{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:04:34Z","timestamp":1784567074931,"version":"3.55.0"},"reference-count":41,"publisher":"Baishideng Publishing Group Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2015]]},"DOI":"10.3748\/wjg.v21.i5.1531","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T22:00:09Z","timestamp":1423173609000},"page":"1531","source":"Crossref","is-referenced-by-count":56,"title":["Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines"],"prefix":"10.3748","volume":"21","author":[{"given":"Dong-Hong","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04393.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24764"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2.2.233"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.021"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707449"},{"key":"ref7","unstructured":"Baroni GS, D’Ambrosio L, Curto P, Casini A, Mancini R, Jezequel AM, Benedetti A. Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology 1996;23:1189-1199."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013869"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-12-47"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1767"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1770"},{"key":"ref12","unstructured":"Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 2007;27:647-659."},{"key":"ref13","unstructured":"Radaeva S, Sun R, Pan HN, Hong F, Gao B. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 2004;39:1332-1342."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00075.2009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.03.004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25744"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2008.07.002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.05.041"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.07.031"},{"key":"ref20","unstructured":"Shi Z, Wakil AE, Rockey DC. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci USA 1997;94:10663-10668."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.08.013"},{"key":"ref22","unstructured":"Bot A. Immunoglobulin deficient mice generated by gene targeting as models for studying the immune response. Int Rev Immunol 1996;13:327-340."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01561.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9328-2"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.02.041"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22680"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i8.2062"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.05.049"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203013"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.03.025"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00085"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182449136"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.07.022"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23837"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24339"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-232"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902745106"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.02.007"},{"key":"ref39","unstructured":"Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006;24:179-189."},{"key":"ref40","unstructured":"Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007;8:967-974."},{"key":"ref41","unstructured":"Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. J Immunol 2007;179:1449-1457."}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i5\/1531.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T03:02:45Z","timestamp":1505703765000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v21\/i5\/1531.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v21.i5.1531","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}