{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:35:30Z","timestamp":1770269730232,"version":"3.49.0"},"reference-count":23,"publisher":"Baishideng Publishing Group Inc.","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2016]]},"DOI":"10.3748\/wjg.v22.i19.4662","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T05:14:54Z","timestamp":1464671694000},"page":"4662","source":"Crossref","is-referenced-by-count":13,"title":["Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung\u2019s-associated enterocolitis"],"prefix":"10.3748","volume":"22","author":[{"given":"David","family":"Coyle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin M","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Marie","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gillick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2012.07.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-006-1639-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpsurg.2004.09.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.10.052"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32835bc703"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.167676"},{"key":"ref7","unstructured":"Gershon MD. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Trans Am Clin Climatol Assoc 2012;123:268-280; discussion 280."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.105"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Galligan JJ. 5-hydroxytryptamine, ulcerative colitis, and irritable bowel syndrome: molecular connections. Gastroenterology 2004;126:1897-1899.","DOI":"10.1053\/j.gastro.2004.04.028"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Soeda J, O&rsquo;Briain DS, Puri P. Regional reduction in intestinal neuroendocrine cell populations in enterocolitis complicating Hirschsprung&rsquo;s disease. J Pediatr Surg 1993;28:1063-1068.","DOI":"10.1016\/0022-3468(93)90520-U"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Elhalaby EA, Coran AG, Blane CE, Hirschl RB, Teitelbaum DH. Enterocolitis associated with Hirschsprung&rsquo;s disease: a clinical-radiological characterization based on 168 patients. J Pediatr Surg 1995;30:76-83.","DOI":"10.1016\/0022-3468(95)90615-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1586\/egh.10.51"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6684-10.2011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14092"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12302"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024928"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01510.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.201129"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1071128"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Wedel T, Krammer HJ, K&uuml;hnel W, Sigge W. Alterations of the enteric nervous system in neonatal necrotizing enterocolitis revealed by whole-mount immunohistochemistry. Pediatr Pathol Lab Med 1998;18:57-70.","DOI":"10.1080\/107710498174227"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/scrt387"},{"key":"ref22","unstructured":"Ni She R, Filan PM. Trisomy 21--incidence and outcomes in the first year, in Ireland today. Ir Med J 2014;107:248-249."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2012.07.007"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i19\/4662.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T01:59:56Z","timestamp":1567994396000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i19\/4662.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":23,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v22.i19.4662","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}