{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T02:12:23Z","timestamp":1794103943692,"version":"4.8.0"},"reference-count":108,"publisher":"Baishideng Publishing Group Inc.","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2016]]},"DOI":"10.3748\/wjg.v22.i31.7046","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T02:36:06Z","timestamp":1471228566000},"page":"7046","source":"Crossref","is-referenced-by-count":35,"title":["Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer"],"prefix":"10.3748","volume":"22","author":[{"given":"Chi-Hin","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","reference":[{"key":"ref1","unstructured":"American Cancer Society, Cancer Facts and Figures 2015 Atlanta: American Cancer Society; 2015;."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-005-0539-4"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Burris HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-2413.","DOI":"10.1200\/JCO.1997.15.6.2403"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt066"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Slack JM. Developmental biology of the pancreas. Development 1995;121:1569-1580.","DOI":"10.1242\/dev.121.6.1569"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016786"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.441"},{"key":"ref10","unstructured":"Rozenblum E, Schutte M, Goggins M, Hahn SA, Panzer S, Zahurak M, Goodman SN, Sohn TA, Hruban RH, Yeo CJ. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 1997;57:1731-1734."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Friess H, Berberat P, Schilling M, Kunz J, Korc M, Büchler MW. Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors. J Mol Med (Berl) 1996;74:35-42.","DOI":"10.1007\/BF00202070"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164368"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061176"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15889"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01925"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.11.052"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.01.012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305203282001"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Seger R, Krebs EG. The MAPK signaling cascade. FASEB J 1995;9:726-735.","DOI":"10.1096\/fasebj.9.9.7601337"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nri2818"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.389"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2735"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.10.011"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110530"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5272498"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.033"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601246"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/32100"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/356801a0"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609217104"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.10.025"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300266"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1101\/gad.204453.112"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7200"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705953104"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-7-4"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvv124"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.11.060"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.4161\/org.4.2.5849"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.4161\/org.4.2.5851"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40045"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.11.003"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4384"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.089"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)01444-3"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040031"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3359"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051468"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010048"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2015.5"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.10.007"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1038\/23716"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00140-5"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.5.5531"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15051"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200105060"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1242\/dev.000786"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.7.2673-2681.2004"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.066"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200304159"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.01.023"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1101\/gad.249409.114"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.032"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.535"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2476"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.066"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908428107"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.06.046"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2004.06.007"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303328"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308042"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.23.3752"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01280"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.1.117-130.2006"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304287"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1242\/dev.109405"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07125"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-011-1620-1"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-1899-6"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2003.10.028"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2011.1180"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Göke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Göke B. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J Biol Chem 1993;268:19650-19655.","DOI":"10.1016\/S0021-9258(19)36565-2"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1169"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.017608"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1038\/nature756"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.3109\/08977191003738832"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102559"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.21.15115"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm267"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-8-52"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1952"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2251"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0053"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087900"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00838-1"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12675"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12501"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.210"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000328"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25668"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002841"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23307"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1042\/CBI20120210"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0502"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000373"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.032003"},{"key":"ref108","unstructured":"El-Metwally TH, Pour PM. The retinoid induced pancreatic cancer redifferentiation-apoptosis sequence and the mitochondria: a suggested obligatory sequence of events. JOP 2007;8:268-278."}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i31\/7046.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T23:37:00Z","timestamp":1657064220000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i31\/7046.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":108,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v22.i31.7046","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}