{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:32:21Z","timestamp":1770564741284,"version":"3.49.0"},"reference-count":29,"publisher":"Baishideng Publishing Group Inc.","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2015]]},"DOI":"10.3748\/wjg.v21.i10.3100","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T01:16:46Z","timestamp":1426468606000},"page":"3100","source":"Crossref","is-referenced-by-count":48,"title":["Nonselective beta-blockers in cirrhotic patients with no or small varices: A meta-analysis"],"prefix":"10.3748","volume":"21","author":[{"given":"Xing-Shun","family":"Qi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901512"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007133"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Pagliaro L, D&rsquo;Amico G, S&ouml;rensen TI, Lebrec D, Burroughs AK, Morabito A, Tin&eacute; F, Politi F, Traina M. Prevention of first bleeding in cirrhosis. A meta-analysis of randomized trials of nonsurgical treatment. Ann Intern Med 1992;117:59-70.","DOI":"10.7326\/0003-4819-117-1-59"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710013171403"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105303242202"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Id&eacute;o G, Bellati G, Fesce E, Grimoldi D. Nadolol can prevent the first gastrointestinal bleeding in cirrhotics: a prospective, randomized study. Hepatology 1988;8:6-9.","DOI":"10.1002\/hep.1840080103"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112033052302"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21907"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9096-8"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Andreani T, Poupon RE, Balkau BJ, Trinchet JC, Grange JD, Peigney N, Beaugrand M, Poupon R. Preventive therapy of first gastrointestinal bleeding in patients with cirrhosis: results of a controlled trial comparing propranolol, endoscopic sclerotherapy and placebo. Hepatology 1990;12:1413-1419.","DOI":"10.1002\/hep.1840120624"},{"key":"ref12","unstructured":"Cal&eacute;s P, Oberti F, Payen JL, Naveau S, Guyader D, Blanc P, Abergel A, Bichard P, Raymond JM, Canva-Delcambre V. Lack of effect of propranolol in the prevention of large oesophageal varices in patients with cirrhosis: a randomized trial. French-Speaking Club for the Study of Portal Hypertension. Eur J Gastroenterol Hepatol 1999;11:741-745."},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Groszmann RJ, Garcia-Tsao G, Bosch J, Grace ND, Burroughs AK, Planas R, Escorsell A, Garcia-Pagan JC, Patch D, Matloff DS. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 2005;353:2254-2261.","DOI":"10.1056\/NEJMoa044456"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Merkel C, Marin R, Angeli P, Zanella P, Felder M, Bernardinello E, Cavallarin G, Bolognesi M, Donada C, Bellini B. A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis. Gastroenterology 2004;127:476-484.","DOI":"10.1053\/j.gastro.2004.05.004"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Sarin SK, Mishra SR, Sharma P, Sharma BC, Kumar A. Early primary prophylaxis with beta-blockers does not prevent the growth of small esophageal varices in cirrhosis: A randomized controlled trial. Hepatol Int 2013;7:248-256.","DOI":"10.1007\/s12072-012-9353-8"},{"key":"ref16","unstructured":"Conn HO, Grace ND, Bosch J, Groszmann RJ, Rod&eacute;s J, Wright SC, Matloff DS, Garcia-Tsao G, Fisher RL, Navasa M. Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial. The Boston-New Haven-Barcelona Portal Hypertension Study Group. Hepatology 1991;13:902-912."},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Abraczinskas DR, Ookubo R, Grace ND, Groszmann RJ, Bosch J, Garcia-Tsao G, Richardson CR, Matloff DS, Rod&eacute;s J, Conn HO. Propranolol for the prevention of first esophageal variceal hemorrhage: a lifetime commitment? Hepatology 2001;34:1096-1102.","DOI":"10.1053\/jhep.2001.29305"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Merli M, Nicolini G, Angeloni S, Rinaldi V, De Santis A, Merkel C, Attili AF, Riggio O. Incidence and natural history of small esophageal varices in cirrhotic patients. J Hepatol 2003;38:266-272.","DOI":"10.1016\/S0168-8278(02)00420-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810133191505"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.024"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.01.014"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02038.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2013.08.026"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23775"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.034"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i32.11463"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(81)73224-3"},{"key":"ref28","unstructured":"Conn HO. Ammonia tolerance in the diagnosis of esophageal varices. A comparison of endoscopic, radiologic, and biochemical techniques. J Lab Clin Med 1967;70:442-451."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(92)90044-P"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i10\/3100.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:57:20Z","timestamp":1566435440000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i10\/3100.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v21.i10.3100","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}