{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:47:41Z","timestamp":1792439261862,"version":"4.5.0"},"reference-count":88,"publisher":"Baishideng Publishing Group Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2015]]},"DOI":"10.3748\/wjg.v21.i5.1394","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T03:00:09Z","timestamp":1423191609000},"page":"1394","source":"Crossref","is-referenced-by-count":93,"title":["Management of perianal fistulas in Crohn\u2019s disease: An up-to-date review"],"prefix":"10.3748","volume":"21","author":[{"given":"Manuela","family":"Marzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.6.525"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32362"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.07.154"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2009.09.009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200102000-00014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078882"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i3.205"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34020"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.038208"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800630102"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.08.025"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199501000-00008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401804"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.01.046"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2010.09.003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(02)05909-9"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20826"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(02)00013-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28676"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200303000-00003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/BF01889235"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200412000-00014"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-003-0015-8"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/BF02052266"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03047.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318249d26c"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.3.407"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2391041043"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21934"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2333031724"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-007-9309-y"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(11)60192-8"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000436274.95722.e5"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306709"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Brandt LJ, Bernstein LH, Boley SJ, Frank MS. Metronidazole therapy for perineal Crohn’s disease: a follow-up study. Gastroenterology 1982;83:383-387.","DOI":"10.1016\/S0016-5085(82)80332-6"},{"key":"ref36","unstructured":"Jakobovits J, Schuster MM. Metronidazole therapy for Crohn’s disease and associated fistulae. Am J Gastroenterol 1984;79:533-540."},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20608"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7121"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01793.x"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02247.x"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304488"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000545.pub4"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00442.x"},{"key":"ref44","unstructured":"Hanauer SB, Smith MB. Rapid closure of Crohn’s disease fistulas with continuous intravenous cyclosporin A. Am J Gastroenterol 1993;88:646-649."},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00877-1"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01790.x"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03239.x"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.2174\/13894501113149990164"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.73"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030815"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02878.x"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.01.048"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.042"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904492"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.041"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.159251"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04466.x"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2010.07.012"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04509.x"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.07.010"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1007\/BF02052212"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4466"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0656-5"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9077-3"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6611-4"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2004.00749.x"},{"key":"ref67","unstructured":"Tanaka S, Matsuo K, Sasaki T, Nakano M, Sakai K, Beppu R, Yamashita Y, Maeda K, Aoyagi K. Clinical advantages of combined seton placement and infliximab maintenance therapy for perianal fistulizing Crohn’s disease: when and how were the seton drains removed? Hepatogastroenterology 2010;57:3-7."},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181ce8b01"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.013"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-7247-0"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02456.x"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-003-0076-8"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0288-1"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0695-y"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318239d1e4"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-009-0522-2"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Gingold DS, Murrell ZA, Fleshner PR. A prospective evaluation of the ligation of the intersphincteric tract procedure for complex anal fistula in patients with Crohn’s disease. Ann Surg 2014;260:1057-1061.","DOI":"10.1097\/SLA.0000000000000479"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0052-6"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181973487"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.214841"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1581-9"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0832-4"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21210"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31825af532"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600609941"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01561.x"},{"key":"ref87","unstructured":"Deroide G, Deroide JP. [Anal fistulae and abscesses: diagnostic and therapeutic aspects, excepting Crohn’s disease]. J Chir (Paris) 2000;137:83-92."},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-008-1487-9"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i5\/1394.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T18:29:08Z","timestamp":1598725748000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i5\/1394.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":88,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v21.i5.1394","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}