{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:53:21Z","timestamp":1790016801860,"version":"4.0.1"},"reference-count":94,"publisher":"Baishideng Publishing Group Inc.","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2016]]},"DOI":"10.3748\/wjg.v22.i18.4427","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T06:47:40Z","timestamp":1462949260000},"page":"4427","source":"Crossref","is-referenced-by-count":48,"title":["Thrombin activation and liver inflammation in advanced hepatitis C virus infection"],"prefix":"10.3748","volume":"22","author":[{"given":"Emilio","family":"Gonz\u00e1lez-Reimers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12462"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-339-8_28"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-08-0687"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.01.069"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305996"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12221"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Bouma BN, Mosnier LO. Thrombin activatable fibrinolysis inhibitor (TAFI) at the interface between coagulation and fibrinolysis. Pathophysiol Haemost Thromb 2003;33:375-381.","DOI":"10.1159\/000083832"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230201"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(98)90096-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-014-0138-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001585"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.918"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Harada M, Fujisawa Y, Sakisaka S, Kawaguchi T, Taniguchi E, Sakamoto M, Sumie S, Sasatomi K, Koga H, Torimura T. High prevalence of anticardiolipin antibodies in hepatitis C virus infection: lack of effects on thrombocytopenia and thrombotic complications. J Gastroenterol 2000;35:272-277.","DOI":"10.1007\/s005350050345"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Ordi-Ros J, Villarreal J, Monegal F, Sauleda S, Esteban I, Vilardell M. Anticardiolipin antibodies in patients with chronic hepatitis C virus infection: characterization in relation to antiphospholipid syndrome. Clin Diagn Lab Immunol 2000;7:241-244.","DOI":"10.1128\/CDLI.7.2.241-244.2000"},{"key":"ref15","unstructured":"Violi F, Ferro D, Basili S, Artini M, Valesini G, Levrero M, Cordova C. Increased rate of thrombin generation in hepatitis C virus cirrhotic patients. Relationship to venous thrombosis. J Investig Med 1995;43:550-554."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2014.00031"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Toschi V, Fiorini GF, Motta A, Renoldi P, Paracchini ML, Gibelli A. Clinical significance of endothelial damage markers in essential mixed cryoglobulinemia. Acta Haematol 1991;86:90-94.","DOI":"10.1159\/000204810"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113351"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324441"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Falasca K, Mancino P, Ucciferri C, Dalessandro M, Zingariello P, Lattanzio FM, Petrarca C, Martinotti S, Pizzigallo E, Conti P. Inflammatory cytokines and S-100b protein in patients with hepatitis C infection and cryoglobulinemias. Clin Invest Med 2007;30:E167-E176.","DOI":"10.25011\/cim.v30i5.2892"},{"key":"ref21","unstructured":"Grignani G, Maiolo A. Cytokines and hemostasis. Haematologica 2000;85:967-972."},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Ishii H, Horie S, Kizaki K, Kazama M. Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor. Blood 1992;80:2556-2562.","DOI":"10.1182\/blood.V80.10.2556.2556"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Schleef RR, Bevilacqua MP, Sawdey M, Gimbrone MA, Loskutoff DJ. Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem 1988;263:5797-5803.","DOI":"10.1016\/S0021-9258(18)60636-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0920-1"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mn.7800198"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03674.x"},{"key":"ref27","unstructured":"Panasiuk A, Prokopowicz D, Zak J, Matowicka-Karna J, Osada J, Wysocka J. Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4. Hepatogastroenterology 2001;48:818-822."},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1086\/376971"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.02.010"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03512.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1180"},{"key":"ref32","unstructured":"Espa\u00f1ol I, Gallego A, Enr&iacute;quez J, Rabella N, Lerma E, Hern&aacute;ndez A, Pujol-Moix N. Thrombocytopenia associated with liver cirrhosis and hepatitis C viral infection: role of thrombopoietin. Hepatogastroenterology 2000;47:1404-1406."},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Adinolfi LE, Giordano MG, Andreana A, Tripodi MF, Utili R, Cesaro G, Ragone E, Durante Mangoni E, Ruggiero G. Hepatic fibrosis plays a central role in the pathogenesis of thrombocytopenia in patients with chronic viral hepatitis. Br J Haematol 2001;113:590-595.","DOI":"10.1046\/j.1365-2141.2001.02824.x"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Giannini E, Borro P, Botta F, Fumagalli A, Malfatti F, Podest&agrave; E, Romagnoli P, Testa E, Chiarbonello B, Polegato S. Serum thrombopoietin levels are linked to liver function in untreated patients with hepatitis C virus-related chronic hepatitis. J Hepatol 2002;37:572-577.","DOI":"10.1016\/S0168-8278(02)00274-X"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Goulis J, Chau TN, Jordan S, Mehta AB, Watkinson A, Rolles K, Burroughs AK. Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation. Gut 1999;44:754-758.","DOI":"10.1136\/gut.44.5.754"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Rios R, Sangro B, Herrero I, Quiroga J, Prieto J. The role of thrombopoietin in the thrombocytopenia of patients with liver cirrhosis. Am J Gastroenterol 2005;100:1311-1316.","DOI":"10.1111\/j.1572-0241.2005.41543.x"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Nagamine T, Ohtuka T, Takehara K, Arai T, Takagi H, Mori M. Thrombocytopenia associated with hepatitis C viral infection. J Hepatol 1996;24:135-140.","DOI":"10.1016\/S0168-8278(96)80021-3"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Panzer S, Seel E, Brunner M, K&ouml;rm&ouml;czi GF, Schmid M, Ferenci P, Peck-Radosavljevic M. Platelet autoantibodies are common in hepatitis C infection, irrespective of the presence of thrombocytopenia. Eur J Haematol 2006;77:513-517.","DOI":"10.1111\/j.0902-4441.2006.t01-1-EJH2888.x"},{"key":"ref39","unstructured":"Olariu M, Olariu C, Olteanu D. Thrombocytopenia in chronic hepatitis C. J Gastrointestin Liver Dis 2010;19:381-385."},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i23.7312"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011170"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0265-3"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082008000500002"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04182.x"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i19.5737"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20569"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(97)00082-7"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00096.2013"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-077909"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.026"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-014-1124-z"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.8.1206"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20166"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.3.404"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Xu Z, Westrick RJ, Shen YC, Eitzman DT. Pulmonary fibrosis is increased in mice carrying the factor V Leiden mutation following bleomycin injury. Thromb Haemost 2001;85:441-444.","DOI":"10.1055\/s-0037-1615623"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.045"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000164"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-05-0310"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06688.x"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.07.008"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50277"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1550437"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190308"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02158-14"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200210000-00049"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704039200"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Alberio L, Safa O, Clemetson KJ, Esmon CT, Dale GL. Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood 2000;95:1694-1702.","DOI":"10.1182\/blood.V95.5.1694.005k24_1694_1702"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.040"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.040"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.05.048"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21266"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240526"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196706152762403"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110709"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-8320(04)94851-8"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270221"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00285-9"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220314"},{"key":"ref79","unstructured":"Edwards RL, Levine JB, Green R, Duffy M, Mathews E, Brande W, Rickles FR. Activation of blood coagulation in Crohn&rsquo;s disease. Increased plasma fibrinopeptide A levels and enhanced generation of monocyte tissue factor activity. Gastroenterology 1987;92:329-337."},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114363"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.150748"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Kitasato L, Yamaoka-Tojo M, Hashikata T, Ishii S, Kameda R, Shimohama T, Tojo T, Ako J. Factor Xa in mouse fibroblasts may induce fibrosis more than thrombin. Int Heart J 2014;55:357-361.","DOI":"10.1536\/ihj.13-351"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210505"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210504"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-823104"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.32524"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121229"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27546"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20664"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00963.x"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i45.5007"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.07.018"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v3.i6.86"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303088"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i18\/4427.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T09:36:01Z","timestamp":1655804161000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i18\/4427.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":94,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v22.i18.4427","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}