{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:03:54Z","timestamp":1793639034770,"version":"4.5.1"},"reference-count":104,"publisher":"Baishideng Publishing Group Inc.","issue":"39","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2015]]},"DOI":"10.3748\/wjg.v21.i39.11016","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T12:24:53Z","timestamp":1445516693000},"page":"11016","source":"Crossref","is-referenced-by-count":42,"title":["Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation"],"prefix":"10.3748","volume":"21","author":[{"given":"Antonio","family":"Cuadrado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","unstructured":"Morales-Buenrostro LE, Castro R, Terasaki PI. Impact of immunosuppression on HLA-antibody formation. Clin Transpl 2006;227-240."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.03995.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318208138c"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Kamar N, Lavayssi&egrave;re L, Muscari F, Selves J, Guilbeau-Frugier C, Cardeau I, Esposito L, Cointault O, Nogier MB, Peron JM. Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation. World J Gastroenterol 2009;15:3426-3430.","DOI":"10.3748\/wjg.15.3426"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12212"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01554.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000229939.85412.27"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196904032801401"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04013.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01178.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03840.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01651105"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02519.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12589"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00500.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181902319"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31817c4cb8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.09.013"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181605cd9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03926.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.09.012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03729.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000218"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04237.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.10.048"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.02.015"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318273878c"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Smith JD, Danskine AJ, Laylor RM, Rose ML, Yacoub MH. The effect of panel reactive antibodies and the donor specific crossmatch on graft survival after heart and heart-lung transplantation. Transpl Immunol 1993;1:60-65.","DOI":"10.1016\/0966-3274(93)90060-L"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02985.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31820000a1"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.10.013"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01644.x"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Andres GA, Ansell ID, Halgrimson CG, Hsu KC, Porter KA, Starzl TE, Accinni L, Calne RY, Herbertson BM, Penn I. Immunopathological studies of orthotopic human liver allografts. Lancet 1972;1:275-280.","DOI":"10.1016\/S0140-6736(72)90288-7"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12667"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Piazza A, Adorno D, Torlone N, Valeri M, Poggi E, Monaco PI, Pisani F, Tisone G, Casciani CU. Flow cytometric analysis of antidonor-specific antibodies in liver transplant. Transplant Proc 1997;29:2975-2976.","DOI":"10.1016\/S0041-1345(97)00751-3"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Gugenheim J, Amorosa L, Gigou M, Fabiani B, Rouger P, Gane P, Reynes M, Bismuth H. Specific absorption of lymphocytotoxic alloantibodies by the liver in inbred rats. Transplantation 1990;50:309-313.","DOI":"10.1097\/00007890-199008000-00027"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03593.x"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23788"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03414.x"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22233"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Kasahara M, Kiuchi T, Takakura K, Uryuhara K, Egawa H, Asonuma K, Uemoto S, Inomata Y, Ohwada S, Morishita Y. Postoperative flow cytometry crossmatch in living donor liver transplantation: clinical significance of humoral immunity in acute rejection. Transplantation 1999;67:568-575.","DOI":"10.1097\/00007890-199902270-00014"},{"key":"ref42","unstructured":"Demetris AJ, Markus BH, Burnham J, Nalesnik M, Gordon RD, Makowka L, Starzl TE. Antibody deposition in liver allografts with chronic rejection. Transplant Proc 1987;19:121-125."},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23687"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23451"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000251361.12249.a1"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21408"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21981"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2005.03.013"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13153"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03786.x"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Demetris AJ, Nakamura K, Yagihashi A, Iwaki Y, Takaya S, Hartman GG, Murase N, Bronsther O, Manez R, Fung JJ. A clinicopathological study of human liver allograft recipients harboring preformed IgG lymphocytotoxic antibodies. Hepatology 1992;16:671-681.","DOI":"10.1002\/hep.1840160310"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800784"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Ma\u00f1ez R, Kelly RH, Kobayashi M, Takaya S, Bronsther O, Kramer D, Duquesnoy RJ, Iwaki Y, Fung JJ, Starzl TE. Immunoglobulin G lymphocytotoxic antibodies in clinical liver transplantation: studies toward further defining their significance. Hepatology 1995;21:1345-1352.","DOI":"10.1002\/hep.1840210519"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Krukemeyer MG, Moeller J, Morawietz L, Rudolph B, Neumann U, Theruvath T, Neuhaus P, Krenn V. Description of B lymphocytes and plasma cells, complement, and chemokines\/receptors in acute liver allograft rejection. Transplantation 