\/S0022172400023226"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.14"},{"key":"ref10","unstructured":"Tralongo P, Tomasello G, Sinagra E; Damiani P, Leone A, Palumbo VD, Giammanco M, Di Majo D, Damiani F, Abruzzo A, Bruno A. The role of butyric acid as a protective agent against Inflammatory Bowel Diseases. Euro Biomed J 2014;9:24-35."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.152"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.12.100"},{"key":"ref13","unstructured":"Trubitsyna IE, Drozdov VN, Baryshnikov EN, Chikunova BZ, Petrakov AV. [The damaging role of endogenous nitric oxide in the development of the experimental DSS-induced colitis in rats]. Eksp Klin Gastroenterol 2010;74-77."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.08.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20736"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.05.014"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005641"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0352-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0684-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080235"},{"key":"ref21","unstructured":"Gallan L. Dysbiotic relationships in the bowel. American College of Advancement in Medicine Conference; Spring 1992;."},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Mitsuoka T. Intestinal Flora and aging. Nutr Rev 1992;50:438-446.","DOI":"10.1111\/j.1753-4887.1992.tb02499.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222669110"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016393"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.109"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"ref27","unstructured":"Rowe WA, Lichtenstein GR, Katz J. Inflammatory Bowel Disease. Medscape Drugs, Diseases and Procedures 2014; Available from: <ext-link ext-link-type=\"uri\" xlink:href=\"http:\/\/emedicine.medscape.com\/article\/179037-overview\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\">http:\/\/emedicine.medscape.com\/article\/179037-overview<\/ext-link>."},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/ng.145"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4614"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.318"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Maggio M, Guralnik JM, Longo DL, Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci 2006;61:575-584.","DOI":"10.1093\/gerona\/61.6.575"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3390\/nu4081095"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181dlblle"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2009"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.02.015"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3180406a11"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.43"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1101\/gr.126516.111"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1101\/gr.126573.111"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.104380"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Korzenik JR. Is Crohn&rsquo;s disease due to defective immunity? Gut 2007;56:2-5.","DOI":"10.1136\/gut.2006.095588"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241165"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Monteleone G, Biancone L, Marasco R, Morrone G, Marasco O, Luzza F, Pallone F. Interleukin 12 is expressed and actively released by Crohn&rsquo;s disease intestinal lamina propria mononuclear cells. Gastroenterology 1997;112:1169-1178.","DOI":"10.1016\/S0016-5085(97)70128-8"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Pizarro TT, Michie MH, Bentz M, Woraratanadharm J, Smith MF, Foley E, Moskaluk CA, Bickston SJ, Cominelli F. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn&rsquo;s disease: expression and localization in intestinal mucosal cells. J Immunol 1999;162:6829-6835.","DOI":"10.4049\/jimmunol.162.11.6829"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Bamias G, Martin C, Mishina M, Ross WG, Rivera-Nieves J, Marini M, Cominelli F. Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation. Gastroenterology 2005;128:654-666.","DOI":"10.1053\/j.gastro.2004.11.053"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.06.001"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00180"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2015"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2012.35"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7823"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804288"},{"key":"ref54","unstructured":"Macario AJL, Conway de Macario E. The chaperoning system: physiology and pathology. Experimental Medicine Reviews Anguilla: Plumelia, 2008\/; 2009;9-21 (ISBN 978-88-89876-15-2)."},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Macario AJ, Lange M, Ahring BK, Conway de Macario E. Stress genes and proteins in the archaea. Microbiol Mol Biol Rev 1999;63:923-67, table of contents.","DOI":"10.1128\/MMBR.63.4.923-967.1999"},{"key":"ref56","unstructured":"Rappa F, Farina F, Zummo G, David S, Campanella C, Carini F, Tomasello G, Damiani P, Cappello F, DE Macario EC. HSP-molecular chaperones in cancer biogenesis and tumor therapy: an overview. Anticancer Res 2012;32:5139-5150."},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"van Eden W, Thole JE, van der Zee R, Noordzij A, van Embden JD, Hensen EJ, Cohen IR. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 1988;331:171-173.","DOI":"10.1038\/331171a0"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 2001;358:1749-1753.","DOI":"10.1016\/S0140-6736(01)06801-5"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Maron R, Sukhova G, Faria AM, Hoffmann E, Mach F, Libby P, Weiner HL. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 2002;106:1708-1715.","DOI":"10.1161\/01.CIR.0000029750.99462.30"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Rha YH, Taube C, Haczku A, Joetham A, Takeda K, Duez C, Siegel M, Aydintug MK, Born WK, Dakhama A. Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. J Immunol 2002;169:5300-5307.","DOI":"10.4049\/jimmunol.169.9.5300"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000552"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2011.e38"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"W&auml;chtersh&auml;user A, Stein J. Rationale for the luminal provision of butyrate in intestinal diseases. Eur J Nutr 2000;39:164-171.","DOI":"10.1007\/s003940070020"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Zoran DL, Barhoumi R, Burghardt RC, Chapkin RS, Lupton JR. Diet and carcinogen alter luminal butyrate concentration and intracellular pH in isolated rat colonocytes. Nutr Cancer 1997;27:222-230.","DOI":"10.1080\/01635589709514530"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Basson MD, Liu YW, Hanly AM, Emenaker NJ, Shenoy SG, Gould Rothberg BE. Identification and comparative analysis of human colonocyte short-chain fatty acid response genes. J Gastrointest Surg 2000;4:501-512.","DOI":"10.1016\/S1091-255X(00)80093-1"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Myzak MC, Dashwood RH. Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. Curr Drug Targets 2006;7:443-452.","DOI":"10.2174\/138945006776359467"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Davie JR. Inhibition of histone deacetylase activity by butyrate. J Nutr 2003;133:2485S-2493S.","DOI":"10.1093\/jn\/133.7.2485S"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v23i0.17195"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Huycke MM, Gaskins HR. Commensal bacteria, redox stress, and colorectal cancer: mechanisms and models. Exp Biol Med (Maywood) 2004;229:586-597.","DOI":"10.1177\/153537020422900702"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224820"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28853"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821d298f"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i48\/18121.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:25:56Z","timestamp":1690799156000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v20\/i48\/18121.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":72,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v20.i48.18121","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}