{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:08:41Z","timestamp":1791227321811,"version":"4.1.0"},"reference-count":113,"publisher":"Baishideng Publishing Group Inc.","issue":"28","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2015]]},"DOI":"10.3748\/wjg.v21.i28.8478","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T03:24:30Z","timestamp":1438226670000},"page":"8478","source":"Crossref","is-referenced-by-count":145,"title":["Current and future treatments for hepatocellular carcinoma"],"prefix":"10.3748","volume":"21","author":[{"given":"Alexander","family":"Schlachterman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1300\/J077v25n03_02"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1934"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02932.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603143341104"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24563"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000106911"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21281"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000259015.46798.ec"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.34923"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21329"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21334"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181814de2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.23311"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Bismuth H, Majno PE. Hepatobiliary surgery. J Hepatol 2000;32:208-224.","DOI":"10.1016\/S0168-8278(00)80427-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14964-1"},{"key":"ref16","unstructured":"Makuuchi M, Hasegawa H, Yamazaki S, Takayasu K. Four new hepatectomy procedures for resection of the right hepatic vein and preservation of the inferior right hepatic vein. Surg Gynecol Obstet 1987;164:68-72."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.12.003"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Man K, Fan ST, Ng IO, Lo CM, Liu CL, Wong J. Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized study. Ann Surg 1997;226:704-11; discussion 711-3.","DOI":"10.1097\/00000658-199712000-00007"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Belghiti J, Noun R, Zante E, Ballet T, Sauvanet A. Portal triad clamping or hepatic vascular exclusion for major liver resection. A controlled study. Ann Surg 1996;224:155-161.","DOI":"10.1097\/00000658-199608000-00007"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000098620.27623.7d"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300629"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Yeh CN, Lee WC, Chen MF, Tsay PK. Predictors of long-term disease-free survival after resection of hepatocellular carcinoma: two decades of experience at Chang Gung Memorial Hospital. Ann Surg Oncol 2003;10:916-921.","DOI":"10.1245\/ASO.2003.09.012"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000094549.11754.e6"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Poon RT, Ng IO, Fan ST, Lai EC, Lo CM, Liu CL, Wong J. Clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma: a study of a prospective cohort. J Clin Oncol 2001;19:3037-3044.","DOI":"10.1200\/JCO.2001.19.12.3037"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181961c16"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3892\/etm_00000076"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Jianyong L, Jinjing Z, Wentao W, Lunan Y, Qiao Z, Bo L, Tianfu W, Minqing X, Jiaying Y, Yongang W. Preoperative transcatheter arterial chemoembolization for resectable hepatocellular carcinoma: a single center analysis. Ann Hepatol 2014;13:394-402.","DOI":"10.1016\/S1665-2681(19)30846-4"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05709.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000201480.65519.b8"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701885481"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2281020718"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Shiina S, Teratani T, Obi S, Sato S, Tateishi R, Fujishima T, Ishikawa T, Koike Y, Yoshida H, Kawabe T. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology 2005;129:122-130.","DOI":"10.1053\/j.gastro.2005.04.009"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.20456"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.05.018"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0392-8"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0553-4"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00696.x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.001"},{"key":"ref40","unstructured":"Breedis C, Young G. The blood supply of neoplasms in the liver. Am J Pathol 1954;30:969-977."},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-006-0062-3"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Kan Z, McCuskey PA, Wright KC, Wallace S. Role of Kupffer cells in iodized oil embolization. Invest Radiol 1994;29:990-993.","DOI":"10.1097\/00004424-199411000-00007"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(02)08649-x"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33156"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50047"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Berger DH, Carrasco CH, Hohn DC, Curley SA. Hepatic artery chemoembolization or embolization for primary and metastatic liver tumors: post-treatment management and complications. J Surg Oncol 1995;60:116-121.","DOI":"10.1002\/jso.2930600210"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-009-9711-7"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12450"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-941442"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1258\/shorts.2009.090352"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.198.1.8539401"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Leung DA, Goin JE, Sickles C, Raskay BJ, Soulen MC. Determinants of postembolization syndrome after hepatic chemoembolization. J Vasc Interv Radiol 2001;12:321-326.","DOI":"10.1016\/S1051-0443(07)61911-3"},{"key":"ref53","unstructured":"Kobayashi S, Nakanuma Y, Terada T, Matsui O. Postmortem survey of bile duct necrosis and biloma in hepatocellular carcinoma after transcatheter arterial chemoembolization therapy: relevance to microvascular damages of peribiliary capillary plexus. Am J Gastroenterol 1993;88:1410-1415."},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Kim W, Clark TW, Baum RA, Soulen MC. Risk factors for liver abscess formation after hepatic chemoembolization. J Vasc Interv Radiol 2001;12:965-968.","DOI":"10.1016\/S1051-0443(07)61577-2"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23676"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1443"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-006-0393-4"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1377"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.11.060"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-9-86"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090095"},{"key":"ref64","unstructured":"Ackerman NB, Lien WM, Kondi ES, Silverman NA. The blood supply of experimental liver metastases. I. The distribution of hepatic artery and portal vein blood to &ldquo;small&rdquo; and &ldquo;large&rdquo; tumors. Surgery 1969;66:1067-1072."