{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:14:07Z","timestamp":1791252847832,"version":"4.1.0"},"reference-count":103,"publisher":"Baishideng Publishing Group Inc.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2015]]},"DOI":"10.3748\/wjg.v21.i12.3462","type":"journal-article","created":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T03:55:49Z","timestamp":1427687749000},"page":"3462","source":"Crossref","is-referenced-by-count":108,"title":["Management of hepatocellular carcinoma with portal vein thrombosis"],"prefix":"10.3748","volume":"21","author":[{"given":"Matthew","family":"Quirk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61347-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.100"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/J.Gastro.2010.09.038"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04724.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws448"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.061"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03029.x"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Minagawa M, Makuuchi M. Treatment of hepatocellular carcinoma accompanied by portal vein tumor thrombus. World J Gastroenterol 2006;12:7561-7567.","DOI":"10.3748\/wjg.v12.i47.7561"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290145"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Pirisi M, Avellini C, Fabris C, Scott C, Bardus P, Soardo G, Beltrami CA, Bartoli E. Portal vein thrombosis in hepatocellular carcinoma: age and sex distribution in an autopsy study. J Cancer Res Clin Oncol 1998;124:397-400.","DOI":"10.1007\/s004320050189"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Sch&ouml;niger-Hekele M, M&uuml;ller C, Kutilek M, Oesterreicher C, Ferenci P, Gangl A. Hepatocellular carcinoma in Central Europe: prognostic features and survival. Gut 2001;48:103-109.","DOI":"10.1136\/gut.48.1.103"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000348325"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000109146.72827.76"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000109022.32391.eb"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Shimada M, Takenaka K, Gion T, Fujiwara Y, Kajiyama K, Maeda T, Shirabe K, Nishizaki T, Yanaga K, Sugimachi K. Prognosis of recurrent hepatocellular carcinoma: a 10-year surgical experience in Japan. Gastroenterology 1996;111:720-726.","DOI":"10.1053\/gast.1996.v111.pm8780578"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0940-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.08.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3074-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.12.012"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0868-x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2005.12.011"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247133"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-010-9165-7"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280322"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.06.014"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.12.006"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24029"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283386053"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/Meg.0b013e328333df23"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0547"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/791013"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.6.696"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08649-X"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50047"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33156"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111550"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1148\/Radiol.10101058"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Lee HS, Kim JS, Choi IJ, Chung JW, Park JH, Kim CY. The safety and efficacy of transcatheter arterial chemoembolization in the treatment of patients with hepatocellular carcinoma and main portal vein obstruction. A prospective controlled study. Cancer 1997;79:2087-2094.","DOI":"10.1002\/(SICI)1097-0142(19970601)79:11<2087::AID-CNCR5>3.0.CO;2-M"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1321-8"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1007\/S12032-011-0145-0"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05728.x"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2014.391"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1111\/ans.12803"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-60"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00418-K"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2005.04.005"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Hoffe SE, Finkelstein SE, Russell MS, Shridhar R. Nonsurgical options for hepatocellular carcinoma: evolving role of external beam radiotherapy. Cancer Control 2010;17:100-110.","DOI":"10.1177\/107327481001700205"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1159\/000345893"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.07.005"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2014.32.3.170"},{"key":"ref55","unstructured":"Sugiyama S, Beppu T, Ishiko T, Takahashi M, Masuda T, Hirata T, Imai K, Hayashi H, Takamori H, Kanemitsu K. Efficacy of radiotherapy for PV and IVC tumor thrombosis in unresectable HCC. Hepatogastroenterology 2007;54:1779-1782."},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.12.024"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.8.1014"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.2165\/0044011-200929010-00007"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.01.017"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-1993-9"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12445"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12207"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2013.196"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230x-14-84"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-005-0171-4"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.09.004"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.012"},{"key":"ref68","unstructured":"D&rsquo;Avola D, L\u00f1arrairaegui M, Bilbao JI, Martinez-Cuesta A, Alegre F, Herrero JI, Quiroga J, Prieto J, Sangro B. A retrospective comparative analysis of the effect of Y90-radioembolization on the survival of patients with unresectable hepatocellular carcinoma. Hepatogastroenterology 2009;56:1683-1688."},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23944"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1053\/J.Gastro.2009.09.006"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24451"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2010.04.012"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21980"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/827649"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1097\/01.Rvi.0000123319.20705.92"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26014"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2304-3881.2014.07.09"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181ec61bb"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.11.050"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/J.Ijrobp.2006.11.060"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.001"},{"key":"ref82","unstructured":"National Comprehensive Cancer Network. Hepatobiliary Cancers. NCCN Clinical Practice Guidelines in Oncology 2015;Version 2.2015:HCC-1-HCC-C."},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Chevret S, Trinchet JC, Mathieu D, Rached AA, Beaugrand M, Chastang C. A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. Groupe d&rsquo;Etude et de Traitement du Carcinome H&eacute;patocellulaire. J Hepatol 1999;31:133-141.","DOI":"10.1016\/S0168-8278(99)80173-1"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1007\/s005350300038"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Leung TW, Tang AM, Zee B, Lau WY, Lai PB, Leung KL, Lau JT, Yu SC, Johnson PJ. Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients. Cancer 2002;94:1760-1769.","DOI":"10.1002\/cncr.10384"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007122"},{"key":"ref87","doi-asserted-by":"crossref","unstructured":"Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, Nakajima Y, Ohnishi K. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 1985;56:918-928.","DOI":"10.1002\/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.032"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2013.01.494"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.05.007"},{"key":"ref91","doi-asserted-by":"crossref","unstructured":"Lencioni R, Llovet JM, Han G, Tak WY, Yang J, Leberre MA, Niu W, Nicholson K, Meinhardt G, Brui J. Sorafenib or placebo in combination with transarterial chemoembolization (TACE) with doxorubicin-eluting beads (DEBDOX) for intermediate-stage hepatocellular carcinoma (HCC): phase II, randomized, double-blind SPACE trial (abstr.). J Clin Oncol 2012;30:Abstr LBA154.","DOI":"10.1200\/jco.2012.30.4_suppl.lba154"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0313"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.01.006"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04697.x"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.1021"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2368-z"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt072"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14131946"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27925"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090909"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1016\/J.Jhep.2012.09.003"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2012.02940.x"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12352"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i12\/3462.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T12:27:04Z","timestamp":1566476824000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i12\/3462.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":103,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v21.i12.3462","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}