{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:58:10Z","timestamp":1793901490928,"version":"4.8.0"},"reference-count":88,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2016]]},"DOI":"10.3748\/wjg.v22.i3.1078","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T11:57:42Z","timestamp":1452859062000},"page":"1078","source":"Crossref","is-referenced-by-count":263,"title":["Role of antibiotics for treatment of inflammatory bowel disease"],"prefix":"10.3748","volume":"22","author":[{"given":"Orna","family":"Nitzan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60751-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4137\/CGast.S12731"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0528"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2014.00019"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000435759.05577.12"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nature11053"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00505.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.22156"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v26.25877"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Sellon RK, Tonkonogy S, Schultz M, Dieleman LA, Grenther W, Balish E, Rennick DM, Sartor RB. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun 1998;66:5224-5231.","DOI":"10.1128\/IAI.66.11.5224-5231.1998"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.6.2359"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.055889"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70211-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198806000-00012"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.025403"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802433231"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.061"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Boudeau J, Glasser AL, Masseret E, Joly B, Darfeuille-Michaud A. Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn&rsquo;s disease. Infect Immun 1999;67:4499-4509.","DOI":"10.1128\/IAI.67.9.4499-4509.1999"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804812105"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066074"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.7.3380-3389.2005"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.024"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2014.07.2779"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070081"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(00)80053-3"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100015870"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i43.7577"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-014-0393-1"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.246"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.219683"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.08.001"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000024"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02163-12"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.72"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Wang SL, Wang ZR, Yang CQ. Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease. Exp Ther Med 2012;4:1051-1056.","DOI":"10.3892\/etm.2012.718"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12216"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200201000-00002"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34225"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.9.1071"},{"key":"ref43","unstructured":"Gugler R, Jensen JC, Schulte H, Vogel R. [The course of Crohn disease and side effect profile with long-term treatment using metronidazole]. Z Gastroenterol 1989;27:676-682."},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200023050-00006"},{"key":"ref45","unstructured":"Prantera C, Zannoni F, Scribano ML, Berto E, Andreoli A, Kohn A, Luzi C. An antibiotic regimen for the treatment of active Crohn&rsquo;s disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin. Am J Gastroenterol 1996;91:328-332."},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i42.4643"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.11.032"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1159\/000358141"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01842.x"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.031"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1159\/000367859"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1317-2"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32362"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02247.x"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Bernstein LH, Frank MS, Brandt LJ, Boley SJ. Healing of perineal Crohn&rsquo;s disease with metronidazole. Gastroenterology 1980;79:599.","DOI":"10.1016\/0016-5085(80)90402-3"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01589.x"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.3.331"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70476-7"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i5.1147"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.07.010"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90121-3"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i38.13999"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02516.x"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182952e93"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1185\/0300799009117003"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198708000-00011"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.10.1210"},{"key":"ref68","unstructured":"Mantzaris GJ, Archavlis E, Christoforidis P, Kourtessas D, Amberiadis P, Florakis N, Petraki K, Spiliadi C, Triantafyllou G. A prospective randomized controlled trial of oral ciprofloxacin in acute ulcerative colitis. Am J Gastroenterol 1997;92:454-456."},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1080\/00365520120413"},{"key":"ref70","unstructured":"Mantzaris GJ, Hatzis A, Kontogiannis P, Triadaphyllou G. Intravenous tobramycin and metronidazole as an adjunct to corticosteroids in acute, severe ulcerative colitis. Am J Gastroenterol 1994;89:43-46."},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.06.001"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70076-9"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1990.tb00456.x"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026648812439"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12688"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198908000-00008"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1993.tb00084.x"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21039"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"St\u00e5hlberg D, Gullberg K, Liljeqvist L, Hellers G, L&ouml;fberg R. Pouchitis following pelvic pouch operation for ulcerative colitis. Incidence, cumulative risk, and risk factors. Dis Colon Rectum 1996;39:1012-1018.","DOI":"10.1007\/BF02054692"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001176.pub2"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.01.002"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-26"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.168"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.224154"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.089953"},{"key":"ref86","unstructured":"Knutson D, Greenberg G, Cronau H. Management of Crohn&rsquo;s disease--a practical approach. Am Fam Physician 2003;68:707-714."},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.727"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.09.002"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i3\/1078.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T21:24:51Z","timestamp":1600032291000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i3\/1078.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v22.i3.1078","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}