2004;78:65-70.","DOI":"10.1097\/01.TP.0000132324.14207.8B"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Troxell ML, Higgins JP, Kambham N. Evaluation of C4d staining in liver and small intestine allografts. Arch Pathol Lab Med 2006;130:1489-1496.","DOI":"10.5858\/2006-130-1489-EOCSIL"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2009.06.004"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Matsumoto Y, McCaughan GW, Painter DM, Bishop GA. Evidence that portal tract microvascular destruction precedes bile duct loss in human liver allograft rejection. Transplantation 1993;56:69-75.","DOI":"10.1097\/00007890-199307000-00012"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23789"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23694"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23854"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Saidman SL, Duquesnoy RJ, Demetris AJ, McCauley J, Ramos H, Mazariegos G, Shapiro R, Starzl TE, Fung JJ. Combined liver-kidney transplantation and the effect of preformed lymphocytotoxic antibodies. Transpl Immunol 1994;2:61-67.","DOI":"10.1016\/0966-3274(94)90080-9"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12147"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03467.x"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Starzl TE, Demetris AJ, Todo S, Kang Y, Tzakis A, Duquesnoy R, Makowka L, Banner B, Concepcion W, Porter KA. Evidence for hyperacute rejection of human liver grafts: The case of the canary kidneys. Clin Transplant 1989;3:37-45.","DOI":"10.1111\/j.1399-0012.1989.tb00531.x"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12413"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02810.x"},{"key":"ref67","unstructured":"Ma\u00f1ez R, Bronsther O, Kusne S, Llull R, Aguado JM, Starzl TE. Vanishing bile duct syndrome after liver transplantation: alloreactivity or viral reactivity? Transplant Proc 1995;27:2280."},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711620210"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Steinhoff G, Wonigeit K, Pichlmayr R. Analysis of sequential changes in major histocompatibility complex expression in human liver grafts after transplantation. Transplantation 1988;45:394-401.","DOI":"10.1097\/00007890-198802000-00030"},{"key":"ref70","unstructured":"Gouw AS, Huitema S, Grond J, Slooff MJ, Klompmaker IJ, Gips CH, Poppema S. Early induction of MHC antigens in human liver grafts. An immunohistologic study. Am J Pathol 1988;133:82-94."},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2009.01022.x"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000638"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a44206"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22686"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21549"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Martin SR, Russo P, Dubois J, Alvarez F. Centrilobular fibrosis in long-term follow-up of pediatric liver transplant recipients. Transplantation 2002;74:828-836.","DOI":"10.1097\/00007890-200209270-00017"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20358"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23534"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000613"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007376"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23826"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01180.x"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.12.014"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2011.08.005"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23403"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.11.001"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50212"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23948"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Mauiyyedi S, Crespo M, Collins AB, Schneeberger EE, Pascual MA, Saidman SL, Tolkoff-Rubin NE, Williams WW, Delmonico FL, Cosimi AB. Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification. J Am Soc Nephrol 2002;13:779-787.","DOI":"10.1681\/ASN.V133779"},{"key":"ref90","unstructured":"Nakamura K, Yagihashi A, Iwaki Y, Takaya S, Hartman GG, Murase N, Bronsther O, Manez R, Fung JJ, Iwatsuki S. The lymphocytotoxic crossmatch in liver transplantation: a clinicopathologic analysis. Transplant Proc 1991;23:3021-3022."},{"key":"ref91","unstructured":"Ma\u00f1ez R, Kobayashi M, Takaya S, Bronsther O, Kramer D, Bonet H, Iwaki Y, Fung JJ, Demetris AJ, Starzl TE. Humoral rejection associated with antidonor lymphocytotoxic antibodies following liver transplantation. Transplant Proc 1993;25:888-890."},{"key":"ref92","unstructured":"Kobayashi M, Yagihashi A, Manez R, Takaya S, Noguchi K, Konno A, Kita Y, Yoshida Y, Terasawa K, Starzl TE. Posttransplant donor-specific T-lymphocytotoxic antibody in liver transplant patients with a positive crossmatch. Transplant Proc 1992;24:2510-2511."},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.021"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01599.x"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.08.020"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/621693"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2010.01138.x"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2011.08.015"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01309.x"},{"key":"ref100","doi-asserted-by":"crossref","unstructured":"Moreso F, Ser&oacute;n D, Carrera M, Gil-Vernet S, Cruzado JM, Hueso M, Fulladosa X, Ramos R, Ibernon M, Castelao AM. Baseline immunosuppression is associated with histological findings in early protocol biopsies. Transplantation 2004;78:1064-1068.","DOI":"10.1097\/01.TP.0000137268.85155.11"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01892.x"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2008.08.001"},{"key":"ref103","doi-asserted-by":"crossref","unstructured":"Heidt S, Roelen DL, Eijsink C, Eikmans M, van Kooten C, Claas FH, Mulder A. Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell help. Clin Exp Immunol 2010;159:199-207.","DOI":"10.1111\/j.1365-2249.2009.04051.x"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04126.x"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i39\/11016.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T23:12:47Z","timestamp":1748646767000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i39\/11016.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":104,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v21.i39.11016","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}