},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9727-7"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.05.065"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.075861"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Lau WY, Leung WT, Ho S, Leung NW, Chan M, Lin J, Metreweli C, Johnson P, Li AK. Treatment of inoperable hepatocellular carcinoma with intrahepatic arterial yttrium-90 microspheres: a phase I and II study. Br J Cancer 1994;70:994-999.","DOI":"10.1038\/bjc.1994.436"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1159\/000218349"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2010.04.027"},{"key":"ref71","unstructured":"Chiesa C, Maccauro M, Romito R, Spreafico C, Pellizzari S, Negri A, Sposito C, Morosi C, Civelli E, Lanocita R. Need, feasibility and convenience of dosimetric treatment planning in liver selective internal radiation therapy with (90)Y microspheres: the experience of the National Tumor Institute of Milan. Q J Nucl Med Mol Imaging 2011;55:168-197."},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Geschwind JF, Salem R, Carr BI, Soulen MC, Thurston KG, Goin KA, Van Buskirk M, Roberts CA, Goin JE. Yttrium-90 microspheres for the treatment of hepatocellular carcinoma. Gastroenterology 2004;127:S194-S205.","DOI":"10.1053\/j.gastro.2004.09.034"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.39627"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Salem R, Lewandowski R, Roberts C, Goin J, Thurston K, Abouljoud M, Courtney A. Use of Yttrium-90 glass microspheres (TheraSphere) for the treatment of unresectable hepatocellular carcinoma in patients with portal vein thrombosis. J Vasc Interv Radiol 2004;15:335-345.","DOI":"10.1097\/01.RVI.0000123319.20705.92"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290145"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.12.030"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2011.05.002"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE, Shank B, Solin LJ, Wesson M. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991;21:109-122.","DOI":"10.1016\/0360-3016(91)90171-Y"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Cheng JC, Wu JK, Huang CM, Liu HS, Huang DY, Tsai SY, Cheng SH, Jian JJ, Huang AT. Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease. Int J Radiat Oncol Biol Phys 2003;56:229-234.","DOI":"10.1016\/S0360-3016(03)00091-9"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Fuss M, Salter BJ, Herman TS, Thomas CR. External beam radiation therapy for hepatocellular carcinoma: potential of intensity-modulated and image-guided radiation therapy. Gastroenterology 2004;127:S206-S217.","DOI":"10.1053\/j.gastro.2004.09.035"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.02.047"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-6-76"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2006.24.705"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Suit H, Urie M. Proton beams in radiation therapy. J Natl Cancer Inst 1992;84:155-164.","DOI":"10.1093\/jnci\/84.3.155"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Okumura T, Itai Y, Tsuji H, Matsueda K, Matsuzaki Y, Tsujii H. Focused radiation hepatitis after Bragg-peak proton therapy for hepatocellular carcinoma: CT findings. J Comput Assist Tomogr 1994;18:821-823.","DOI":"10.1097\/00004728-199409000-00025"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1350"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21237"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-67"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.01.032"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Wilson JW, Reginatto M, Hajnal F, Chun SY. Calculation of dose, dose equivalent, and relative biological effectiveness for high charge and energy ion beams. Health Phys 1995;68:532-538.","DOI":"10.1097\/00004032-199504000-00010"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(10)60515-4"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.01.006"},{"key":"ref93","doi-asserted-by":"crossref","unstructured":"Torimura T, Sata M, Ueno T, Kin M, Tsuji R, Suzaku K, Hashimoto O, Sugawara H, Tanikawa K. Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma. Hum Pathol 1998;29:986-991.","DOI":"10.1016\/S0046-8177(98)90205-2"},{"key":"ref94","doi-asserted-by":"crossref","unstructured":"Conway EM, Collen D, Carmeliet P. Molecular mechanisms of blood vessel growth. Cardiovasc Res 2001;49:507-521.","DOI":"10.1016\/S0008-6363(00)00281-9"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.03.034"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960171"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209556"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.08.008"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32832962a1"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205591"},{"key":"ref101","doi-asserted-by":"crossref","unstructured":"Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK\/STAT pathway, recent advances and future challenges. Gene 2002;285:1-24.","DOI":"10.1016\/S0378-1119(02)00398-0"},{"key":"ref102","doi-asserted-by":"crossref","unstructured":"Ryder SD. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut 2003;52 Suppl 3:iii1-iii8.","DOI":"10.1136\/gut.52.suppl_3.iii1"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20933"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2011.05.001"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2005.05.006"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22506"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5852"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007122"},{"key":"ref109","unstructured":"Child CG, Turcotte JG. Surgery and portal hypertension. Major Probl Clin Surg 1964;1:1-85."},{"key":"ref110","doi-asserted-by":"crossref","unstructured":"Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-649.","DOI":"10.1002\/bjs.1800600817"},{"key":"ref111","unstructured":"Fleming I, Cooper J, Henson D, Hutter R, Kennedy BJ, Murphy G, O&rsquo;Sullivan B, Sobin L, Yarbro J. AJCC Cancer Staging Manual Philadelphia, PA: Lippincott-Raven; 1997;."},{"key":"ref112","doi-asserted-by":"crossref","unstructured":"Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, Nakajima Y, Ohnishi K. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 1985;56:918-928.","DOI":"10.1002\/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E"},{"key":"ref113","unstructured":"The general rules for the clinical and pathological study of primary liver cancer. Liver Cancer Study Group of Japan. Jpn J Surg 1989;19:98-129."}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i28\/8478.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T21:58:21Z","timestamp":1567029501000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i28\/8478.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":113,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v21.i28.8478","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}